{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:27:14Z","timestamp":1790720834066,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Geographic variations of invasive pneumococcal disease incidence and serotype distributions were observed after pneumococcal conjugate vaccine introduction at regional levels and among French administrative areas. The variations could be related to regional vaccine coverage (VC) variations that might have direct consequences for vaccination-policy impact on invasive pneumococcal disease, particularly pneumococcal meningitis (PM) incidence. We assessed vaccine impact from 2001 to 2016 in France by estimating the contribution of regional VC differences to variations of annual local PM incidence. Using a mixed-effect Poisson model, we showed that, despite some variations of VC among administrative areas, vaccine impact on vaccine-serotype PM was homogeneously confirmed among administrative areas. Compared with the prevaccine era, the cumulative VC impact on vaccine serotypes led, in 2016, to PM reductions ranging among regions from 87% (25th percentile) to 91% (75th percentile) for 7-valent pneumococcal conjugate vaccine serotypes and from 58% to 63% for the 6 additional 13-valent pneumococcal conjugate vaccine serotypes. Nonvaccine-serotype PM increases from the prevaccine era ranged among areas from 98% to 127%. By taking into account the cumulative impact of growing VC and VC differences, our analyses confirmed high vaccine impact on vaccine-serotype PM case rates and suggest that VC variations cannot explain PM administrative area differences.<\/jats:p>","DOI":"10.1093\/aje\/kwz071","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T20:18:47Z","timestamp":1553113127000},"page":"1466-1474","source":"Crossref","is-referenced-by-count":3,"title":["Association of Pneumococcal Conjugate Vaccine Coverage With Pneumococcal Meningitis: An Analysis of French Administrative Areas, 2001\u20132016"],"prefix":"10.1093","volume":"188","author":[{"given":"Anna","family":"Alari","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche 1181, Universit\u00e9 Versailles St-Quentin-en-Yvelines, Institut Pasteur, Paris, France"},{"name":"Universit\u00e9 Versailles St-Quentin-en-Yvelines, Universit\u00e9 Paris-Saclay, Versailles, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix","family":"Cheysson","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche 1181, Universit\u00e9 Versailles St-Quentin-en-Yvelines, Institut Pasteur, Paris, France"},{"name":"Universit\u00e9 Paris Sud, Universit\u00e9 Paris-Saclay, Le Kremlin Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9naig","family":"Le Fouler","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lanotte","sequence":"additional","affiliation":[{"name":"Observatoires R\u00e9gionaux du Pneumocoque, Service de Bact\u00e9riologie-Virologie-Hygi\u00e8ne Hospitali\u00e8re H\u00f4pital Bretonneau, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Observatoires R\u00e9gionaux du Pneumocoque network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Varon","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence des Pneumocoques, Centre Hospitalier Intercommunal, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulla","family":"Opatowski","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche 1181, Universit\u00e9 Versailles St-Quentin-en-Yvelines, Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Guillemot","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche 1181, 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