{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:49:14Z","timestamp":1789148954996,"version":"build-2803163510"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Scientific Research Program of FuRong Laboratory, China","award":["2024PT5108"],"award-info":[{"award-number":["2024PT5108"]}]},{"name":"Scientific Research Program of FuRong Laboratory, China","award":["2023SK2100"],"award-info":[{"award-number":["2023SK2100"]}]},{"name":"National Key Research and Development Plan of China","award":["2022YFC3601900"],"award-info":[{"award-number":["2022YFC3601900"]}]},{"name":"National Key Research and Development Plan of China","award":["2022YFC2505500"],"award-info":[{"award-number":["2022YFC2505500"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Previous studies have reported that walking is associated with a lower risk of several metabolic diseases; however, evidence of its association with gout, a metabolic condition, is lacking. We conducted cohort studies using data from the UK Biobank (2013-2021) to examine the relationship of walking volume and intensity with the risk of incident gout. We included 92\u2009066 participants who were free of gout and had valid baseline seven-day accelerometer data, which allowed us to derive walking volume (total steps), walking intensity (peak 30-minute cadence), and their combination (purposeful steps). Hazard ratios (HRs) for incident gout were estimated across different walking activity metrics groups using Cox proportional hazard models. During a mean follow-up period of 6.93\u00a0years, 706 participants developed incident gout. Walking volume and intensity alone showed no significant relationship to the risk of incident gout. However, compared with the low group (&amp;lt;5000 steps\/day) of purposeful steps, the risk of incident gout was lower in the middle group (5000\u20137999 steps\/day) and high (\u22658000 steps\/day) group, with adjusted HRs and 95% confidence intervals of 0.78 (0.66\u20130.94) and 0.72 (0.58\u20130.90), respectively (P for trend = 0.003). These findings offer valuable insights into developing walking-based recommendations to prevent incident gout.<\/jats:p>","DOI":"10.1093\/aje\/kwaf109","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T08:05:03Z","timestamp":1747987503000},"page":"2945-2953","source":"Crossref","is-referenced-by-count":2,"title":["Association of walking volume and intensity with incident gout: a population-based cohort study"],"prefix":"10.1093","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5127-5253","authenticated-orcid":false,"given":"Ziying","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Xiangya Hospital Central South University , Changsha, Hunan, 410008 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3635-3444","authenticated-orcid":false,"given":"Ying","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of 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Mongan Institute, Massachusetts General Hospital, Harvard Medical School , Boston, MA 02114 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-4476","authenticated-orcid":false,"given":"Nicola","family":"Dalbeth","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Auckland , Auckland, Auckland, 1010 ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0040-0042","authenticated-orcid":false,"given":"Junqing","family":"Xie","sequence":"additional","affiliation":[{"name":"Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford , Oxford, England, OX3 7LD ,","place":["United 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,","place":["China"]},{"name":"Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University , Changsha, Hunan, 410008 ,","place":["China"]},{"name":"Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Central South University , Changsha, Hunan, 410008 ,","place":["China"]},{"name":"Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital Central South University , Changsha, Hunan, 410008 ,","place":["China"]},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha, Hunan, 410008 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2987-138X","authenticated-orcid":false,"given":"Guanghua","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Xiangya Hospital Central South University , Changsha, Hunan, 410008 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