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Orthostatic hypotension (OH) measured using both seated (or supine) and standing BP, could identify phenotypes poorly captured by seated clinic BP alone.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We examined the association of OH with WCE and night-to-daytime systolic BP (SBP) in a subpopulation of SPRINT, a randomized trial testing the effects of intensive or standard (&amp;lt;120 vs. &amp;lt;140 mm Hg) SBP treatment strategies in adults at increased risk of cardiovascular disease. OH was assessed during follow-up (6, 12, and 24 months) and defined as a decrease in mean seated SBP \u226520 or diastolic BP \u226510 mm Hg after 1 min of standing. WCE, based on 24-hour ambulatory BP monitoring performed at 27 months, was defined as the difference between 27-month seated clinic and daytime ambulatory BP \u226520\/\u226510 mm Hg. Reverse dipping was defined as a ratio of night-to-daytime SBP &amp;gt;1.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 897 adults (mean age 71.5\u00b19.5 years, 29% female, 28% black), 128 had OH at least once. Among those with OH, 15% had WCE (vs. 7% without OH). Moreover, 25% of those with OH demonstrated a non-dipping pattern (vs. 14% without OH). OH was positively associated with both WCE (OR=2.24; 95%CI: 1.28, 4.27) and reverse dipping (OR=2.29; 95% CI: 1.31, 3.99).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The identification of OH in clinic was associated with two BP phenotypes often missed with traditional seated BP assessments. Further studies on mechanisms of these relationships are needed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical trials registration<\/jats:title>\n                  <jats:p>Trial Number NCT03569020.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpaa184","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T20:12:22Z","timestamp":1604693542000},"page":"511-520","source":"Crossref","is-referenced-by-count":13,"title":["The Association of Orthostatic Hypotension With Ambulatory Blood Pressure Phenotypes in SPRINT"],"prefix":"10.1093","volume":"34","author":[{"given":"Lama","family":"Ghazi","sequence":"first","affiliation":[{"name":"Yale University, School of Medicine, Clinical and Translational Research Accelerator , New Haven, Connecticut , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E","family":"Drawz","sequence":"additional","affiliation":[{"name":"University of Minnesota Medical School, Department of Medicine, Division of Nephrology and Hypertension , Minneapolis, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M","family":"Pajewski","sequence":"additional","affiliation":[{"name":"Wake Forest School of Medicine, Department of Biostatistics and Data Science , Winston-Salem, North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4168-2696","authenticated-orcid":false,"given":"Stephen P","family":"Juraschek","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Harvard Medical School, Department of Medicine, Division of General Medicine , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,22]]},"reference":[{"key":"2022101009223985900_CIT0001","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jacc.2017.10.073","article-title":"Potential U.S. population impact of the 2017 ACC\/AHA High Blood Pressure Guideline","volume":"71","author":"Muntner","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2022101009223985900_CIT0002","first-page":"e13","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"71","author":"Whelton","year":"2018","journal-title":"Hypertension"},{"key":"2022101009223985900_CIT0003","doi-asserted-by":"crossref","first-page":"e011706","DOI":"10.1161\/JAHA.118.011706","article-title":"Effect of intensive and standard clinic-based hypertension management on the concordance between clinic and ambulatory blood pressure and blood pressure variability in SPRINT","volume":"8","author":"Ghazi","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2022101009223985900_CIT0004","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1056\/NEJMoa1511939","article-title":"A randomized trial of intensive versus standard blood-pressure control","volume":"373","author":"Wright","year":"2015","journal-title":"N Engl J Med"},{"key":"2022101009223985900_CIT0005","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF02291236","article-title":"Consensus statement on the definition of orthostatic hypotension, pure autonomic failure and multiple system atrophy","volume":"6","author":"Kaufmann","year":"1996","journal-title":"Clin Auton Res"},{"key":"2022101009223985900_CIT0006","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10286-011-0119-5","article-title":"Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome","volume":"21","author":"Freeman","year":"2011","journal-title":"Clin Auton Res"},{"key":"2022101009223985900_CIT0007","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1161\/01.HYP.19.6.508","article-title":"Orthostatic hypotension in older adults. 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