{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:23:22Z","timestamp":1783513402301,"version":"3.55.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1000307"],"award-info":[{"award-number":["2016YFC1000307"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project of National Research Institute for Family Planning of China","award":["2018NRIFPJ03"],"award-info":[{"award-number":["2018NRIFPJ03"]}]},{"name":"Basic Research Funds of Central Public Welfare Research Institutes of China","award":["2023GJZ03"],"award-info":[{"award-number":["2023GJZ03"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62027827"],"award-info":[{"award-number":["62027827"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The birth and diagnosis of a child with congenital abnormalities can alter parental reproductive patterns, yet its association with subsequent fecundability remains insufficiently explored. We conducted a government-supported matched cohort study in China to evaluate this association and assess whether it varies by the severity of the child\u2019s condition and parental characteristics. A total of 2448 couples from the National Free Preconception Check-up Project between 2012 and 2018 attempting to conceive again were included: 612 exposed couples with children affected by congenital abnormalities and 1836 nonexposed couples with unaffected children and no adverse pregnancy history. Participants were followed via telephone every 3\u00a0months for 1 year to track pregnancy outcomes. Cox proportional hazards models with a shared frailty were used to estimate HRs and 95% CIs for fecundability. Overall, exposed couples demonstrated a 28% higher fecundability than nonexposed couples (HR 1.28 [95% CI, 1.10-1.49]). This association was primarily observed among parents with \u201chealthy\u201d characteristics and those whose children had single-system\/body part congenital abnormalities (HR 1.27 [95% CI, 1.09-1.48]). These findings highlight the importance of integrated fertility counseling, prenatal screening, and psychological support for families seeking subsequent pregnancies after the birth of a child with congenital abnormalities.<\/jats:p>","DOI":"10.1093\/aje\/kwaf267","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T12:38:11Z","timestamp":1765197491000},"page":"1866-1875","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of subsequent fecundability in parents of children with congenital abnormalities: a matched cohort study from China"],"prefix":"10.1093","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7658-3842","authenticated-orcid":false,"given":"Jun","family":"Zhao","sequence":"first","affiliation":[{"name":"Human Genetic Resources Center, National Research Institute for Family Planning , Beijing ,","place":["China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6880-2495","authenticated-orcid":false,"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Human Genetic Resources Center, National Research Institute for Family Planning , Beijing ,","place":["China"]},{"name":"Department of Maternal and Child Health, School of Public Health, Peking University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongguang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Human Genetic Resources Center, National Research Institute for Family Planning , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoqi","family":"Peng","sequence":"additional","affiliation":[{"name":"Human Genetic Resources Center, National Research Institute for Family Planning , Beijing 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,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1260-1038","authenticated-orcid":false,"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Human Genetic Resources Center, National Research Institute for Family Planning , Beijing ,","place":["China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health, Henan Academy of Innovations in Medical Science , Zhengzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2019e","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Science and Technology Service, Hubei Health Science and Technology Service Center , Wuhan 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