{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:16:28Z","timestamp":1780499788304,"version":"3.54.1"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"6","funder":[{"name":"the US Army Medical Research Acquisition Activity through the Peer Review Cancer Research Program Discovery Award","award":["W81XWH-12-1-0369"],"award-info":[{"award-number":["W81XWH-12-1-0369"]}]},{"DOI":"10.13039\/100000016","name":"Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"US National Cancer Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Intramural Research Program of the Division of Cancer Epidemiology and Genetics"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The ABO locus is associated with pancreatic ductal adenocarcinoma (PDAC). Potential metabolic mechanisms underlying these associations have not been investigated. We examined associations between genotype-derived ABO blood group (rs505922 and rs8176746) and 1478 prediagnostic serum metabolites in 4042 participants from 8 nested case\u2013control studies within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial and Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study using linear regression and fixed-effect meta-analysis. We then examined associations between the identified ABO-associated metabolites and PDAC in 2 nested case\u2013control studies (493 cases, 640 controls) using logistic regression and evaluated metabolite mediation of the ABO-PDAC association. Non-O and A (vs O) blood groups were associated with 13 and 20 metabolites, respectively, at false discovery rate\u00a0&amp;lt;0.20, with 9 in common. The ABO-associated metabolites, sphingosine (non-O: \u03b2\u00a0=\u00a00.15), aspartate (A: \u03b2\u00a0=\u00a0\u20130.11), and aspartylphenylalanine (A: \u03b2\u00a0=\u00a0\u20130.16) were positively, and fibrinopeptide B (1-13) (non-O: \u03b2\u00a0=\u00a00.13; A: \u03b2\u00a0=\u00a00.21) was inversely associated with PDAC (OR\u00a0=\u00a00.96-1.07 per SD change log10-metabolite, P\u00a0&amp;lt;.05) after adjustment for blood group. Non-O (OR\u00a0=\u00a01.50 [95% CI,\u00a01.16-1.94]) and A (OR\u00a0=\u00a01.46 [95% CI,\u00a01.10-1.92]) (vs O) blood groups were associated with PDAC, however none of the ABO associated metabolites significantly mediated the association between ABO blood group and PDAC. Our results suggest the ABO-associated metabolites are independent risk factors for PDAC.<\/jats:p>\n                  <jats:p>Trial registration: NCT00342992 and NCT00339495.<\/jats:p>","DOI":"10.1093\/aje\/kwag055","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T09:56:54Z","timestamp":1773136614000},"page":"1572-1584","source":"Crossref","is-referenced-by-count":0,"title":["Metabolomic profiling of genotype-derived ABO blood group, secretor status, and Lewis antigens and association with pancreatic ductal adenocarcinoma risk"],"prefix":"10.1093","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9862-9434","authenticated-orcid":false,"given":"Ting","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, MD ,","place":["United 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of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, MD ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3573-8748","authenticated-orcid":false,"given":"Erikka","family":"Loftfield","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, MD ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary C","family":"Playdon","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Integrative Physiology, University of Utah , Salt Lake City, UT ,","place":["United States"]},{"name":"Cancer Control and Population Sciences Program, Huntsman Cancer Institute, University of Utah , Salt Lake City, UT ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, MD ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5337-137X","authenticated-orcid":false,"given":"Kai","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, MD ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3698-7006","authenticated-orcid":false,"given":"Rachael Z","family":"Stolzenberg-Solomon","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, MD ,","place":["United 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