{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:24:55Z","timestamp":1792697095029,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:00:00Z","timestamp":1585180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1030297"],"award-info":[{"award-number":["GNT1030297"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Hypertension is a common comorbidity associated with chronic kidney disease (CKD). Treatment in these patients often involves L-type Ca2+ channel (LTCC) blockers. The effect of chronic LTCC-blockade treatment on resistance vasculature was investigated in a genetic hypertensive rat model of CKD, the Lewis Polycystic Kidney (LPK) rat.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Mixed-sex LPK and Lewis control rats (total n = 38) were allocated to treated (amlodipine 20 mg\/kg\/day p.o. from 4 to 18 weeks) and vehicle groups. Following systolic blood pressure and renal function assessment, animals were euthanized and mesenteric vasculature was collected for functional and structural assessment using pressure myography and histology.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Amlodipine treatment reduced LPK rat blood pressure (untreated vs. treated: 185 \u00b1 5 vs. 165 \u00b1 9 mm Hg; P = 0.019), reduced plasma creatinine (untreated vs. treated: 197 \u00b1 17 vs. 140 \u00b1 16 \u00b5mol\/l; P = 0.002), and improved some vascular structural parameters (internal and external diameters and wall\u2013lumen ratios); however wall thickness was still increased in LPK relative to Lewis despite treatment (Lewis vs. LPK: 31 \u00b1 2 vs. 41 \u00b1 2 \u00b5m, P = 0.047). Treatment improved LPK rats\u2019 endothelium dysfunction, and nitric oxide-dependent and endothelium-derived hyperpolarization vasorelaxation components, and downregulated prostanoid contributions. LTCC blockade had no effect on biomechanical properties of compliance and intrinsic stiffness, nor artery wall composition.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Our results indicate that blockade of LTCCs with amlodipine is effective in improving, to a certain extent, detrimental structural and functional vascular features of resistance arteries in CKD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpaa054","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T12:07:48Z","timestamp":1585051668000},"page":"634-643","source":"Crossref","is-referenced-by-count":6,"title":["Amlodipine Improves Vessel Function and Remodeling in the Lewis Polycystic Kidney Rat Mesenteric Artery"],"prefix":"10.1093","volume":"33","author":[{"given":"Ko Jin","family":"Quek","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, 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