{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:39:48Z","timestamp":1792089588876,"version":"4.4.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T00:00:00Z","timestamp":1526256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Science and Technology Major Project","award":["2018ZX10723203"],"award-info":[{"award-number":["2018ZX10723203"]}]},{"name":"National Science and Technology Major Project","award":["2018ZX10302206"],"award-info":[{"award-number":["2018ZX10302206"]}]},{"name":"Shanghai Municipal Education Commission\u2013Gaofeng Clinical Medicine and Shanghai Municipal Government","award":["GZ1263"],"award-info":[{"award-number":["GZ1263"]}]},{"name":"Shanghai Municipal Education Commission\u2013Gaofeng Clinical Medicine and Shanghai Municipal Government","award":["81470869"],"award-info":[{"award-number":["81470869"]}]},{"name":"Shanghai Municipal Education Commission\u2013Gaofeng Clinical Medicine and Shanghai Municipal Government","award":["81670576"],"award-info":[{"award-number":["81670576"]}]},{"name":"Shanghai Municipal Education Commission\u2013Gaofeng Clinical Medicine and Shanghai Municipal Government","award":["81330038"],"award-info":[{"award-number":["81330038"]}]},{"name":"Shanghai Municipal Education Commission\u2013Gaofeng Clinical Medicine and Shanghai Municipal Government","award":["81401665"],"award-info":[{"award-number":["81401665"]}]},{"name":"Shanghai Municipal Education Commission\u2013Gaofeng Clinical Medicine and Shanghai Municipal Government","award":["81270533"],"award-info":[{"award-number":["81270533"]}]},{"name":"Shanghai Municipal Education Commission\u2013Gaofeng Clinical Medicine and Shanghai Municipal Government","award":["81470038"],"award-info":[{"award-number":["81470038"]}]},{"name":"Shanghai Municipal Education Commission\u2013Gaofeng Clinical Medicine and Shanghai Municipal Government","award":["81271884"],"award-info":[{"award-number":["81271884"]}]},{"name":"Shanghai Municipal Education Commission\u2013Gaofeng Clinical Medicine and Shanghai Municipal Government","award":["81461130019"],"award-info":[{"award-number":["81461130019"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["GZ1263"],"award-info":[{"award-number":["GZ1263"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470869"],"award-info":[{"award-number":["81470869"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670576"],"award-info":[{"award-number":["81670576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81330038"],"award-info":[{"award-number":["81330038"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401665"],"award-info":[{"award-number":["81401665"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270533"],"award-info":[{"award-number":["81270533"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470038"],"award-info":[{"award-number":["81470038"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271884"],"award-info":[{"award-number":["81271884"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81461130019"],"award-info":[{"award-number":["81461130019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,1]]},"DOI":"10.1093\/aje\/kwy083","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T07:09:24Z","timestamp":1522912164000},"page":"1829-1839","source":"Crossref","is-referenced-by-count":64,"title":["Acute-on-Chronic Liver Failure in China: Rationale for Developing a Patient Registry and Baseline Characteristics"],"prefix":"10.1093","volume":"187","author":[{"given":"Wen-yi","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Shanghai Institute of Digestive Disease, Shanghai, China"},{"name":"Key Laboratory of Gastroenterology and Hepatology, Chinese Ministry of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Southwest Hospital, Third Military Medical University"},{"name":"Chinese Chronic Liver Failure Consortium, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Chinese Chronic Liver Failure Consortium, China"},{"name":"Department of Infectious Diseases, Institute of Infection and Immunology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Chinese Chronic Liver Failure Consortium, China"},{"name":"Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese Chronic Liver Failure Consortium, China"},{"name":"Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Chinese Chronic Liver Failure Consortium, China"},{"name":"Department of Infectious Disease, Hunan Key Laboratory of Viral Hepatitis, Xiangya Hospital, Central South University, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-hang","family":"Gao","sequence":"additional","affiliation":[{"name":"Chinese Chronic Liver Failure Consortium, China"},{"name":"Department of Hepatology, First Hospital of Jilin University, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-ji","family":"Meng","sequence":"additional","affiliation":[{"name":"Chinese Chronic Liver Failure Consortium, China"},{"name":"Department of Infectious Disease, Taihe Hospital, Hubei University of Medicine, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-ping","family":"Qian","sequence":"additional","affiliation":[{"name":"Chinese Chronic Liver Failure Consortium, China"},{"name":"Department of Liver Intensive Care Unit, Shanghai Public Health Clinical Centre, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Chinese Chronic Liver Failure Consortium, China"},{"name":"Department of Infectious Diseases and Hepatology, Second Hospital of Shandong University, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-bo","family":"Lu","sequence":"additional","affiliation":[{"name":"Chinese Chronic Liver Failure Consortium, China"},{"name":"Liver Disease Center, First Affiliated Hospital of Xinjiang Medical University, Xinjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Shang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Gastroenterology and Hepatology, Chinese Ministry of Health"},{"name":"Department of Infectious Disease, Henan Provincial People\u2019s Hospital, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Shanghai Institute of Digestive Disease, Shanghai, China"},{"name":"Key Laboratory of Gastroenterology and Hepatology, Chinese Ministry of Health"},{"name":"Chinese Chronic Liver Failure Consortium, China"},{"name":"Infectious Disease Center, Affiliated Hospital of Logistics University of People\u2019s Armed Police Force, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Fuzhou General Hospital of Nanjing Military Command, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Sun","sequence":"additional","affiliation":[{"name":"Chinese Evidence-Based Medicine Center and Clinical Research, Evaluation and Translation Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Shanghai Institute of Digestive Disease, Shanghai, China"},{"name":"Key Laboratory of Gastroenterology and Hepatology, Chinese Ministry of Health"},{"name":"Chinese Chronic Liver Failure Consortium, China"},{"name":"Infectious Disease Center, Affiliated Hospital of Logistics University of People\u2019s Armed Police Force, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,5,14]]},"reference":[{"issue":"10003","key":"key\n\t\t\t\t20180831110357_kwy083C1","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/S0140-6736(15)00309-8","article-title":"Acute-on-chronic liver failure","volume":"386","author":"Bernal","year":"2015","journal-title":"Lancet"},{"issue":"1 suppl","key":"key\n\t\t\t\t20180831110357_kwy083C2","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1016\/j.jhep.2014.11.045","article-title":"Acute-on-chronic liver failure: a new syndrome that will re-classify cirrhosis","volume":"62","author":"Arroyo","year":"2015","journal-title":"J Hepatol"},{"issue":"7","key":"key\n\t\t\t\t20180831110357_kwy083C3","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1053\/j.gastro.2013.02.042","article-title":"Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis","volume":"144","author":"Moreau","year":"2013","journal-title":"Gastroenterology"},{"issue":"1","key":"key\n\t\t\t\t20180831110357_kwy083C4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jhep.2015.01.029","article-title":"Submassive hepatic necrosis distinguishes HBV-associated acute on chronic liver failure from cirrhotic patients with acute decompensation","volume":"63","author":"Li","year":"2015","journal-title":"J Hepatol"},{"issue":"1","key":"key\n\t\t\t\t20180831110357_kwy083C5","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/hep.27795","article-title":"Acute-on-chronic liver failure precipitated by hepatic injury is distinct from that precipitated by extrahepatic insults","volume":"62","author":"Shi","year":"2015","journal-title":"Hepatology"},{"issue":"6","key":"key\n\t\t\t\t20180831110357_kwy083C6","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1002\/hep.28812","article-title":"Time trends in the health care burden and mortality of acute on chronic liver failure in the United States","volume":"64","author":"Allen","year":"2016","journal-title":"Hepatology"},{"issue":"5","key":"key\n\t\t\t\t20180831110357_kwy083C7","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.jhep.2011.12.014","article-title":"The impact of organ dysfunction in cirrhosis: survival at a cost?","volume":"56","author":"Shawcross","year":"2012","journal-title":"J Hepatol"},{"issue":"5","key":"key\n\t\t\t\t20180831110357_kwy083C8","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1002\/hep.24622","article-title":"Intensive care of the patient with cirrhosis","volume":"54","author":"Olson","year":"2011","journal-title":"Hepatology"},{"issue":"3","key":"key\n\t\t\t\t20180831110357_kwy083C9","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s12072-014-9585-x","article-title":"Criteria for liver transplantation in ACLF and outcome","volume":"9","author":"Chan","year":"2015","journal-title":"Hepatol Int"},{"issue":"2","key":"key\n\t\t\t\t20180831110357_kwy083C10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1055\/s-0036-1583197","article-title":"Extracorporeal liver support and liver transplant for patients with acute-on-chronic liver failure","volume":"36","author":"Li","year":"2016","journal-title":"Semin Liver Dis"},{"issue":"4","key":"key\n\t\t\t\t20180831110357_kwy083C11","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/hep.28740","article-title":"Systemic inflammation in decompensated cirrhosis: characterization and role in acute-on-chronic liver failure","volume":"64","author":"Cl\u00e0ria","year":"2016","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t20180831110357_kwy083C12","doi-asserted-by":"crossref","first-page":"25487","DOI":"10.1038\/srep25487","article-title":"Characteristics, diagnosis and prognosis of acute-on-chronic liver failure in cirrhosis associated to Hepatitis B","volume":"6","author":"Li","year":"2016","journal-title":"Sci Rep"},{"issue":"4","key":"key\n\t\t\t\t20180831110357_kwy083C13","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s12072-014-9580-2","article-title":"Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014","volume":"8","author":"Sarin","year":"2014","journal-title":"Hepatol Int"},{"key":"key\n\t\t\t\t20180831110357_kwy083C14","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s12072-008-9106-x","article-title":"Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL)","volume":"3","author":"Sarin","year":"2009","journal-title":"Hepatol Int"},{"issue":"10","key":"key\n\t\t\t\t20180831110357_kwy083C15","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1111\/liv.13443","article-title":"Development of predisposition, injury, response, organ failure model for predicting acute kidney injury in acute on chronic liver failure","volume":"37","author":"Maiwall","year":"2017","journal-title":"Liver Int"},{"issue":"5","key":"key\n\t\t\t\t20180831110357_kwy083C16","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s12072-017-9816-z","article-title":"Liver failure determines the outcome in patients of acute-on-chronic liver failure (ACLF): comparison of APASL ACLF research consortium (AARC) and CLIF-SOFA models","volume":"11","author":"Choudhury","year":"2017","journal-title":"Hepatol Int"},{"issue":"12","key":"key\n\t\t\t\t20180831110357_kwy083C17","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1111\/jgh.13799","article-title":"Systemic inflammatory response syndrome in acute-on-chronic liver failure: relevance of \u201dgolden window\u201d: a prospective study","volume":"32","author":"Choudhury","year":"2017","journal-title":"J Gastroenterol Hepatol"},{"issue":"3","key":"key\n\t\t\t\t20180831110357_kwy083C18","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jceh.2017.05.002","article-title":"Toward a better definition of acute-on-chronic liver failure","volume":"7","author":"Duseja","year":"2017","journal-title":"J Clin Exp Hepatol"},{"issue":"2","key":"key\n\t\t\t\t20180831110357_kwy083C19","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1055\/s-0036-1583198","article-title":"Management of acute-on-chronic liver failure","volume":"36","author":"Durand","year":"2016","journal-title":"Semin Liver Dis"},{"issue":"1","key":"key\n\t\t\t\t20180831110357_kwy083C20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1053\/j.gastro.2014.05.005","article-title":"Toward an improved definition of acute-on-chronic liver failure","volume":"147","author":"Jalan","year":"2014","journal-title":"Gastroenterology"},{"issue":"6","key":"key\n\t\t\t\t20180831110357_kwy083C21","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.diii.2017.03.003","article-title":"Liver fibrosis, cirrhosis, and cirrhosis-related nodules: imaging diagnosis and surveillance","volume":"98","author":"Aub\u00e9","year":"2017","journal-title":"Diagn Interv Imaging"},{"issue":"1","key":"key\n\t\t\t\t20180831110357_kwy083C22","doi-asserted-by":"crossref","first-page":"e0146745","DOI":"10.1371\/journal.pone.0146745","article-title":"Characteristics and discrepancies in acute-on-chronic liver failure: need for a unified definition","volume":"11","author":"Kim","year":"2016","journal-title":"PLoS One"},{"issue":"10","key":"key\n\t\t\t\t20180831110357_kwy083C23","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1111\/jgh.13340","article-title":"Acute-on-chronic liver failure in India: The Indian National Association for Study of the Liver consortium experience","volume":"31","author":"Shalimar","year":"2016","journal-title":"J Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t20180831110357_kwy083C24","article-title":"Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure","author":"Wu","journal-title":"Gut"},{"issue":"8","key":"key\n\t\t\t\t20180831110357_kwy083C25","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"2","key":"key\n\t\t\t\t20180831110357_kwy083C26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jhep.2004.10.019","article-title":"Patients with acute on chronic liver failure display \u201csepsis-like\u201d immune paralysis","volume":"42","author":"Wasmuth","year":"2005","journal-title":"J Hepatol"},{"issue":"3","key":"key\n\t\t\t\t20180831110357_kwy083C27","first-page":"1","article-title":"Acute-on-chronic liver failure: recent update","volume":"31","author":"Alam","year":"2017","journal-title":"J Biomed Res"},{"key":"key\n\t\t\t\t20180831110357_kwy083C28","volume-title":"Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection","author":"World Health Organization","year":"2015"},{"issue":"3","key":"key\n\t\t\t\t20180831110357_kwy083C29","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.clinbiochem.2015.10.015","article-title":"Evaluation of bilirubin interference and accuracy of six creatinine assays compared with isotope dilution-liquid chromatography mass spectrometry","volume":"49","author":"Nah","year":"2016","journal-title":"Clin Biochem"},{"issue":"1","key":"key\n\t\t\t\t20180831110357_kwy083C30","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s12291-010-0013-2","article-title":"Modification of Jaffe\u2019s kinetic method decreases bilirubin interference: a preliminary report","volume":"25","author":"Vaishya","year":"2010","journal-title":"Indian J Clin Biochem"},{"issue":"2","key":"key\n\t\t\t\t20180831110357_kwy083C31","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1373\/clinchem.2006.075846","article-title":"Does bilirubin cause interference in Roche creatinine methods?","volume":"53","author":"Owen","year":"2007","journal-title":"Clin Chem"},{"issue":"2","key":"key\n\t\t\t\t20180831110357_kwy083C32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1055\/s-0036-1583199","article-title":"The pathogenesis of ACLF: the inflammatory response and immune function","volume":"36","author":"Moreau","year":"2016","journal-title":"Semin Liver Dis"}],"container-title":["American Journal of Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/aje\/article-pdf\/187\/9\/1829\/25639636\/kwy083.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T00:40:14Z","timestamp":1571013614000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/aje\/article\/187\/9\/1829\/4995331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,14]]},"references-count":32,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,5,14]]},"published-print":{"date-parts":[[2018,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/aje\/kwy083","relation":{},"ISSN":["0002-9262","1476-6256"],"issn-type":[{"value":"0002-9262","type":"print"},{"value":"1476-6256","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,9]]},"published":{"date-parts":[[2018,5,14]]}}}