{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T20:42:22Z","timestamp":1783802542518,"version":"3.55.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,11,15]]},"DOI":"10.1093\/aje\/kwi317","type":"journal-article","created":{"date-parts":[[2005,10,5]],"date-time":"2005-10-05T20:25:34Z","timestamp":1128543934000},"page":"983-990","source":"Crossref","is-referenced-by-count":123,"title":["Coffee and Fetal Death: A Cohort Study with Prospective Data"],"prefix":"10.1093","volume":"162","author":[{"given":"Bodil Hammer","family":"Bech","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen Aagaard","family":"Nohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Vaeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine Brink","family":"Henriksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rn","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,10,5]]},"reference":[{"key":"key\n\t\t\t\t20171010161849_BIB1","unstructured":"Danish Coffee Information. The ten most coffee drinking nations, 2005. (In Danish). Copenhagen, Denmark: Danish Coffee Information, 2005. (http:\/\/www.kaffeinfo.dk\/tal\/05_top10.html)."},{"key":"key\n\t\t\t\t20171010161849_BIB2","doi-asserted-by":"crossref","unstructured":"Cnattingius S, Signorello LB, Anneren G, et al. Caffeine intake and the risk of first-trimester spontaneous abortion. N Engl J Med2000;343:1839\u201345.","DOI":"10.1056\/NEJM200012213432503"},{"key":"key\n\t\t\t\t20171010161849_BIB3","doi-asserted-by":"crossref","unstructured":"Furuhashi N, Sato S, Suzuki M, et al. Effects of caffeine ingestion during pregnancy. Gynecol Obstet Invest1985;19:187\u201391.","DOI":"10.1159\/000299032"},{"key":"key\n\t\t\t\t20171010161849_BIB4","doi-asserted-by":"crossref","unstructured":"Vlajinac HD, Petrovic RR, Marinkovic JM, et al. Effect of caffeine intake during pregnancy on birth weight. Am J Epidemiol1997;145:335\u20138.","DOI":"10.1093\/oxfordjournals.aje.a009110"},{"key":"key\n\t\t\t\t20171010161849_BIB5","doi-asserted-by":"crossref","unstructured":"Fortier I, Marcoux S, Beaulac-Baillargeon L. Relation of caffeine intake during pregnancy to intrauterine growth retardation and preterm birth. Am J Epidemiol1993;137:931\u201340.","DOI":"10.1093\/oxfordjournals.aje.a116763"},{"key":"key\n\t\t\t\t20171010161849_BIB6","doi-asserted-by":"crossref","unstructured":"Goldstein A, Warren R. Passage of caffeine into human gonadal and fetal tissue. Biochem Pharmacol1962;11:166\u20138.","DOI":"10.1016\/0006-2952(62)90106-5"},{"key":"key\n\t\t\t\t20171010161849_BIB7","unstructured":"Aldridge A, Bailey J, Neims AH. The disposition of caffeine during and after pregnancy. Semin Perinatol1981;5:310\u201314."},{"key":"key\n\t\t\t\t20171010161849_BIB8","doi-asserted-by":"crossref","unstructured":"Brazier JL, Ritter J, Berland M, et al. Pharmacokinetics of caffeine during and after pregnancy. Dev Pharmacol Ther1983;6:315\u201322.","DOI":"10.1159\/000457332"},{"key":"key\n\t\t\t\t20171010161849_BIB9","doi-asserted-by":"crossref","unstructured":"Knutti R, Rothweiler H, Schlatter C. The effect of pregnancy on the pharmacokinetics of caffeine. Arch Toxicol Suppl1982;5:187\u201392.","DOI":"10.1007\/978-3-642-68511-8_33"},{"key":"key\n\t\t\t\t20171010161849_BIB10","doi-asserted-by":"crossref","unstructured":"Aldridge A, Aranda JV, Neims AH. Caffeine metabolism in the newborn. Clin Pharmacol Ther1979;25:447\u201353.","DOI":"10.1002\/cpt1979254447"},{"key":"key\n\t\t\t\t20171010161849_BIB11","unstructured":"Weathersbee PS, Lodge JR. Caffeine: its direct and indirect influence on reproduction. J Reprod Med1977;19:55\u201363."},{"key":"key\n\t\t\t\t20171010161849_BIB12","doi-asserted-by":"crossref","unstructured":"Kirkinen P, Jouppila P, Koivula A, et al. The effect of caffeine on placental and fetal blood flow in human pregnancy. Am J Obstet Gynecol1983;147:939\u201342.","DOI":"10.1016\/0002-9378(83)90250-8"},{"key":"key\n\t\t\t\t20171010161849_BIB13","doi-asserted-by":"crossref","unstructured":"Fenster L, Hubbard AE, Swan SH, et al. Caffeinated beverages, decaffeinated coffee, and spontaneous abortion. Epidemiology1997;8:515\u201323.","DOI":"10.1097\/00001648-199709000-00008"},{"key":"key\n\t\t\t\t20171010161849_BIB14","doi-asserted-by":"crossref","unstructured":"Signorello LB, McLaughlin JK. Maternal caffeine consumption and spontaneous abortion: a review of the epidemiologic evidence. Epidemiology2004;15:229\u201339.","DOI":"10.1097\/01.ede.0000112221.24237.0c"},{"key":"key\n\t\t\t\t20171010161849_BIB15","doi-asserted-by":"crossref","unstructured":"Olsen J, Melbye M, Olsen SF, et al. The Danish National Birth Cohort\u2014its background, structure and aim. Scand J Public Health2001;29:300\u20137.","DOI":"10.1177\/14034948010290040201"},{"key":"key\n\t\t\t\t20171010161849_BIB16","doi-asserted-by":"crossref","unstructured":"Kramer MS, Liu S, Luo Z, et al. Analysis of perinatal mortality and its components: time for a change? Am J Epidemiol2002;156:493\u20137.","DOI":"10.1093\/aje\/kwf077"},{"key":"key\n\t\t\t\t20171010161849_BIB17","unstructured":"Andersen KV, Helweg-Larsen K, Lange AP. Classification of perinatal and neonatal deaths: fetal, obstetrical and neonatal causes. (In Danish). Ugeskr Laeger1991;153:1494\u20137."},{"key":"key\n\t\t\t\t20171010161849_BIB18","doi-asserted-by":"crossref","unstructured":"Cole SK, Hey EN, Thomson AM. Classifying perinatal death: an obstetric approach. Br J Obstet Gynaecol1986;93:1204\u201312.","DOI":"10.1111\/j.1471-0528.1986.tb07853.x"},{"key":"key\n\t\t\t\t20171010161849_BIB19","doi-asserted-by":"crossref","unstructured":"Hey EN, Lloyd DJ, Wigglesworth JS. Classifying perinatal death: fetal and neonatal factors. Br J Obstet Gynaecol1986;93:1213\u201323.","DOI":"10.1111\/j.1471-0528.1986.tb07854.x"},{"key":"key\n\t\t\t\t20171010161849_BIB20","doi-asserted-by":"crossref","unstructured":"Marsal K, Persson PH, Larsen T, et al. Intrauterine growth curves based on ultrasonically estimated foetal weights. Acta Paediatr1996;85:843\u20138.","DOI":"10.1111\/j.1651-2227.1996.tb14164.x"},{"key":"key\n\t\t\t\t20171010161849_BIB21","doi-asserted-by":"crossref","unstructured":"Bunker ML, McWilliams M. Caffeine content of common beverages. J Am Diet Assoc1979;74:28\u201332.","DOI":"10.1016\/S0002-8223(21)39775-9"},{"key":"key\n\t\t\t\t20171010161849_BIB22","doi-asserted-by":"crossref","unstructured":"Little RE, Weinberg CR. Risk factors for antepartum and intrapartum stillbirth. Am J Epidemiol1993;137:1177\u201389.","DOI":"10.1093\/oxfordjournals.aje.a116620"},{"key":"key\n\t\t\t\t20171010161849_BIB23","doi-asserted-by":"crossref","unstructured":"Wisborg K, Kesmodel U, Henriksen TB, et al. Exposure to tobacco smoke in utero and the risk of stillbirth and death in the first year of life. Am J Epidemiol2001;154:322\u20137.","DOI":"10.1093\/aje\/154.4.322"},{"key":"key\n\t\t\t\t20171010161849_BIB24","doi-asserted-by":"crossref","unstructured":"Kesmodel U, Wisborg K, Olsen SF, et al. Moderate alcohol intake during pregnancy and the risk of stillbirth and death in the first year of life. Am J Epidemiol2002;155:305\u201312.","DOI":"10.1093\/aje\/155.4.305"},{"key":"key\n\t\t\t\t20171010161849_BIB25","doi-asserted-by":"crossref","unstructured":"Cedergren MI. Maternal morbid obesity and the risk of adverse pregnancy outcome. Obstet Gynecol2004;103:219\u201324.","DOI":"10.1097\/01.AOG.0000107291.46159.00"},{"key":"key\n\t\t\t\t20171010161849_BIB26","doi-asserted-by":"crossref","unstructured":"Stephansson O, Dickman PW, Johansson AL, et al. The influence of socioeconomic status on stillbirth risk in Sweden. Int J Epidemiol2001;30:1296\u2013301.","DOI":"10.1093\/ije\/30.6.1296"},{"key":"key\n\t\t\t\t20171010161849_BIB27","doi-asserted-by":"crossref","unstructured":"Simpson JL, Mills JL, Holmes LB, et al. Low fetal loss rates after ultrasound-proved viability in early pregnancy. JAMA1987;258:2555\u20137.","DOI":"10.1001\/jama.258.18.2555"},{"key":"key\n\t\t\t\t20171010161849_BIB28","unstructured":"Stata Corporation. Stata statistical software, release 8.0. College Station, TX: Stata Corporation, 2003."},{"key":"key\n\t\t\t\t20171010161849_BIB29","doi-asserted-by":"crossref","unstructured":"Giannelli M, Doyle P, Roman E, et al. The effect of caffeine consumption and nausea on the risk of miscarriage. Paediatr Perinat Epidemiol2003;17:316\u201323.","DOI":"10.1046\/j.1365-3016.2003.00523.x"},{"key":"key\n\t\t\t\t20171010161849_BIB30","doi-asserted-by":"crossref","unstructured":"Rasch V. Cigarette, alcohol, and caffeine consumption: risk factors for spontaneous abortion. Acta Obstet Gynecol Scand2003;82:182\u20138.","DOI":"10.1034\/j.1600-0412.2003.00078.x"},{"key":"key\n\t\t\t\t20171010161849_BIB31","doi-asserted-by":"crossref","unstructured":"Infante-Rivard C, Fernandez A, Gauthier R, et al. Fetal loss associated with caffeine intake before and during pregnancy. JAMA1993;270:2940\u20133.","DOI":"10.1001\/jama.270.24.2940"},{"key":"key\n\t\t\t\t20171010161849_BIB32","doi-asserted-by":"crossref","unstructured":"Dlugosz L, Belanger K, Hellenbrand K, et al. Maternal caffeine consumption and spontaneous abortion: a prospective cohort study. Epidemiology1996;7:250\u20135.","DOI":"10.1097\/00001648-199605000-00006"},{"key":"key\n\t\t\t\t20171010161849_BIB33","doi-asserted-by":"crossref","unstructured":"Fenster L, Eskenazi B, Windham GC, et al. Caffeine consumption during pregnancy and spontaneous abortion. Epidemiology1991;2:168\u201374.","DOI":"10.1097\/00001648-199105000-00002"},{"key":"key\n\t\t\t\t20171010161849_BIB34","doi-asserted-by":"crossref","unstructured":"Srisuphan W, Bracken MB. Caffeine consumption during pregnancy and association with late spontaneous abortion. Am J Obstet Gynecol1986;154:14\u201320.","DOI":"10.1016\/0002-9378(86)90385-6"},{"key":"key\n\t\t\t\t20171010161849_BIB35","doi-asserted-by":"crossref","unstructured":"Dominguez-Rojas V, Juanes-Pardo JR, Astasio-Arbiza P, et al. Spontaneous abortion in a hospital population: are tobacco and coffee intake risk factors? Eur J Epidemiol1994;10:665\u20138.","DOI":"10.1007\/BF01719278"},{"key":"key\n\t\t\t\t20171010161849_BIB36","doi-asserted-by":"crossref","unstructured":"Wen W, Shu XO, Jacobs DR, et al. The associations of maternal caffeine consumption and nausea with spontaneous abortion. Epidemiology2001;12:38\u201342.","DOI":"10.1097\/00001648-200101000-00008"},{"key":"key\n\t\t\t\t20171010161849_BIB37","doi-asserted-by":"crossref","unstructured":"Tolstrup JS, Kjaer SK, Munk C, et al. Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion? Hum Reprod2003;18:2704\u201310.","DOI":"10.1093\/humrep\/deg480"},{"key":"key\n\t\t\t\t20171010161849_BIB38","doi-asserted-by":"crossref","unstructured":"Mills JL, Holmes LB, Aarons JH, et al. Moderate caffeine use and the risk of spontaneous abortion and intrauterine growth retardation. JAMA1993;269:593\u20137.","DOI":"10.1001\/jama.269.5.593"},{"key":"key\n\t\t\t\t20171010161849_BIB39","doi-asserted-by":"crossref","unstructured":"Parazzini F, Bocciolone L, Fedele L, et al. Risk factors for spontaneous abortion. Int J Epidemiol1991;20:157\u201361.","DOI":"10.1093\/ije\/20.1.157"},{"key":"key\n\t\t\t\t20171010161849_BIB40","doi-asserted-by":"crossref","unstructured":"Kline J, Levin B, Silverman J, et al. Caffeine and spontaneous abortion of known karyotype. Epidemiology1991;2:409\u201317.","DOI":"10.1097\/00001648-199111000-00004"},{"key":"key\n\t\t\t\t20171010161849_BIB41","doi-asserted-by":"crossref","unstructured":"Bracken MB, Triche E, Grosso L, et al. Heterogeneity in assessing self-reports of caffeine exposure: implications for studies of health effects. Epidemiology2002;13:165\u201371.","DOI":"10.1097\/00001648-200203000-00011"},{"key":"key\n\t\t\t\t20171010161849_BIB42","doi-asserted-by":"crossref","unstructured":"Klebanoff MA, Levine RJ, DerSimonian R, et al. Serum caffeine and paraxanthine as markers for reported caffeine intake in pregnancy. Ann Epidemiol1998;8:107\u201311.","DOI":"10.1016\/S1047-2797(97)00125-7"},{"key":"key\n\t\t\t\t20171010161849_BIB43","doi-asserted-by":"crossref","unstructured":"Klebanoff MA, Levine RJ, DerSimonian R, et al. Maternal serum paraxanthine, a caffeine metabolite, and the risk of spontaneous abortion. N Engl J Med1999;341:1639\u201344.","DOI":"10.1056\/NEJM199911253412202"},{"key":"key\n\t\t\t\t20171010161849_BIB44","unstructured":"Danish Coffee Information. The quantum of instant coffee in total coffee consumption, 2005. (In Danish). Copenhagen, Denmark: Danish Coffee Information, 2005. (http:\/\/www.kaffeinfo.dk\/tal\/80_instant_andel.html)."},{"key":"key\n\t\t\t\t20171010161849_BIB45","doi-asserted-by":"crossref","unstructured":"Parazzini F, Chatenoud L, Di Cintio E, et al. Coffee consumption and risk of hospitalized miscarriage before 12 weeks of gestation. Hum Reprod1998;13:2286\u201391.","DOI":"10.1093\/humrep\/13.8.2286"},{"key":"key\n\t\t\t\t20171010161849_BIB46","doi-asserted-by":"crossref","unstructured":"Andrews T, Dunlop W, Roberts DF. Cytogenetic studies in spontaneous abortuses. Hum Genet1984;66:77\u201384.","DOI":"10.1007\/BF00275191"},{"key":"key\n\t\t\t\t20171010161849_BIB47","doi-asserted-by":"crossref","unstructured":"Hogge WA, Byrnes AL, Lanasa MC, et al. The clinical use of karyotyping spontaneous abortions. Am J Obstet Gynecol2003;189:397\u2013400.","DOI":"10.1067\/S0002-9378(03)00700-2"},{"key":"key\n\t\t\t\t20171010161849_BIB48","doi-asserted-by":"crossref","unstructured":"Stein Z, Susser M. Miscarriage, caffeine, and the epiphenomena of pregnancy: the causal model. (Editorial). Epidemiology1991;2:163\u20137.","DOI":"10.1097\/00001648-199107000-00017"},{"key":"key\n\t\t\t\t20171010161849_BIB49","doi-asserted-by":"crossref","unstructured":"Furneaux EC, Langley-Evans AJ, Langley-Evans SC. Nausea and vomiting of pregnancy: endocrine basis and contribution to pregnancy outcome. Obstet Gynecol Surv2001;56:775\u201382.","DOI":"10.1097\/00006254-200112000-00004"},{"key":"key\n\t\t\t\t20171010161849_BIB50","doi-asserted-by":"crossref","unstructured":"Mu J, Kanzaki T, Si X, et al. Apoptosis and related proteins in placenta of intrauterine fetal death in prostaglandin F receptor-deficient mice. Biol Reprod2003;68:1968\u201374.","DOI":"10.1095\/biolreprod.102.008029"},{"key":"key\n\t\t\t\t20171010161849_BIB51","doi-asserted-by":"crossref","unstructured":"Nomura K, Saito S, Ide K, et al. Caffeine suppresses the expression of the Bcl-2 mRNA in BeWo cell culture and rat placenta. J Nutr Biochem2004;15:342\u20139.","DOI":"10.1016\/j.jnutbio.2003.12.007"},{"key":"key\n\t\t\t\t20171010161849_BIB52","doi-asserted-by":"crossref","unstructured":"Wisborg K, Kesmodel U, Bech BH, et al. Maternal consumption of coffee during pregnancy and stillbirth and infant death in first year of life: prospective study. BMJ2003;326:420.","DOI":"10.1136\/bmj.326.7386.420"}],"container-title":["American Journal of Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/aje\/article-pdf\/162\/10\/983\/143448\/kwi317.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T19:50:51Z","timestamp":1683229851000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/aje\/article\/162\/10\/983\/65244\/Coffee-and-Fetal-Death-A-Cohort-Study-with"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,5]]},"references-count":52,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2005,10,5]]},"published-print":{"date-parts":[[2005,11,15]]}},"URL":"https:\/\/doi.org\/10.1093\/aje\/kwi317","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.12521.470003","asserted-by":"object"}]},"ISSN":["1476-6256","0002-9262"],"issn-type":[{"value":"1476-6256","type":"electronic"},{"value":"0002-9262","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,11,15]]},"published":{"date-parts":[[2005,10,5]]}}}