{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:12:48Z","timestamp":1787008368692,"version":"build-2736575974"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Outstanding Youth Talents (2021) of Wuhan, and PhD foundation of Wuhan Children\u2019s Hospital","award":["2024FEBSJJ001"],"award-info":[{"award-number":["2024FEBSJJ001"]}]},{"name":"Knowledge Innovation project of Wuhan Science and Technology Bureau","award":["2023020201020553"],"award-info":[{"award-number":["2023020201020553"]}]},{"name":"Hubei Provincial Natural Science Foundation of China","award":["2023AFB364"],"award-info":[{"award-number":["2023AFB364"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304100"],"award-info":[{"award-number":["82304100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Emerging evidence links per- and polyfluoroalkyl substances (PFAS) exposure and metabolic disruptions to fetal growth retardation. However, earlier studies on singletons could not fully account for genetic factors. Therefore, we used a cotwin control study design to identify cord metabolomic signatures of PFAS exposure and assess its mediating role in twin birthweight discordance. We analyzed 204 twin neonates born from the Wuhan Twin Birth Cohort (August 2016 to January 2018). Cord serum PFAS concentrations and untargeted metabolomic profiles were determined using liquid chromatography-tandem mass spectrometry. Within-twin metabolome-wide association analyses identified 69 metabolites (effect coefficients: 0.09-0.35) positively associated with log2-transformed perfluorooctanoic acid difference and 51 metabolites (effect coefficients: 0.08-0.38) positively associated with log2-transformed perfluoroheptane sulfonate (PFHpS) difference after false discovery rate correction. PFAS-associated metabolites were primarily enriched in steroid hormone biosynthesis, arginine and proline metabolism, glycerophospholipid metabolism, and unsaturated fatty acid biosynthesis pathways. Five amino acids, one carbohydrate, one cofactor and vitamin, and five lipids mediated the relationship between PFHpS exposure difference and intratwin birthweight difference, with mediation proportions ranging from 32.0% to 72.7%. This study is the first to use a within-twin comparison, providing new insights into the underlying mechanisms linking PFAS exposure with twin birthweight discordance.<\/jats:p>","DOI":"10.1093\/aje\/kwaf033","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T08:49:15Z","timestamp":1740473355000},"page":"70-80","source":"Crossref","is-referenced-by-count":5,"title":["Cord serum metabolomic profiling associated with in utero exposure to per- and polyfluoroalkyl substances and birthweight discordance in twins: findings from Wuhan Twin Birth Cohort"],"prefix":"10.1093","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1284-7271","authenticated-orcid":false,"given":"Liqin","family":"Hu","sequence":"first","affiliation":[{"name":"Institute of Maternal and Child Health, Wuhan Children\u2019s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology , Wuhan ,","place":["PR 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