{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:48:02Z","timestamp":1757310482320,"version":"3.37.3"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,5,23]],"date-time":"2021-05-23T00:00:00Z","timestamp":1621728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013642","name":"Japan Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013642","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Japanese Society of Cardiovascular Disease Prevention"},{"name":"AstraZeneca K.K."},{"DOI":"10.13039\/100016274","name":"Omron Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>To evaluate the effectiveness of the nurse-led alcohol guidance to control home blood pressure (HBP) in the morning among male patients with hypertension during outpatient visits.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We enrolled 53 male patients with an HBP of \u2265135\/85 mm Hg with excessive drinking (alcohol \u2265210 g\/week or \u226560 g\/day habitually) among outpatients in a randomized trial. Patients were assigned to a nurse-led alcohol guidance intervention or to the control. The primary outcomes were the mean HBP of 5 consecutive days at 6 months and alcohol consumption.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty-eight and 25 patients were randomized to intervention and control groups, respectively (mean age; 62.7 years old and 64.5, respectively). At baseline, the groups were well balanced across most characteristics. At 6 months, the mean HBP was 131\/82 mm Hg in the intervention group vs. 145\/87 mm Hg in the control group (SBP &amp;lt;0.001, DBP = 0.09). An HBP level of less than 135\/85 mm Hg was achieved among 55.6% of the participants in the intervention group vs. 16.7% in the control group (P = 0.004). The alcohol consumption at 6 months was 256 \u00b1 206 g\/w vs. 413 \u00b1 260 g\/w, respectively (P = 0.020).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We confirmed the effectiveness of the nurse-led alcohol guidance to control the HBP in male patients with hypertension during outpatient visits.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Public trials registry number<\/jats:title>\n                  <jats:p>UMIN000017454 (UMIN Clinical Trials Registry).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpab082","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T19:20:05Z","timestamp":1621452005000},"page":"1108-1115","source":"Crossref","is-referenced-by-count":8,"title":["A Randomized Trial of Home Blood-Pressure Reduction by Alcohol Guidance During Outpatient Visits: OSAKE Study"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1394-1152","authenticated-orcid":false,"given":"Mai","family":"Kabayama","sequence":"first","affiliation":[{"name":"Department of Health Sciences, Osaka University Graduate School of Medicine , Suita , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Akagi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Osaka University Graduate School of Medicine , Suita , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Osaka University Graduate School of Medicine , Suita , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Osaka University Graduate School of Medicine , Suita , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Tamatani","sequence":"additional","affiliation":[{"name":"Tamatani Clinic , Osaka, Osaka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Tomita","sequence":"additional","affiliation":[{"name":"Toyonaka Watanabe Clinic , Toyonaka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukako","family":"Nakata","sequence":"additional","affiliation":[{"name":"Toyonaka Watanabe Clinic , Toyonaka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Takiuchi","sequence":"additional","affiliation":[{"name":"Higashi Takarazuka Satoh Hospital , Takarazuka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine , Suita , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine , Suita , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Shintani","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Osaka City University Graduate School of Medicine and Faculty of Medicine , Osaka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Rakugi","sequence":"additional","affiliation":[{"name":"Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine , Suita , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Kamide","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Osaka University Graduate School of Medicine , Suita , 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