{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:10:57Z","timestamp":1792793457736,"version":"4.5.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T00:00:00Z","timestamp":1585872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400289"],"award-info":[{"award-number":["81400289"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970262"],"award-info":[{"award-number":["81970262"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program of Sichuan Youth Science and Technology Foundation in China","award":["2016JQ0032"],"award-info":[{"award-number":["2016JQ0032"]}],"id":[{"id":"https:\/\/ror.org\/00xs3qr03","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004884","name":"Education Department of Sichuan Province","doi-asserted-by":"publisher","award":["18TD0030"],"award-info":[{"award-number":["18TD0030"]}],"id":[{"id":"10.13039\/501100004884","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Project of Education Department in Sichuan Province","award":["16ZA0293"],"award-info":[{"award-number":["16ZA0293"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Oxidative stress is known to be associated with the development of diabetes. Cinnamaldehyde (CA) is a spice compound in cinnamon that enhances the antioxidant defense against reactive oxygen species (ROS) by activating nuclear factor erythroid-related factor 2 (Nrf2), which has been shown to have a cardioprotection effect. However, the relationship between CA and Nrf2 in diabetic vascular complications remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Leptin receptor-deficient (db\/db) mice were fed normal chow or diet containing 0.02% CA for 12 weeks. The vascular tone, blood pressure, superoxide level, nitric oxide (NO) production, renal morphology, and function were measured in each group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>CA remarkably inhibited ROS generation, preserved NO production, increased phosphorylated endothelial nitric oxide synthase (p-eNOS), attenuated the upregulation of nitrotyrosine, P22 and P47 in aortas of db\/db mice, and apparently ameliorated the elevation of type IV collagen, TGF-\u03b21, P22, and P47 in kidney of db\/db mice. Feeding with CA improved endothelium-dependent relaxation of aortas and mesenteric arteries, and alleviated the remodeling of mesenteric arteries in db\/db mice. Additionally, dietary CA ameliorated glomerular fibrosis and renal dysfunction in diabetic mice. Nrf2 and its targeted genes heme oxygenase-1 (HO-1) and quinone oxidoreductase-1 (NQO-1) were slightly increased in db\/db mice and further upregulated by CA. However, these protective effects of CA were reversed in Nrf2 downregulation mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>A prolonged diet of CA protects against diabetic vascular dysfunction by inhibiting oxidative stress through activating of Nrf2 signaling pathway in db\/db mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajh\/hpaa024","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T07:17:38Z","timestamp":1585725458000},"page":"610-619","source":"Crossref","is-referenced-by-count":48,"title":["Cinnamaldehyde Ameliorates Vascular Dysfunction in Diabetic Mice by Activating Nrf2"],"prefix":"10.1093","volume":"33","author":[{"given":"Peijian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, The General Hospital of Western Theater Command , Chengdu, PR China"},{"name":"Department 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