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In this commentary, we discuss the use and value of AL as a measure to assess exposure to stress for cancer epidemiologic studies, describe the existing evidence between AL and sources of cancer-related environmental stressors, and summarize the existing epidemiologic studies on AL and cancer risk, progression, and mortality. We also outline several knowledge gaps and what steps should be considered to advance research on the role of AL and cancer risk, progression, and mortality in human populations.<\/jats:p>","DOI":"10.1093\/aje\/kwaf038","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T07:36:21Z","timestamp":1740641781000},"page":"1485-1495","source":"Crossref","is-referenced-by-count":11,"title":["Allostatic load and cancer risk, progression, and mortality in epidemiologic studies"],"prefix":"10.1093","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6651-9719","authenticated-orcid":false,"given":"Naoko","family":"Ishibe","sequence":"first","affiliation":[{"name":"Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health , Department of Health and Human Services, 9609 Medical Center Drive, Bethesda, MD, 20892 ,","place":["United 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