{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:05:57Z","timestamp":1792037157638,"version":"4.4.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32CA186873"],"award-info":[{"award-number":["T32CA186873"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infants and children are particularly vulnerable to in utero and early-life exposures. Thus, a mother\u2019s exposures before and during pregnancy could have important consequences for her child\u2019s health, including cancer development. We examined whether birth certificate\u2013derived maternal anthropometric characteristics were associated with increased risk of subsequent childhood cancer development, accounting for established maternal and infant risk factors. Pennsylvania birth and cancer registry files were linked by the state Department of Health, yielding a virtual cohort of births and childhood cancers from 2003 through 2016. The analysis included 1,827,875 infants (13,785,309 person-years at risk), with 2,352 children diagnosed with any cancer and 747 with leukemia before age 14 years. Children born to mothers with a body mass index (weight (kg)\/height (m)2) of \u226540 had a 57% (95% confidence interval: 12, 120) higher leukemia risk. Newborn size of \u226530% higher than expected was associated with 2.2-fold and 1.8-fold hazard ratios for total childhood cancer and leukemia, respectively, relative to those with expected size. Being &lt;30% below expected size also increased the overall cancer risk (P for curvilinearity &lt; 0.0001). Newborn size did not mediate the association between maternal obesity and childhood cancer. The results suggest a significant role of early-life exposure to maternal obesity- and fetal growth\u2013related factors in childhood cancer development.<\/jats:p>","DOI":"10.1093\/aje\/kwz118","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T23:01:17Z","timestamp":1557270077000},"page":"1503-1511","source":"Crossref","is-referenced-by-count":58,"title":["Maternal Obesity, Birth Size, and Risk of Childhood Cancer Development"],"prefix":"10.1093","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3107-9869","authenticated-orcid":false,"given":"Shaina L","family":"Stacy","sequence":"first","affiliation":[{"name":"UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania"},{"name":"Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanine M","family":"Buchanich","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-qiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Bureau of Epidemiology, Pennsylvania Department of Health, Harrisburg, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Mair","sequence":"additional","affiliation":[{"name":"Department of Behavioral and Community Health Sciences, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Robertson","sequence":"additional","affiliation":[{"name":"UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania"},{"name":"Department of Medicine, University of Pittsburgh, Pittsburgh, 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