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Using a cohort of 1,780,156 pregnant women and their offspring nested in the 2000\u20132013 US Medicaid Analytic eXtract, we contrasted time trends in malformations which do not necessarily present with overt clinical symptoms early in life and are more likely to be diagnosed via imaging (secundum atrial septal defect, patent ductus arteriosus, ventricular septal defect, pulmonary artery anomalies, pulmonary valve stenosis, hydrocephalus) with trends in malformations that are unlikely to escape clinical diagnosis (tetralogy of Fallot, coarctation of the aorta, transposition of the great vessels, hypoplastic left heart syndrome, oral cleft, abdominal wall defect). Logistic regression was used to account for trends in risk factors while assessing the impact of increased screening intensity. Prevalence of the diagnosis of secundum atrial septal defect rose from 2.3\u2030 in 2000\u20132001 to 7.5\u2030 in 2012\u20132013, of patent ductus arteriosus from 1.9\u2030 to 4.1\u2030, and of ventricular septal defect from 3.6\u2030 to 4.5\u2030. Trends were not explained by changes in the prevalence of risk factors but were attenuated when accounting for screening tests. The other malformations showed no temporal trends. Findings suggest that increased screening partially explains the observed increase in diagnosis of milder cases of select common malformations.<\/jats:p>","DOI":"10.1093\/aje\/kwz153","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T15:13:52Z","timestamp":1560870832000},"page":"1892-1901","source":"Crossref","is-referenced-by-count":10,"title":["The Impact of Technology on the Diagnosis of Congenital Malformations"],"prefix":"10.1093","volume":"188","author":[{"given":"Loreen","family":"Straub","sequence":"first","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krista F","family":"Huybrechts","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian T","family":"Bateman","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts"},{"name":"Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Mogun","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn J","family":"Gray","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women\u2019s Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis B","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Pediatric Newborn Medicine, Brigham and Women\u2019s Hospital, Boston, Massachusetts"},{"name":"Medical Genetics Unit, MassGeneral Hospital for Children, Boston, Massachusetts"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Hernandez-Diaz","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. 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