{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:49:33Z","timestamp":1792612173515,"version":"4.5.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["Grant No. 2016YFC1000307"],"award-info":[{"award-number":["Grant No. 2016YFC1000307"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project of National Research Institute for Family Planning of China","award":["Grant No. 2018NRIFPJ03"],"award-info":[{"award-number":["Grant No. 2018NRIFPJ03"]}]},{"name":"Basic Research Funds of Central Public Welfare Research Institutes of China","award":["grant 2023GJZ03"],"award-info":[{"award-number":["grant 2023GJZ03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Among couples with non-smoking wives, the relationship between husband smoking and fecundability remains uncertain. Evidence is limited regarding whether smoking cessation before conception is associated with improved fecundability. We included a total of 4,569,530 reproductive-aged couples with non-smoking wives from the National Free Pre-conception Check-up Project in China from 2015 to 2017. Cox proportional hazards models were used to estimate fecundability hazard ratios (HRs) and 95% confidence intervals (CIs). Among 4,569,530 eligible couples, 1,228,222 (26.88%) husbands reported smoking at baseline. Within 1 year, 3,046,804 couples (66.68%) conceived, with a median TTP of 2.76 cycles. Husband smoking was associated with lower fecundability (HR=0.97, 95% CI, 0.97-0.97), demonstrating a dose-response relationship. Among 781,481 couples in which the husband smoked and conception occurred within 1 year, 507,530 (64.94%) reported smoking cessation. Smoking cessation was associated with higher fecundability (HR=1.23, 95% CI, 1.23-1.24), with consistent benefits across prior smoking levels, although the magnitude of improvement was smaller among husbands who smoked more heavily. Associations varied by age and were more pronounced in older couples. These findings support the inclusion of husband smoking cessation in preconception care and highlight its potential role in promoting smoke-free households and broader tobacco control efforts.<\/jats:p>","DOI":"10.1093\/aje\/kwag247","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:43:17Z","timestamp":1792496597000},"source":"Crossref","is-referenced-by-count":0,"title":["Husband smoking, smoking cessation, and fecundability among couples with non-smoking wives"],"prefix":"10.1093","author":[{"given":"Yue","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Maternal and Child Health, School of Public Health, Peking University , Beijing ,","place":["China"]},{"name":"National Research Institute for Family Planning , Beijing ,","place":["China"]},{"name":"National Human Genetic Resources Center , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongguang","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Research Institute for Family Planning , Beijing ,","place":["China"]},{"name":"National Human Genetic Resources Center , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, School of Public Health, Peking University , Beijing ,","place":["China"]},{"name":"National Health Commission Key Laboratory of Reproductive Health, School of Public Health, Peking University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7658-3842","authenticated-orcid":false,"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[{"name":"National Research Institute for Family Planning , Beijing ,","place":["China"]},{"name":"National Human Genetic Resources Center , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailei","family":"Jiao","sequence":"additional","affiliation":[{"name":"National Research Institute for Family Planning , Beijing ,","place":["China"]},{"name":"National Human Genetic Resources Center , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Research Institute for Family Planning , Beijing ,","place":["China"]},{"name":"National Human Genetic Resources Center , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1003-619X","authenticated-orcid":false,"given":"Jingwei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Barnett College of Public Health, Temple University , Philadelphia, PA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"National Research Institute for Family Planning , Beijing ,","place":["China"]},{"name":"National Human Genetic Resources Center , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoqi","family":"Peng","sequence":"additional","affiliation":[{"name":"National Research Institute for Family Planning , Beijing ,","place":["China"]},{"name":"National Human Genetic Resources Center , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Research Institute for Family Planning , Beijing ,","place":["China"]},{"name":"National Human Genetic Resources Center , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueshu","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Zhengzhou University , Henan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaomei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, National Health Commission of the People's Republic of China , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, National Health Commission of the People's Republic of China , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, National Health Commission of the People's Republic of China , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghai","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, National Health Commission of the People's Republic of China , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5358-2946","authenticated-orcid":false,"given":"Xu","family":"Ma","sequence":"additional","affiliation":[{"name":"National Research Institute for Family Planning , Beijing ,","place":["China"]},{"name":"National Human Genetic Resources Center , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,21]]},"container-title":["American Journal of Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/aje\/advance-article-pdf\/doi\/10.1093\/aje\/kwag247\/72258151\/kwag247.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/aje\/advance-article-pdf\/doi\/10.1093\/aje\/kwag247\/72258151\/kwag247.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:28:04Z","timestamp":1792610884000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/aje\/advance-article\/doi\/10.1093\/aje\/kwag247\/8965295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/aje\/kwag247","relation":{},"ISSN":["0002-9262","1476-6256"],"issn-type":[{"value":"0002-9262","type":"print"},{"value":"1476-6256","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,21]]},"article-number":"kwag247"}}