{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:57:50Z","timestamp":1791223070519,"version":"4.1.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"NHLBI, NIH, and DHHS","award":["75N92022D00001-5"],"award-info":[{"award-number":["75N92022D00001-5"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01HL158022"],"award-info":[{"award-number":["R01HL158022"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Type 2 diabetes is a risk factor for cardiac arrhythmias, but it is unknown how specific aberrations in glucose (eg, episodes of high or low glucose) might contribute to the occurrence of heart rhythm abnormalities. The overarching goal of this study is to address research questions regarding how glucose patterns might contribute to the occurrence of arrhythmias, primarily atrial fibrillation, in adults with diabetes. To fulfill this goal, the Atherosclerosis Risk in Communities Generation 2 (ARIC Gen2) study recruited 507 community-dwelling adults aged 50-80\u00a0years with type 2 diabetes to wear continuous glucose monitoring (CGM) and electrocardiogram (ECG) \u201cpatch\u201d monitoring sensors simultaneously for up to 14\u00a0days. Generation 2 study had high CGM and ECG completeness: The median wear time for sensors was 14\u00a0days and ~80% of participants wore both sensors for \u226510\u00a0days. By combining Gen2 and data from the original ongoing ARIC cohort (aged 80+), we have the capacity to conduct a comprehensive evaluation of the impact of CGM-defined glucose patterns on arrhythmias across a wide age spectrum from middle-aged to very old adults (aged 50-100) with type 2 diabetes. The findings from this study may help inform clinical strategies for the prevention and management of arrhythmias among adults with type 2 diabetes.<\/jats:p>","DOI":"10.1093\/aje\/kwag237","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:26:05Z","timestamp":1789755965000},"source":"Crossref","is-referenced-by-count":0,"title":["Rationale and design of the Atherosclerosis Risk in Communities Generation 2 study"],"prefix":"10.1093","author":[{"given":"Dan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21287 ,","place":["United States"]},{"name":"Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University , Baltimore, MD 21287 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie R","family":"Daya","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21287 ,","place":["United States"]},{"name":"Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University , Baltimore, MD 21287 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5607-4848","authenticated-orcid":false,"given":"Mary R","family":"Rooney","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21287 ,","place":["United States"]},{"name":"Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University , Baltimore, MD 21287 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arielle","family":"Valint","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Minotti","sequence":"additional","affiliation":[{"name":"George W. Comstock Center for Public Health Research and Prevention, Johns Hopkins Bloomberg School of Public Health , Hagerstown, MD 21740 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21287 ,","place":["United States"]},{"name":"Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University , Baltimore, MD 21287 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University , Baltimore, MD 21287 ,","place":["United States"]},{"name":"Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine , Baltimore, MD 21224 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne E","family":"Wagenknecht","sequence":"additional","affiliation":[{"name":"Public Health Sciences, Wake Forest University School of Medicine , Winston-Salem, NC 27106 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly Gwen","family":"Windham","sequence":"additional","affiliation":[{"name":"Memory Impairment and Neurodegenerative Dementia (MIND) Center, Department of Medicine, Division of Geriatric Medicine, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1572-1340","authenticated-orcid":false,"given":"Pamela L","family":"Lutsey","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health, University of Minnesota , Minneapolis, MN 55454 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4313-9235","authenticated-orcid":false,"given":"David","family":"Couper","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4598-0669","authenticated-orcid":false,"given":"Josef","family":"Coresh","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins University , Baltimore, MD 21218 ,","place":["United States"]},{"name":"Optimal Aging Institute, New York University Grossman School of Medicine , New York, NY 10016 ,","place":["United States"]},{"name":"Departments of Population Health and Medicine, New York University Grossman School of Medicine , New York, NY 10016 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin B","family":"Echouffo-Tcheugui","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine , Baltimore, MD 21224 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin Yee","family":"Chen","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, University of Minnesota Medical School , Minneapolis, MN 55455 ,","place":["United States"]},{"name":"Lillehei Heart Institute, University of Minnesota Medical School , Minneapolis, MN 55455 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6923-7151","authenticated-orcid":false,"given":"Elizabeth","family":"Selvin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21287 ,","place":["United States"]},{"name":"Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University , Baltimore, MD 21287 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"issue":"Suppl 1","key":"2026100513373481300_ref1","doi-asserted-by":"publisher","first-page":"S179","DOI":"10.2337\/dc24-S010","article-title":"10. 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