{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:23:37Z","timestamp":1790011417423,"version":"4.0.1"},"reference-count":75,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The potential for trace amounts of selenium supplements to prevent prostate cancer and other neoplasms was studied in the Selenium and Vitamin E Prevention Trial, a randomized trial conducted in North America for 7-12\u00a0years. A total of 34\u2009887 eligible men aged 55 or older were assigned to take either 200\u00a0\u03bcg selenium from L-selenomethionine, 400\u00a0IU vitamin E, both selenium and vitamin E, or placebo. The trial was stopped for futility and concerns about adverse effects. Subsequently, we used incidence and mortality data from Medicare through 2019 and the National Death Index through 2024 to investigate the extent to which selenium administration was associated with increased long-term risk of cancer and neurodegenerative disease, during 341\u2009697 person-years of follow-up. Lung cancer showed little increased risk. Associations were near null for leukemia, non\u2013Hodgkin lymphoma, and Parkinson\u2019s disease, and there was a lower risk for melanoma and colorectal cancer. In contrast, we found a higher risk for Hodgkin lymphoma, multiple myeloma, and amyotrophic lateral sclerosis, which has been associated with selenium overexposure in some nonexperimental studies. Though these latter associations were based on few cases, they were consistent with findings from a range of other studies, possibly indicating long\u2013term adverse effects of this organic selenium compound (registration no. NCT00006392).<\/jats:p>","DOI":"10.1093\/aje\/kwag189","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:53:35Z","timestamp":1785930815000},"source":"Crossref","is-referenced-by-count":1,"title":["The Selenium and Vitamin E Cancer Prevention Trial (SELECT): a secondary, post-intervention analysis on potential excess chronic disease incidence induced by selenium administration"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0551-2473","authenticated-orcid":false,"given":"Marco","family":"Vinceti","sequence":"first","affiliation":[{"name":"Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia , Modena ,","place":["Italy"]},{"name":"Department of Epidemiology, Boston University School of Public Health , Boston, MA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6801-8333","authenticated-orcid":false,"given":"Cathee","family":"Till","sequence":"additional","affiliation":[{"name":"SWOG Statistics and Data Management Center, Fred Hutchinson Cancer , Seattle, WA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9660-7074","authenticated-orcid":false,"given":"Phyllis J","family":"Goodman","sequence":"additional","affiliation":[{"name":"SWOG Statistics and Data Management Center, Fred Hutchinson Cancer , Seattle, WA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2100-0344","authenticated-orcid":false,"given":"Tommaso","family":"Filippini","sequence":"additional","affiliation":[{"name":"Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia , Modena ,","place":["Italy"]},{"name":"School of Public Health, University of California Berkeley , Berkeley, CA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J","family":"Rothman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Boston University School of Public Health , Boston, MA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M","family":"Thompson Jr.","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at San Antonio , San Antonio, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"issue":"2","key":"2026082720062087600_ref1","doi-asserted-by":"publisher","first-page":"CD005195","DOI":"10.1002\/14651858.CD005195.pub4","article-title":"Selenium for preventing cancer","volume":"2020","author":"Vinceti","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"2026082720062087600_ref2","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1080\/10590501.2013.844757","article-title":"Friend or foe? 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