{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:34:29Z","timestamp":1777898069319,"version":"3.51.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG44170"],"award-info":[{"award-number":["AG44170"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG034676"],"award-info":[{"award-number":["AG034676"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL118154"],"award-info":[{"award-number":["HL118154"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL007936"],"award-info":[{"award-number":["HL007936"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000135"],"award-info":[{"award-number":["UL1 TR000135"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007048","name":"Mayo Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Studies demonstrate an association between aortic hemodynamics and cognitive function. The impact of pregnancy history on this association is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Postmenopausal women (age 59 \u00b1 5 years; years since last pregnancy 35 \u00b1 3) with either a history of preeclampsia (PE; n = 34) or a history of a normotensive pregnancy (NP; n = 30) underwent cognitive testing: Letter-Number Sequencing, Digit Span, Trail Making Test, and letter and category fluency. Applanation tonometry was used to derive aortic systolic and diastolic blood pressure and augmentation index.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Distribution of cognitive scores and aortic hemodynamic measures was similar between the PE and NP groups. Principal component (PC) analysis was used to reduce the 3 aortic hemodynamic measures and the 5 cognitive variables to single summary indices, each representing a weighted average of their respective constituent variables. Using a multivariable linear model based on these PCs that adjusted for pregnancy history and body mass index, the composite index of aortic hemodynamics was associated with the summary cognitive index, whether taking into account a potential interaction with pregnancy history (P = 0.035) or not (P = 0.026) (interaction P = 0.178). Multivariable modeling of individual cognitive tests revealed a differential association for letter fluency by pregnancy history (test for interaction P = 0.023); this score correlated with the aortic hemodynamic index in the PE (partial R2 = 0.20), but not the NP (partial R2 = 0.00) group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Elevated aortic hemodynamics may negatively impact cognitive function in postmenopausal women with specific executive functions, such as letter fluency, being impacted more by a pregnancy history of PE.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpaa081","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T19:09:23Z","timestamp":1589310563000},"page":"756-764","source":"Crossref","is-referenced-by-count":11,"title":["Aortic Hemodynamics and Cognitive Performance in Postmenopausal Women: Impact of Pregnancy History"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2878-3978","authenticated-orcid":false,"given":"Kathleen B","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Kinesiology, University of Wisconsin-Madison , Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A","family":"Fields","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, Mayo Clinic , Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron\u00e9e E","family":"Harvey","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Minnesota Medical School , Minneapolis, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian D","family":"Lahr","sequence":"additional","affiliation":[{"name":"Department of Health Science Research, Mayo Clinic , Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent R","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Health Science Research, Mayo Clinic , Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J","family":"Joyner","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Mayo Clinic , Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia M","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota, USA"},{"name":"Department of Surgery, Mayo Clinic , Rochester, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill N","family":"Barnes","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Wisconsin-Madison , Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,5,18]]},"reference":[{"key":"2024020716051238600_CIT0001","doi-asserted-by":"crossref","first-page":"E29","DOI":"10.1111\/chf.12025","article-title":"Cerebral perfusion is associated with white matter hyperintensities in older adults with heart failure","volume":"19","author":"Alosco","year":"2013","journal-title":"Congest Heart Fail"},{"key":"2024020716051238600_CIT0002","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/bmj.39335.385301.BE","article-title":"Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis","volume":"335","author":"Bellamy","year":"2007","journal-title":"BMJ"},{"key":"2024020716051238600_CIT0003","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1097\/HJH.0b013e328335c29a","article-title":"Hypertension in pregnancy as a risk factor for cardiovascular disease later in life","volume":"28","author":"Garovic","year":"2010","journal-title":"J Hypertens"},{"key":"2024020716051238600_CIT0004","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1177\/1933719113518989","article-title":"Long-term risk to develop hypertension in women with former preeclampsia","volume":"21","author":"Ghossein-Doha","year":"2014","journal-title":"Reprod Sci"},{"key":"2024020716051238600_CIT0005","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1136\/bmj.323.7323.1213","article-title":"Long term mortality of mothers and fathers after pre-eclampsia: population based cohort study. 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