{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:17:19Z","timestamp":1788833839728,"version":"build-2803163510"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Japan Health Promotion Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Our aims were to assess whether arterial stiffness is associated with a higher risk for kidney dysfunction among persons without chronic kidney disease (CKD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We analyzed data from the national health checkup system in Japan; for our analyses, we selected records of individuals who completed assessments of cardio-ankle vascular index (CAVI) and kidney function from 2005 to 2016. We excluded participants who had CKD at baseline, defined as the presence of proteinuria or estimated glomerular filtration rate (eGFR) &amp;lt;60 ml\/min\/1.73 m2. We compared 2 groups of CAVI measurements\u2014the highest quartile (\u22678.1) and the combined lower 3 quartiles (&amp;lt;8.1). We used Cox proportional hazards models to assess associations between these 2 groups and subsequent CKD events, proteinuria, eGFR &amp;lt;60 ml\/min\/1.73 m2, and rapid eGFR decline (greater than or equal to \u22123 ml\/min\/1.73 m2 per year).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The mean age of the 24,297 included participants was 46.2 years, and 60% were female. Over a mean follow-up of 3.1 years, 1,435 CKD events occurred. In a multivariable analysis, the hazard ratios with 95% confidence intervals (CIs) for the highest vs. combined lower quartiles of CAVI measurements were 1.3 (1.1, 1.5) for CKD events, 1.3 (0.96, 1.62) for proteinuria, 1.4 (1.1, 1.7) for eGFR &amp;lt;60 ml\/min\/1.73 m2, and the odds ratio with 95% CI was 1.3 (1.1, 1.4) for rapid eGFR decline.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Persons with CAVI measurements \u22678.1 had a higher risk for CKD events compared with their counterparts with CAVI measurements &amp;lt;8.1. Greater arterial stiffness among adults without CKD may be associated with kidney dysfunction.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpaa097","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T11:29:06Z","timestamp":1591788546000},"page":"1003-1010","source":"Crossref","is-referenced-by-count":19,"title":["Association of Arterial Stiffness With Kidney Function Among Adults Without Chronic Kidney Disease"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9452-4117","authenticated-orcid":false,"given":"Seiji","family":"Itano","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension, Kawasaki Medical School , Kurashiki, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Community Health, Duke University , Durham, North Carolina, 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Kurashiki, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Kawasaki Medical School , Kurashiki, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Japan Health Promotion Foundation , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond R","family":"Townsend","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Budoff","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center , Torrance, CA, 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