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We aimed to assess if also self-reported hypertension onset age is associated with hypertension-mediated organ damage (HMOD). Additionally, we evaluated the agreement between self-reported and objectively defined hypertension onset age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We studied 2,649 participants (50 \u00b1 4 years at the time of outcome assessment, 57% women) of the Coronary Artery Risk Development in Young Adults (CARDIA) study who underwent measurements for echocardiographic left ventricular hypertrophy (LVH), left ventricular diastolic dysfunction (LVDD), coronary calcification, and albuminuria. We divided the participants into groups according to self-reported hypertension onset age (&amp;lt;35 years, 35\u201344 years, \u226545 years, and no hypertension). We used multivariable-adjusted logistic regression models to assess the relation between self-reported hypertension onset age with the presence of HMOD, with those who did not report hypertension as the referent group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Compared with individuals without self-reported hypertension, self-reported hypertension onset at &amp;lt;35 years was associated with LVH (odds ratio (OR), 2.38; 95% confidence interval (CI), 1.51\u20133.76), LVDD (OR, 2.32; 95% CI, 1.28\u20134.18, coronary calcification (OR, 2.87; 95% CI, 1.50\u20135.47), and albuminuria (OR, 1.62; 95% CI, 0.81\u20133.26). Self-reported hypertension onset at \u226545 years was only associated with LVDD (OR, 1.81; 95% CI, 1.06\u20133.08). The agreement between self-reported and objectively defined hypertension onset age groups was 78\u201379%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our findings suggest that self-reported hypertension onset age, a pragmatically feasible assessment in clinical practice, is a reasonable method for assessing risk of HMOD and CVD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpaa055","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T20:12:43Z","timestamp":1585253563000},"page":"644-651","source":"Crossref","is-referenced-by-count":23,"title":["Self-reported Age of Hypertension Onset and Hypertension-Mediated Organ Damage in Middle-Aged Individuals"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3543-9350","authenticated-orcid":false,"given":"Karri","family":"Suvila","sequence":"first","affiliation":[{"name":"Division of Medicine, Turku University Hospital and University of Turku , Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L","family":"McCabe","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women\u2019s Hospital , Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao A C","family":"Lima","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University , Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenni","family":"Aittokallio","sequence":"additional","affiliation":[{"name":"Division of Perioperative Services, Turku University Hospital and University of Turku , Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Community Health, Duke University , Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women\u2019s Hospital , Boston, Massachusetts, USA"},{"name":"Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center , Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teemu J","family":"Niiranen","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women\u2019s Hospital , Boston, Massachusetts, USA"},{"name":"Department of Public Health Solutions, Finnish Institute for Health 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