{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:54:14Z","timestamp":1790610854553,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Malignant hypertension is macrovascular and microvascular endothelial injury responsible for multiple organ damage. Considering the anatomical and functional homologies between the posterior pole of the eye and the kidney, ophthalmological explorations may inform clinicians on the mechanisms underpinning concurrent kidney injury in this condition. More specifically, we investigated whether the wall-to-lumen ratio (WLR) of retinal arterioles measured by adaptive optics ophthalmoscopy could be correlated to WLR of kidney arterioles as determined by pathology. We sought to estimate the incidence of retinal arteriole occlusion a supposedly uncommon complication of malignant hypertension.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>All patients hospitalized in our renal Intensive Care Unit for malignant hypertension between 2016 and 2019 were referred to ophthalmological examinations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Twenty-seven patients were included. Median retinal WLR was 0.39 [0.31\u20130.47] and was correlated with initial systolic (r = 0.56, P = 0.003) and mean blood pressure (r = 0.46, P = 0.02) upon admission. The retinal WLR was not correlated to renal pathological findings, as assessed by juxtaglomerular WLR (r = 0.38, P = 0.2), ratio of glomerulosclerosis (r = \u22120.39, P = 0.2), or tubulointerstitial fibrosis (r = \u22120.45, P = 0.08). Retinal WLR was not associated with neurological or cardiovascular end-organ damage. Branch retinal artery occlusion was detected in 18.5% of patients and exudative retinal detachment (ERD) in 29.6% of patients, without any significant correlation with canonical signs of retinal hypertension including optic disc swelling.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>In the setting of malignant hypertension, we failed to demonstrate a significant relationship between WLR and other meaningful end-organ injuries. However, branch retinal artery occlusion and ERD may have been hitherto underestimated.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpaa138","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T11:22:12Z","timestamp":1597836132000},"page":"30-33","source":"Crossref","is-referenced-by-count":8,"title":["Retinal Arteriolar Occlusions and Exudative Retinal Detachments in Malignant Hypertension: More Than Meets the Eye"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3714-8768","authenticated-orcid":false,"given":"Tristan","family":"de Nattes","sequence":"first","affiliation":[{"name":"Urgences N\u00e9phrologiques et Transplantation R\u00e9nale, H\u00f4pital Tenon, Assistance Publique H\u00f4pitaux de Paris, Sorbonne Universit\u00e9 , Paris, France"},{"name":"Nephrology\u2014Kidney Transplant Unit, Rouen University Hospital , Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, PARIS Group, Quinze-Vingts Hospital , Paris, France"},{"name":"Institut hospitalo-universitaire FOReSIGHT, H\u00f4pital des Quinze-Vingts , Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Buob","sequence":"additional","affiliation":[{"name":"Pathology Department, H\u00f4pital Tenon, Assistance Publique H\u00f4pitaux de Paris, Sorbonne Universit\u00e9 , Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Verney","sequence":"additional","affiliation":[{"name":"Urgences N\u00e9phrologiques et Transplantation R\u00e9nale, H\u00f4pital Tenon, Assistance Publique H\u00f4pitaux de Paris, Sorbonne Universit\u00e9 , Paris, 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