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Based on data from China Kadoorie Biobank (10\u2009298 patients aged 30-79\u00a0years) and UK Biobank (4975 patients aged 37-73\u00a0years), composite SDoH scores incorporating 5 domains (financial circumstances, education, healthcare access, neighborhood environment, and social context) were generated based on mortality associations and categorized into favorable, medium, and unfavorable groups. During a median follow-up of 10.4\u00a0years (China) and 13.8\u00a0years (UK), unfavorable SDoH was associated with higher mortality risk in both cohorts (China: HR, 1.62 [95% CI, 1.36-1.92]; UK: HR, 1.80 [95% CI, 1.50-2.16]). Life expectancy reduction at age 45 due to unfavorable SDoH showed sex-specific patterns within each cohort: in China, women lost 4.7\u00a0years and men lost 4\u00a0years; in the UK, men lost 6.8\u00a0years and women lost 4\u00a0years. Phenome-wide analysis for incident diseases identified 51 conditions with 1.2- to 5.2-fold increased risks among those with unfavorable SDoH, including heart failure, obstructive chronic bronchitis, and renal failure. Findings suggest that disadvantaged SDoHs were associated with significantly lower life expectancy and higher risks of multiple adverse health outcomes among adults with RA.<\/jats:p>","DOI":"10.1093\/aje\/kwag039","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:41:20Z","timestamp":1772109680000},"page":"1922-1932","source":"Crossref","is-referenced-by-count":0,"title":["Social determinants of health, life expectancy, and future health risks among adults with rheumatoid arthritis: two cohort studies in China and the UK"],"prefix":"10.1093","volume":"195","author":[{"given":"Jie","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Public Health, Anhui University of Science and Technology , Hefei, Anhui, 231131 ,","place":["China"]},{"name":"Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine , New Orleans, LA 70112 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Anhui Medical University , Hefei, Anhui 231131 ,","place":["China"]},{"name":"Inflammation and Immune Mediated Diseases Laboratory of Anhui Province , Hefei, Anhui 230032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianling","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Fudan University , Shanghai 200030 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Huang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai 200031 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoriko","family":"Heianza","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine , New Orleans, LA 70112 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Ma","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai 200031 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8041-7791","authenticated-orcid":false,"given":"Lu","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine , New Orleans, LA 70112 ,","place":["United States"]},{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health , Boston, MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6604-9614","authenticated-orcid":false,"given":"Dongqing","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Public Health, Anhui University of Science and Technology , Hefei, Anhui, 231131 ,","place":["China"]},{"name":"Department of Epidemiology, School of Public Health, Anhui Medical University , Hefei, Anhui 231131 ,","place":["China"]},{"name":"Inflammation and Immune Mediated Diseases Laboratory of Anhui Province , Hefei, Anhui 230032 ,","place":["China"]},{"name":"Joint Research Center of Occupational Medicine and Health, Institute of Grand Health , Hefei Comprehensive National Science Center, Hefei, Anhui 231131 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