{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:13:34Z","timestamp":1780539214457,"version":"3.54.1"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,1]]},"DOI":"10.1093\/aje\/kwt262","type":"journal-article","created":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T23:01:47Z","timestamp":1384556507000},"page":"267-281","source":"Crossref","is-referenced-by-count":26,"title":["Contribution of Transforming Growth Factor \u03b1 Polymorphisms to Nonsyndromic Orofacial Clefts: A HuGE Review and Meta-Analysis"],"prefix":"10.1093","volume":"179","author":[{"given":"Xiao-Cheng","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Lai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-jun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Yu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,11,15]]},"reference":[{"issue":"3","key":"key\n\t\t\t\t20170522092831_KWT262C1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrg2933","article-title":"Cleft lip and palate: understanding genetic and environmental influences","volume":"12","author":"Dixon","year":"2011","journal-title":"Nat Rev Genet"},{"issue":"7","key":"key\n\t\t\t\t20170522092831_KWT262C2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1601-0825.2009.01577.x","article-title":"The genetics of isolated orofacial clefts: from genotypes to subphenotypes","volume":"15","author":"Jugessur","year":"2009","journal-title":"Oral Dis"},{"issue":"9703","key":"key\n\t\t\t\t20170522092831_KWT262C3","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(09)60695-4","article-title":"Cleft lip and palate","volume":"374","author":"Mossey","year":"2009","journal-title":"Lancet"},{"issue":"4","key":"key\n\t\t\t\t20170522092831_KWT262C4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1034\/j.1399-0004.2002.610402.x","article-title":"Gene\/environment causes of cleft lip and\/or palate","volume":"61","author":"Murray","year":"2002","journal-title":"Clin Genet"},{"issue":"3","key":"key\n\t\t\t\t20170522092831_KWT262C5","first-page":"348","article-title":"Association of genetic variation of the transforming growth factor-alpha gene with cleft lip and palate","volume":"45","author":"Ardinger","year":"1989","journal-title":"Am J Hum Genet"},{"issue":"6","key":"key\n\t\t\t\t20170522092831_KWT262C6","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ng.580","article-title":"A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4","volume":"42","author":"Beaty","year":"2010","journal-title":"Nat Genet"},{"issue":"6","key":"key\n\t\t\t\t20170522092831_KWT262C7","first-page":"1377","article-title":"Cleft lip with or without cleft palate: associations with transforming growth factor alpha and retinoic acid receptor loci","volume":"51","author":"Chenevix-Trench","year":"1992","journal-title":"Am J Hum Genet"},{"issue":"9","key":"key\n\t\t\t\t20170522092831_KWT262C8","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1002\/ajmg.a.34169","article-title":"Contribution of variants in and near the IRF6 gene to the risk of nonsyndromic cleft lip with or without cleft palate in a Malay population","volume":"155A","author":"Salahshourifar","year":"2011","journal-title":"Am J Med Genet A"},{"issue":"6-7","key":"key\n\t\t\t\t20170522092831_KWT262C9","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.ejmg.2012.02.006","article-title":"Mutation screening of IRF6 among families with non-syndromic oral clefts and identification of two novel variants: review of the literature","volume":"55","author":"Salahshourifar","year":"2012","journal-title":"Eur J Med Genet"},{"issue":"4","key":"key\n\t\t\t\t20170522092831_KWT262C10","doi-asserted-by":"crossref","first-page":"e35347","DOI":"10.1371\/journal.pone.0035347","article-title":"BMP4 was associated with NSCL\/P in an Asian population","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170522092831_KWT262C11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/1471-2350-12-163","article-title":"Risk variants in BMP4 promoters for nonsyndromic cleft lip\/palate in a Chilean population","volume":"12","author":"Suazo","year":"2011","journal-title":"BMC Med Genet"},{"issue":"9","key":"key\n\t\t\t\t20170522092831_KWT262C12","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1002\/ajmg.a.35503","article-title":"Infants\u2019 MTHFR polymorphisms and nonsyndromic orofacial clefts susceptibility: a meta-analysis based on 17 case-control studies","volume":"158A","author":"Pan","year":"2012","journal-title":"Am J Med Genet A"},{"issue":"12","key":"key\n\t\t\t\t20170522092831_KWT262C13","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1136\/jmg.2009.070029","article-title":"Associations of folate and choline metabolism gene polymorphisms with orofacial clefts","volume":"47","author":"Mostowska","year":"2010","journal-title":"J Med Genet"},{"issue":"1","key":"key\n\t\t\t\t20170522092831_KWT262C14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF01744264","article-title":"Immunolocalization of epidermal growth factor (EGF), EGF receptor and transforming growth factor alpha (TGF alpha) during murine palatogenesis in vivo and in vitro","volume":"184","author":"Dixon","year":"1991","journal-title":"Anat Embryol (Berl)"},{"issue":"4","key":"key\n\t\t\t\t20170522092831_KWT262C15","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/gepi.10268","article-title":"Cleft palate, transforming growth factor alpha gene variants, and maternal exposures: assessing gene-environment interactions in case-parent triads","volume":"25","author":"Jugessur","year":"2003","journal-title":"Genet Epidemiol"},{"issue":"5","key":"key\n\t\t\t\t20170522092831_KWT262C16","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0003-9969(92)90024-3","article-title":"The effects of epidermal growth factor, transforming growth factors alpha and beta and platelet-derived growth factor on murine palatal shelves in organ culture","volume":"37","author":"Dixon","year":"1992","journal-title":"Arch Oral Biol"},{"issue":"3","key":"key\n\t\t\t\t20170522092831_KWT262C17","doi-asserted-by":"crossref","first-page":"765.e1","DOI":"10.1016\/j.urology.2010.04.044","article-title":"Meta-analysis of association between TP53 Arg72Pro polymorphism and bladder cancer risk","volume":"76","author":"Jiang","year":"2010","journal-title":"Urology"},{"issue":"3","key":"key\n\t\t\t\t20170522092831_KWT262C18","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1359\/JBMR.0301265","article-title":"Meta-analysis of molecular association studies: vitamin D receptor gene polymorphisms and BMD as a case study","volume":"19","author":"Thakkinstian","year":"2004","journal-title":"J Bone Miner Res"},{"issue":"3","key":"key\n\t\t\t\t20170522092831_KWT262C19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/aje\/kwi184","article-title":"Systematic review and meta-analysis of the association between \u03b22-adrenoceptor polymorphisms and asthma: a HuGE review","volume":"162","author":"Thakkinstian","year":"2005","journal-title":"Am J Epidemiol"},{"issue":"14","key":"key\n\t\t\t\t20170522092831_KWT262C20","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.1158\/1078-0432.CCR-11-1531","article-title":"Predictive value of XRCC1 gene polymorphisms on platinum-based chemotherapy in advanced non\u2013small cell lung cancer patients: a systematic review and meta-analysis","volume":"18","author":"Wu","year":"2012","journal-title":"Clin Cancer Res"},{"issue":"11","key":"key\n\t\t\t\t20170522092831_KWT262C21","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"issue":"8","key":"key\n\t\t\t\t20170522092831_KWT262C22","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/sim.4780070807","article-title":"A note on graphical presentation of estimated odds ratios from several clinical trials","volume":"7","author":"Galbraith","year":"1988","journal-title":"Stat Med"},{"issue":"6","key":"key\n\t\t\t\t20170522092831_KWT262C23","doi-asserted-by":"crossref","first-page":"R240","DOI":"10.1186\/cc9395","article-title":"Cerebrospinal fluid lactate concentration to distinguish bacterial from aseptic meningitis: a systemic review and meta-analysis","volume":"14","author":"Huy","year":"2010","journal-title":"Crit Care"},{"issue":"7","key":"key\n\t\t\t\t20170522092831_KWT262C24","doi-asserted-by":"crossref","first-page":"e71522","DOI":"10.1371\/journal.pone.0071522","article-title":"Frequency-risk and duration-risk relationships between aspirin use and gastric cancer: a systematic review and meta-analysis","volume":"8","author":"Ye","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"key\n\t\t\t\t20170522092831_KWT262C25","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"issue":"7109","key":"key\n\t\t\t\t20170522092831_KWT262C26","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"issue":"2","key":"key\n\t\t\t\t20170522092831_KWT262C27","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/ajmg.a.33113","article-title":"MTHFR, TGFB3, and TGF\u0391 polymorphisms and their association with the risk of non-syndromic cleft lip and cleft palate in China","volume":"152A","author":"Zhu","year":"2010","journal-title":"Am J Med Genet A"},{"issue":"3","key":"key\n\t\t\t\t20170522092831_KWT262C28","first-page":"682","article-title":"Cleft lip and palate: no evidence of linkage to transforming growth factor alpha","volume":"49","author":"Hecht","year":"1991","journal-title":"Am J Hum Genet"},{"issue":"4","key":"key\n\t\t\t\t20170522092831_KWT262C29","first-page":"870","article-title":"Genetic variation in transforming growth factor alpha: possible association of BamHI polymorphism with bilateral sporadic cleft lip and palate","volume":"50","author":"Stoll","year":"1992","journal-title":"Am J Hum Genet"},{"issue":"1","key":"key\n\t\t\t\t20170522092831_KWT262C30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF00216150","article-title":"Genetic variation in transforming growth factor alpha: possible association of BamHI polymorphism with bilateral sporadic cleft lip and palate","volume":"92","author":"Stoll","year":"1993","journal-title":"Hum Genet"},{"issue":"6","key":"key\n\t\t\t\t20170522092831_KWT262C31","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S1047-2797(01)00222-8","article-title":"A case-control study of nonsyndromic oral clefts in Maryland","volume":"11","author":"Beaty","year":"2001","journal-title":"Ann Epidemiol"},{"issue":"1","key":"key\n\t\t\t\t20170522092831_KWT262C32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1597\/1545-1569(1997)034<0001:SOTCGT>2.3.CO;2","article-title":"Studies of the candidate genes TGFB2, MSX1, TGF\u0391, and TGFB3 in the etiology of cleft lip and palate in the Philippines","volume":"34","author":"Lidral","year":"1997","journal-title":"Cleft Palate Craniofac J"},{"issue":"2","key":"key\n\t\t\t\t20170522092831_KWT262C33","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1086\/301956","article-title":"Association of MSX1 and TGFB3 with nonsyndromic clefting in humans","volume":"63","author":"Lidral","year":"1998","journal-title":"Am J Hum Genet"},{"issue":"4","key":"key\n\t\t\t\t20170522092831_KWT262C34","first-page":"836","article-title":"Association of transforming growth-factor alpha gene polymorphisms with nonsyndromic cleft palate only (CPO)","volume":"53","author":"Shiang","year":"1993","journal-title":"Am J Hum Genet"},{"issue":"5","key":"key\n\t\t\t\t20170522092831_KWT262C35","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1597\/1545-1569(1997)034<0447:TFIBMS>2.3.CO;2","article-title":"Testing for interaction between maternal smoking and TGF\u0391 genotype among oral cleft cases born in Maryland 1992\u20131996","volume":"34","author":"Beaty","year":"1997","journal-title":"Cleft Palate Craniofac J"},{"issue":"5","key":"key\n\t\t\t\t20170522092831_KWT262C36","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/ajmg.1320450508","article-title":"Association between alleles of the transforming growth factor-alpha locus and the occurrence of cleft lip","volume":"45","author":"Sassani","year":"1993","journal-title":"Am J Med Genet"},{"issue":"3","key":"key\n\t\t\t\t20170522092831_KWT262C37","first-page":"551","article-title":"Orofacial clefts, parental cigarette smoking, and transforming growth factor-alpha gene variants","volume":"58","author":"Shaw","year":"1996","journal-title":"Am J Hum Genet"},{"issue":"5","key":"key\n\t\t\t\t20170522092831_KWT262C38","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1597\/07-087.1","article-title":"TGF\u0391\/TaqI polymorphism in nonsyndromic cleft lip and palate patients from Rio Grande do Sul, Brazil","volume":"45","author":"Ehlers Bertoja","year":"2008","journal-title":"Cleft Palate Craniofac J"},{"issue":"4","key":"key\n\t\t\t\t20170522092831_KWT262C39","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1597\/03-054.1","article-title":"Transforming growth factor-alpha and nonsyndromic cleft lip with or without palate in Brazilian patients: results of a large case-control study","volume":"41","author":"Passos-Bueno","year":"2004","journal-title":"Cleft Palate Craniofac J"},{"issue":"6","key":"key\n\t\t\t\t20170522092831_KWT262C40","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/jmg.29.6.390","article-title":"Confirmation of an association between RFLPs at the transforming growth factor-alpha locus and non-syndromic cleft lip and palate","volume":"29","author":"Holder","year":"1992","journal-title":"J Med Genet"},{"issue":"5","key":"key\n\t\t\t\t20170522092831_KWT262C41","first-page":"1012","article-title":"Further evidence for an association between genetic variation in transforming growth factor alpha and cleft lip and palate","volume":"48","author":"Chenevix-Trench","year":"1991","journal-title":"Am J Hum Genet"},{"issue":"2","key":"key\n\t\t\t\t20170522092831_KWT262C42","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1042\/cs0990105","article-title":"Analysis of the candidate genes responsible for non-syndromic cleft lip and palate in Japanese people","volume":"99","author":"Tanabe","year":"2000","journal-title":"Clin Sci (Lond)"},{"issue":"3","key":"key\n\t\t\t\t20170522092831_KWT262C43","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/oxfordjournals.aje.a009799","article-title":"Oral clefts, transforming growth factor alpha gene variants, and maternal smoking: a population-based case-control study in Denmark, 1991\u20131994","volume":"149","author":"Christensen","year":"1999","journal-title":"Am J Epidemiol"},{"issue":"7","key":"key\n\t\t\t\t20170522092831_KWT262C44","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/oxfordjournals.aje.a117478","article-title":"Association study of transforming growth factor alpha (TGF alpha) TaqI polymorphism and oral clefts: indication of gene-environment interaction in a population-based sample of infants with birth defects","volume":"141","author":"Hwang","year":"1995","journal-title":"Am J Epidemiol"},{"issue":"4","key":"key\n\t\t\t\t20170522092831_KWT262C45","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/ajmg.1320570406","article-title":"Association between alleles of the transforming growth factor alpha locus and cleft lip and palate in the Chilean population","volume":"57","author":"Jara","year":"1995","journal-title":"Am J Med Genet"},{"issue":"1","key":"key\n\t\t\t\t20170522092831_KWT262C46","first-page":"339","article-title":"Evidence for an association between RFLPs at the transforming growth factor alpha (locus) and nonsyndromic cleft lip\/palate in a South American population","volume":"56","author":"Jara","year":"1995","journal-title":"Am J Hum Genet"},{"issue":"6","key":"key\n\t\t\t\t20170522092831_KWT262C47","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1597\/07-020.1","article-title":"Transforming growth factor-alpha and nonsyndromic cleft lip with or without palate or cleft palate only in Kelantan, Malaysia","volume":"45","author":"Rahman","year":"2008","journal-title":"Cleft Palate Craniofac J"},{"issue":"3","key":"key\n\t\t\t\t20170522092831_KWT262C48","first-page":"285","article-title":"Association of transforming growth factor-\u03b1 gene polymorphism and environment factors with nonsyndromic cleft lip with or without cleft palate in Han nationality [in Chinese]","volume":"25","author":"Yuan","year":"2007","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"issue":"5","key":"key\n\t\t\t\t20170522092831_KWT262C49","first-page":"369","article-title":"Relation between nonsyndromic cleft lip with or without cleft palate in Chinese and TaqI polymorphism of transforming growth factor-\u03b1 [in Chinese]","volume":"36","author":"Cang","year":"2002","journal-title":"J Harbin Medical Univ"},{"issue":"3","key":"key\n\t\t\t\t20170522092831_KWT262C50","first-page":"190","article-title":"The TGF-\u03b1 gene TaqI polymorphism and nonsyndromic cleft lip with or without cleft palate [in Chinese]","volume":"20","author":"Zhang","year":"2004","journal-title":"Chin J Plast Surg"},{"issue":"3","key":"key\n\t\t\t\t20170522092831_KWT262C51","first-page":"185","article-title":"Association of nonsyndromic cleft lip and palate with TGFA gene polymorphisms [in Chinese]","volume":"30","author":"Ma","year":"2007","journal-title":"J Luzhou Med Coll"},{"issue":"6","key":"key\n\t\t\t\t20170522092831_KWT262C52","first-page":"533","article-title":"Relationship between transforming growth factor-\u03b1 gene polymorphism and nonsyndromic cleft lip with cleft palate [in Chinese]","volume":"24","author":"Yuan","year":"2006","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"issue":"4","key":"key\n\t\t\t\t20170522092831_KWT262C53","first-page":"6","article-title":"Association between transforming growth factor-\u03b1 gene variant and nonsyndromic cleft lip with or without cleft palate of Han\/Muslin people in Gansu province [in Chinese]","volume":"37","author":"Zhang","year":"2011","journal-title":"J Lanzhou Univ (Med Sci)"},{"issue":"18","key":"key\n\t\t\t\t20170522092831_KWT262C54","first-page":"2303","article-title":"A study on association between TGF\u0391 gene polymorphism and NSCL\/P susceptibility [in Chinese]","volume":"20","author":"Zhou","year":"2005","journal-title":"Matern Child Health Care China"},{"issue":"2","key":"key\n\t\t\t\t20170522092831_KWT262C55","first-page":"67","article-title":"Association of transforming growth factor-\u03b1 gene polymorphism and environment factors with nonsyndromic cleft lip with or without cleft palate in Han nationality [in Chinese]","volume":"2","author":"Ye","year":"2011","journal-title":"Chin J Women Child Health"},{"issue":"6","key":"key\n\t\t\t\t20170522092831_KWT262C56","first-page":"768","article-title":"Research in the transforming growth factor-\u03b1 gene polymorphism of 43 Han people of simple cleft palate in Guangdong province [in Chinese]","volume":"31","author":"Zhang","year":"2009","journal-title":"Guangxi Med J"},{"issue":"8","key":"key\n\t\t\t\t20170522092831_KWT262C57","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1177\/00220345960750080301","article-title":"Cell proliferation and expression of EGF, TGF-a, and EGF receptor in the developing primary palate","volume":"75","author":"Iamaroon","year":"1996","journal-title":"J Dent Res"},{"issue":"3","key":"key\n\t\t\t\t20170522092831_KWT262C58","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/(SICI)1098-2272(1997)14:3<231::AID-GEPI2>3.0.CO;2-8","article-title":"Transforming growth factor alpha locus and nonsyndromic cleft lip with or without cleft palate: a reappraisal","volume":"14","author":"Mitchell","year":"1997","journal-title":"Genet Epidemiol"},{"issue":"3","key":"key\n\t\t\t\t20170522092831_KWT262C59","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ng749","article-title":"Replication validity of genetic association studies","volume":"29","author":"Ioannidis","year":"2001","journal-title":"Nat Genet"},{"issue":"2","key":"key\n\t\t\t\t20170522092831_KWT262C60","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1086\/422475","article-title":"Meta-analysis of 13 genome scans reveals multiple cleft lip\/palate genes with novel loci on 9q21 and 2q32-35","volume":"75","author":"Marazita","year":"2004","journal-title":"Am J Hum Genet"},{"issue":"9","key":"key\n\t\t\t\t20170522092831_KWT262C61","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1093\/aje\/kwj103","article-title":"Association between the transforming growth factor alpha gene and nonsyndromic oral clefts: a HuGE review","volume":"163","author":"Vieira","year":"2006","journal-title":"Am J Epidemiol"},{"issue":"3","key":"key\n\t\t\t\t20170522092831_KWT262C62","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.gde.2005.03.003","article-title":"Orofacial clefting: recent insights into a complex trait","volume":"15","author":"Jugessur","year":"2005","journal-title":"Curr Opin Genet Dev"},{"issue":"5","key":"key\n\t\t\t\t20170522092831_KWT262C63","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1093\/aje\/kwi214","article-title":"Cleft lip and palate versus cleft lip only: Are they distinct defects?","volume":"162","author":"Harville","year":"2005","journal-title":"Am J Epidemiol"},{"issue":"11","key":"key\n\t\t\t\t20170522092831_KWT262C64","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ng.242","article-title":"Disruption of an AP-2\u03b1 binding site in an IRF6 enhancer is associated with cleft lip","volume":"40","author":"Rahimov","year":"2008","journal-title":"Nat Genet"},{"issue":"3","key":"key\n\t\t\t\t20170522092831_KWT262C65","first-page":"213","article-title":"Tobacco smoking and oral clefts: a meta-analysis","volume":"82","author":"Little","year":"2004","journal-title":"Bull World Health Organ"},{"issue":"2","key":"key\n\t\t\t\t20170522092831_KWT262C66","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/01.ede.0000254430.61294.c0","article-title":"Maternal smoking and environmental tobacco smoke exposure and the risk of orofacial clefts","volume":"18","author":"Honein","year":"2007","journal-title":"Epidemiology"},{"issue":"9","key":"key\n\t\t\t\t20170522092831_KWT262C67","doi-asserted-by":"crossref","first-page":"e45441","DOI":"10.1371\/journal.pone.0045441","article-title":"Interaction between IRF6 and TGF\u0391 genes contribute to the risk of nonsyndromic cleft lip\/palate","volume":"7","author":"Letra","year":"2012","journal-title":"PLoS One"}],"container-title":["American Journal of Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/aje\/article-pdf\/179\/3\/267\/17341632\/kwt262.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T10:16:44Z","timestamp":1503397004000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/aje\/article-lookup\/doi\/10.1093\/aje\/kwt262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,15]]},"references-count":67,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,11,15]]},"published-print":{"date-parts":[[2014,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/aje\/kwt262","relation":{},"ISSN":["1476-6256","0002-9262"],"issn-type":[{"value":"1476-6256","type":"electronic"},{"value":"0002-9262","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11,15]]}}}