{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:52:43Z","timestamp":1793379163201,"version":"4.5.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,1]]},"DOI":"10.1093\/aje\/kws330","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T06:27:58Z","timestamp":1365056878000},"page":"923-932","source":"Crossref","is-referenced-by-count":82,"title":["Association of Functional Polymorphism rs2231142 (Q141K) in the ABCG2 Gene With Serum Uric Acid and Gout in 4 US Populations"],"prefix":"10.1093","volume":"177","author":[{"given":"Lili","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylee L.","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Saroja","family":"Voruganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal W.","family":"Jorgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Fornage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyle G.","family":"Best","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin D.","family":"Brown-Gentry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley A.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana C.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Deelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Franceschini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo L.","family":"Gaffo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly R.","family":"Glenn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Heiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy S.","family":"Jenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kottgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara C.","family":"Matise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari E.","family":"North","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason G.","family":"Umans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. H. Linda","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,4,3]]},"reference":[{"issue":"9711","key":"key\n\t\t\t\t20170522090401_KWS330C1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0140-6736(09)60883-7","article-title":"Gout","volume":"375","author":"Richette","year":"2010","journal-title":"Lancet"},{"issue":"8","key":"key\n\t\t\t\t20170522090401_KWS330C2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/ncprheum0556","article-title":"The changing epidemiology of gout","volume":"3","author":"Roddy","year":"2007","journal-title":"Nat Clin Pract Rheumatol"},{"issue":"1","key":"key\n\t\t\t\t20170522090401_KWS330C3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/art.23176","article-title":"Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II","volume":"58","author":"Lawrence","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"3","key":"key\n\t\t\t\t20170522090401_KWS330C4","first-page":"498","article-title":"Gout in ambulatory care settings in the United States","volume":"35","author":"Krishnan","year":"2008","journal-title":"J Rheumatol"},{"issue":"2","key":"key\n\t\t\t\t20170522090401_KWS330C5","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/acr.20065","article-title":"Hyperuricemia and coronary heart disease: a systematic review and meta-analysis","volume":"62","author":"Kim","year":"2010","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"17","key":"key\n\t\t\t\t20170522090401_KWS330C6","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1056\/NEJMra0800885","article-title":"Uric acid and cardiovascular risk","volume":"359","author":"Feig","year":"2008","journal-title":"N Engl J Med"},{"issue":"6","key":"key\n\t\t\t\t20170522090401_KWS330C7","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1161\/01.HYP.0000069700.62727.C5","article-title":"Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?","volume":"41","author":"Johnson","year":"2003","journal-title":"Hypertension"},{"issue":"200","key":"key\n\t\t\t\t20170522090401_KWS330C8","first-page":"1","article-title":"Current estimates from the National Health Interview Survey, 1996","author":"Adams","year":"1999","journal-title":"Vital Health Stat 10"},{"issue":"suppl 5","key":"key\n\t\t\t\t20170522090401_KWS330C9","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.3949\/ccjm.75.Suppl_5.S9","article-title":"Epidemiology of gout","volume":"75","author":"Weaver","year":"2008","journal-title":"Cleve Clin J Med"},{"issue":"11","key":"key\n\t\t\t\t20170522090401_KWS330C10","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.metabol.2005.05.007","article-title":"Genome-wide search for genes affecting serum uric acid levels: the Framingham Heart Study","volume":"54","author":"Yang","year":"2005","journal-title":"Metabolism"},{"issue":"11","key":"key\n\t\t\t\t20170522090401_KWS330C11","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1371\/journal.pgen.0030194","article-title":"The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts","volume":"3","author":"Li","year":"2007","journal-title":"PLoS Genet"},{"issue":"4","key":"key\n\t\t\t\t20170522090401_KWS330C12","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/ng.106","article-title":"SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout","volume":"40","author":"Vitart","year":"2008","journal-title":"Nat Genet"},{"issue":"4","key":"key\n\t\t\t\t20170522090401_KWS330C13","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/ng.107","article-title":"SLC2A9 influences uric acid concentrations with pronounced sex-specific effects","volume":"40","author":"Doring","year":"2008","journal-title":"Nat Genet"},{"issue":"9654","key":"key\n\t\t\t\t20170522090401_KWS330C14","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/S0140-6736(08)61343-4","article-title":"Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study","volume":"372","author":"Dehghan","year":"2008","journal-title":"Lancet"},{"issue":"6","key":"key\n\t\t\t\t20170522090401_KWS330C15","doi-asserted-by":"crossref","first-page":"e1000504","DOI":"10.1371\/journal.pgen.1000504","article-title":"Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations","volume":"5","author":"Kolz","year":"2009","journal-title":"PLoS Genet"},{"issue":"1","key":"key\n\t\t\t\t20170522090401_KWS330C16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ajhg.2007.11.001","article-title":"Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia","volume":"82","author":"Wallace","year":"2008","journal-title":"Am J Hum Genet"},{"issue":"11","key":"key\n\t\t\t\t20170522090401_KWS330C17","doi-asserted-by":"crossref","first-page":"e7729","DOI":"10.1371\/journal.pone.0007729","article-title":"Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease","volume":"4","author":"Stark","year":"2009","journal-title":"PLoS One"},{"issue":"2","key":"key\n\t\t\t\t20170522090401_KWS330C18","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.atherosclerosis.2009.12.013","article-title":"Sex and age interaction with genetic association of atherogenic uric acid concentrations","volume":"210","author":"Brandstatter","year":"2010","journal-title":"Atherosclerosis"},{"issue":"8","key":"key\n\t\t\t\t20170522090401_KWS330C19","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/rheumatology\/keq096","article-title":"The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people","volume":"49","author":"Yamagishi","year":"2010","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"key\n\t\t\t\t20170522090401_KWS330C20","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1159\/000318943","article-title":"Association of four genetic loci with uric acid levels and reduced renal function: the J-SHIPP Suita study","volume":"32","author":"Tabara","year":"2010","journal-title":"Am J Nephrol"},{"issue":"24","key":"key\n\t\t\t\t20170522090401_KWS330C21","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1093\/hmg\/ddq412","article-title":"A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Maori, case and control sample sets","volume":"19","author":"Phipps-Green","year":"2010","journal-title":"Hum Mol Genet"},{"issue":"5","key":"key\n\t\t\t\t20170522090401_KWS330C22","doi-asserted-by":"crossref","first-page":"5ra11","DOI":"10.1126\/scitranslmed.3000237","article-title":"Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population","volume":"1","author":"Matsuo","year":"2009","journal-title":"Sci Transl Med"},{"issue":"25","key":"key\n\t\t\t\t20170522090401_KWS330C23","doi-asserted-by":"crossref","first-page":"10338","DOI":"10.1073\/pnas.0901249106","article-title":"Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout","volume":"106","author":"Woodward","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"key\n\t\t\t\t20170522090401_KWS330C24","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/aje\/kwr160","article-title":"The next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study","volume":"174","author":"Matise","year":"2011","journal-title":"Am J Epidemiol"},{"issue":"4","key":"key\n\t\t\t\t20170522090401_KWS330C25","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/oxfordjournals.aje.a115184","article-title":"The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives.","volume":"129","author":"The ARIC vestigators","year":"1989","journal-title":"Am J Epidemiol"},{"issue":"11","key":"key\n\t\t\t\t20170522090401_KWS330C26","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/0895-4356(88)90080-7","article-title":"CARDIA: study design, recruitment, and some characteristics of the examined subjects","volume":"41","author":"Friedman","year":"1988","journal-title":"J Clin Epidemiol"},{"issue":"3","key":"key\n\t\t\t\t20170522090401_KWS330C27","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/1047-2797(91)90005-W","article-title":"The Cardiovascular Health Study: design and rationale","volume":"1","author":"Fried","year":"1991","journal-title":"Ann Epidemiol"},{"issue":"6","key":"key\n\t\t\t\t20170522090401_KWS330C28","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1093\/oxfordjournals.aje.a115757","article-title":"The Strong Heart Study: a study of cardiovascular disease in American Indians. Design and methods","volume":"132","author":"Lee","year":"1990","journal-title":"Am J Epidemiol"},{"issue":"5","key":"key\n\t\t\t\t20170522090401_KWS330C29","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00439-009-0716-8","article-title":"Genetic influence on variation in serum uric acid in American Indians: the Strong Heart Family Study","volume":"126","author":"Voruganti","year":"2009","journal-title":"Hum Genet"},{"issue":"4","key":"key\n\t\t\t\t20170522090401_KWS330C30","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/aje\/kwf208","article-title":"Genetic and environmental contributions to cardiovascular disease risk in American Indians: the Strong Heart Family Study","volume":"157","author":"North","year":"2003","journal-title":"Am J Epidemiol"},{"issue":"9","key":"key\n\t\t\t\t20170522090401_KWS330C31","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1161\/ATVBAHA.108.170332","article-title":"Coronary artery disease-associated locus on chromosome 9p21 and early markers of atherosclerosis","volume":"28","author":"Samani","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"key\n\t\t\t\t20170522090401_KWS330C32","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3899\/jrheum.100418","article-title":"Reliability and sensitivity of the self-report of physician-diagnosed gout in the Campaign Against Cancer and Heart Disease and the Atherosclerosis Risk in the Community cohorts","volume":"38","author":"McAdams","year":"2011","journal-title":"J Rheumatol"},{"issue":"2","key":"key\n\t\t\t\t20170522090401_KWS330C33","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1469-1809.1986.tb01037.x","article-title":"The use of measured genotype information in the analysis of quantitative phenotypes in man. I. Models and analytical methods","volume":"50","author":"Boerwinkle","year":"1986","journal-title":"Ann Hum Genet"},{"issue":"10","key":"key\n\t\t\t\t20170522090401_KWS330C34","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/ejhg.2008.106","article-title":"Gene-environment interactions for complex traits: definitions, methodological requirements and challenges","volume":"16","author":"Dempfle","year":"2008","journal-title":"Eur J Hum Genet"},{"issue":"5","key":"key\n\t\t\t\t20170522090401_KWS330C35","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.jacc.2007.11.087","article-title":"Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis: a population-based, prospective study","volume":"52","author":"Ye","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"key\n\t\t\t\t20170522090401_KWS330C36","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/CIRCULATIONAHA.106.628875","article-title":"Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis","volume":"115","author":"Lorenz","year":"2007","journal-title":"Circulation"},{"issue":"6","key":"key\n\t\t\t\t20170522090401_KWS330C37","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ng.377","article-title":"Multiple loci associated with indices of renal function and chronic kidney disease","volume":"41","author":"Kottgen","year":"2009","journal-title":"Nat Genet"},{"issue":"1","key":"key\n\t\t\t\t20170522090401_KWS330C38","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1194\/jlr.M500395-JLR200","article-title":"Linkage analysis of LDL cholesterol in American Indian populations: the Strong Heart Family Study","volume":"47","author":"North","year":"2006","journal-title":"J Lipid Res"},{"issue":"suppl 1","key":"key\n\t\t\t\t20170522090401_KWS330C39","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1186\/1471-2156-6-S1-S91","article-title":"The quantitative trait linkage disequilibrium test: a more powerful alternative to the quantitative transmission disequilibrium test for use in the absence of population stratification","volume":"6","author":"Havill","year":"2005","journal-title":"BMC Genet"},{"issue":"6","key":"key\n\t\t\t\t20170522090401_KWS330C40","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/(SICI)1098-2272(1997)14:6<959::AID-GEPI66>3.0.CO;2-K","article-title":"Multipoint oligogenic linkage analysis of quantitative traits","volume":"14","author":"Blangero","year":"1997","journal-title":"Genet Epidemiol"},{"issue":"5","key":"key\n\t\t\t\t20170522090401_KWS330C41","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1086\/301844","article-title":"Multipoint quantitative-trait linkage analysis in general pedigrees","volume":"62","author":"Almasy","year":"1998","journal-title":"Am J Hum Genet"},{"issue":"2","key":"key\n\t\t\t\t20170522090401_KWS330C42","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.echo.2007.11.011","article-title":"Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine","volume":"21","author":"Stein","year":"2008","journal-title":"J Am Soc Echocardiogr"},{"issue":"26","key":"key\n\t\t\t\t20170522090401_KWS330C43","doi-asserted-by":"crossref","first-page":"15665","DOI":"10.1073\/pnas.95.26.15665","article-title":"A multidrug resistance transporter from human MCF-7 breast cancer cells","volume":"95","author":"Doyle","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"key\n\t\t\t\t20170522090401_KWS330C44","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1349-7006.2002.tb02162.x","article-title":"Estrone and 17\u03b2-estradiol reverse breast cancer resistance protein-mediated multidrug resistance","volume":"93","author":"Imai","year":"2002","journal-title":"Jpn J Cancer Res"},{"issue":"2","key":"key\n\t\t\t\t20170522090401_KWS330C45","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1158\/0008-5472.596.65.2","article-title":"Estrogen-mediated post transcriptional down-regulation of breast cancer resistance protein\/ABCG2","volume":"65","author":"Imai","year":"2005","journal-title":"Cancer Res"},{"issue":"2","key":"key\n\t\t\t\t20170522090401_KWS330C46","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s11095-007-9432-z","article-title":"Hormonal regulation of BCRP expression in human placental BeWo cells","volume":"25","author":"Wang","year":"2008","journal-title":"Pharm Res"},{"issue":"10","key":"key\n\t\t\t\t20170522090401_KWS330C47","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1038\/jcbfm.2010.36","article-title":"17-\u03b2-Estradiol: a powerful modulator of blood-brain barrier BCRP activity","volume":"30","author":"Hartz","year":"2010","journal-title":"J Cereb Blood Flow Metab"},{"issue":"5","key":"key\n\t\t\t\t20170522090401_KWS330C48","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1124\/mol.105.011080","article-title":"Sex-dependent expression and activity of the ATP-binding cassette transporter breast cancer resistance protein (BCRP\/ABCG2) in liver","volume":"67","author":"Merino","year":"2005","journal-title":"Mol Pharmacol"},{"issue":"1","key":"key\n\t\t\t\t20170522090401_KWS330C49","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbrc.2004.11.012","article-title":"Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp\/Abcg2) in rats and mice","volume":"326","author":"Tanaka","year":"2005","journal-title":"Biochem Biophys Res Commun"}],"container-title":["American Journal of Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/aje\/article-pdf\/177\/9\/923\/17340377\/kws330.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T09:33:45Z","timestamp":1715160825000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/aje\/article-lookup\/doi\/10.1093\/aje\/kws330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,3]]},"references-count":49,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,4,3]]},"published-print":{"date-parts":[[2013,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/aje\/kws330","relation":{},"ISSN":["1476-6256","0002-9262"],"issn-type":[{"value":"1476-6256","type":"electronic"},{"value":"0002-9262","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4,3]]}}}