{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:16:05Z","timestamp":1775805365042,"version":"3.50.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Testicular cancer is the most common malignancy in males aged 15 to 34\u00a0years, yet the value of screening asymptomatic adolescents remains unclear. We conducted a nationwide, population-based cohort study of 300\u2009793 Israeli males aged 16 to 21\u00a0years who underwent clinical testicular examinations between 2012 and 2021 before mandatory military service, generally lasting 3\u00a0years. Participants were followed for incident testicular cancer during their service. Screening involved inspection and palpation by general physicians, with referrals to ultrasound and urologists for suspicious findings. During 1\u2009172\u2009603 person-years of follow-up, 43 cases of testicular cancer were identified (incidence rate, 3.67 per 100\u2009000 person-years). The sensitivity of screening was 66.7% and 40% at 6 and 12\u00a0months, respectively. Each cancer detected required screening 75\u2009198 adolescents and included 176 ultrasound tests and 112 specialist consultations. Most cancers were diagnosed at stage I regardless of screening. The low sensitivity, high number needed to screen, frequent unnecessary evaluations, and low incidence of testicular cancer suggest that routine screening of asymptomatic adolescents is ineffective. These findings do not support routine testicular cancer screening in this population.<\/jats:p>","DOI":"10.1093\/aje\/kwaf241","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:07:09Z","timestamp":1761916029000},"page":"1009-1014","source":"Crossref","is-referenced-by-count":0,"title":["Screening of adolescents for testicular cancer-a nationwide retrospective cohort study"],"prefix":"10.1093","volume":"195","author":[{"given":"Yair","family":"Zloof","sequence":"first","affiliation":[{"name":"Medical Corps, Israel Defense Forces , Ramat Gan ,","place":["Israel"]},{"name":"Department of Preventive Medicine and Epidemiology, School of Public Health, Gray Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv ,","place":["Israel"]},{"name":"Schneider Children\u2019s Medical Center of Israel , Petach Tikva 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The Hebrew University of Jerusalem , Jerusalem ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dotan","family":"Yaari","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sheba Medical Center , Tel Hashomer ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel S","family":"Sirat","sequence":"additional","affiliation":[{"name":"Medical Corps, Israel Defense Forces , Ramat Gan ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidor","family":"Peretz","sequence":"additional","affiliation":[{"name":"Medical Corps, Israel Defense Forces , Ramat Gan ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9368-3490","authenticated-orcid":false,"given":"Arik","family":"Eisenkraft","sequence":"additional","affiliation":[{"name":"The Institute for Research in Military Medicine, The Hebrew University 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