{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:11:48Z","timestamp":1785870708915,"version":"3.56.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,2]]},"DOI":"10.1093\/ajh\/hpab194","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T12:15:52Z","timestamp":1640002552000},"page":"303-305","source":"Crossref","is-referenced-by-count":13,"title":["New Evidence for Homocysteine Lowering for Management of Treatment-Resistant Hypertension"],"prefix":"10.1093","volume":"35","author":[{"given":"Merrill F","family":"Elias","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Maine and Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig J","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, College of Medicine, University of Arkansas for Medical Sciences, Fayetteville, Arkansas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"2022040205405691100_CIT0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ajh\/hpy156","article-title":"Resistant hypertension: an update","volume":"32","author":"Calhoun","year":"2019","journal-title":"Am J Hypertens"},{"key":"2022040205405691100_CIT0002","doi-asserted-by":"crossref","first-page":"173","DOI":"10.17219\/acem\/58998","article-title":"Resistant hypertension","volume":"25","author":"Doroszko","year":"2016","journal-title":"Adv Clin Exp Med"},{"key":"2022040205405691100_CIT0003","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mam.2016.10.002","article-title":"Riboflavin, MTHFR genotype and blood pressure: a personalized approach to prevention and treatment of hypertension","volume":"53","author":"McNulty","year":"2017","journal-title":"Mol Aspects Med"},{"key":"2022040205405691100_CIT0004","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1161\/HYPERTENSIONAHA.111.01047","article-title":"Blood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trial","volume":"61","author":"Wilson","year":"2013","journal-title":"Hypertension"},{"key":"2022040205405691100_CIT0005","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11906-003-0007-z","article-title":"Homocysteine and blood pressure","volume":"5","author":"van Guldener","year":"2003","journal-title":"Curr Hypertens Rep"},{"key":"2022040205405691100_CIT0006","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/joim.13279","article-title":"Homocysteine\u2014from disease biomarker to disease prevention","volume":"290","author":"Smith","year":"2021","journal-title":"J Intern Med"},{"key":"2022040205405691100_CIT0007","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1161\/01.HYP.0000101690.58391.13","article-title":"Plasma homocysteine, hypertension incidence, and blood pressure tracking: the Framingham Heart Study","volume":"42","author":"Sundstr\u00f6m","year":"2003","journal-title":"Hypertension"},{"key":"2022040205405691100_CIT0008","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJMoa060900","article-title":"Homocysteine lowering with folic acid and B vitamins in vascular disease","volume":"354","author":"Lonn","year":"2006","journal-title":"N Engl J Med"},{"key":"2022040205405691100_CIT0009","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1056\/NEJMoa055227","article-title":"Homocysteine lowering and cardiovascular events after acute myocardial infarction","volume":"354","author":"B\u00f8naa","year":"2006","journal-title":"N Engl J Med"},{"key":"2022040205405691100_CIT0010","author":"Brookes","year":"2005"},{"key":"2022040205405691100_CIT0011","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1161\/01.STR.0000199621.28234.e2","article-title":"Homocysteine: call off the funeral","volume":"37","author":"Spence","year":"2006","journal-title":"Stroke"},{"key":"2022040205405691100_CIT0012","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1080\/10641963.2016.1226888","article-title":"Homocysteine levels and risk of essential hypertension: a meta-analysis of published epidemiological studies","volume":"39","author":"Zhong","year":"2017","journal-title":"Clin Exp Hypertens"},{"key":"2022040205405691100_CIT0013","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1515\/jtim-2015-0027","article-title":"H-type hypertension and risk of stroke in Chinese adults: a prospective, nested case-control study","volume":"3","author":"Li","year":"2015","journal-title":"J Transl Int Med"},{"key":"2022040205405691100_CIT0014","doi-asserted-by":"crossref","first-page":"e21953","DOI":"10.1097\/MD.0000000000021953","article-title":"Evaluation of H-type hypertension prevalence and its influence on the risk of increased carotid intima-media thickness among a high-risk stroke population in Hainan Province, China","volume":"99","author":"Zhou","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"2022040205405691100_CIT0015","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/jhh.2015.17","article-title":"Interactions between plasma homocysteine and arterial stiffness in chronic kidney disease in community-dwelling individuals: the Maine-Syracuse Study","volume":"29","author":"Elias","year":"2015","journal-title":"J Hum Hypertens"},{"key":"2022040205405691100_CIT0016","article-title":"The interaction of hypertension and homocysteine increases the risk of mortality among middle-aged and older population in the United States","author":"Zhao","year":"2021","journal-title":"J Hypertens"},{"key":"2022040205405691100_CIT0017","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1038\/s41598-017-05205-3","article-title":"Association between homocysteine levels and all-cause mortality: a dose-response meta-analysis of prospective studies","volume":"7","author":"Fan","year":"2017","journal-title":"Sci Rep"},{"key":"2022040205405691100_CIT0018","doi-asserted-by":"crossref","first-page":"190","DOI":"10.7326\/M19-0341","article-title":"Effects of nutritional supplements and dietary interventions on cardiovascular outcomes: an umbrella review and evidence map","volume":"171","author":"Khan","year":"2019","journal-title":"Ann Intern Med"},{"key":"2022040205405691100_CIT0019","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1017\/S0029665119000661","article-title":"Addressing optimal folate and related B-vitamin status through the lifecycle: health impacts and challenges","volume":"78","author":"McNulty","year":"2019","journal-title":"Proc Nutr Soc"},{"key":"2022040205405691100_CIT0020","doi-asserted-by":"crossref","first-page":"535","DOI":"10.2165\/11532990-000000000-00000","article-title":"Folic acid and","volume":"49","author":"Pietrzik","year":"2010","journal-title":"Clin Pharmacokinet"},{"key":"2022040205405691100_CIT0021","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.copbio.2017.01.006","article-title":"Folate nutrition and blood-brain barrier dysfunction","volume":"44","author":"Stover","year":"2017","journal-title":"Curr Opin Biotechnol"}],"container-title":["American Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajh\/advance-article-pdf\/doi\/10.1093\/ajh\/hpab194\/42018664\/hpab194.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/35\/4\/303\/43231224\/hpab194.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/35\/4\/303\/43231224\/hpab194.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T05:41:20Z","timestamp":1648878080000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajh\/article\/35\/4\/303\/6475983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,22]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,12,22]]},"published-print":{"date-parts":[[2022,4,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ajh\/hpab194","relation":{},"ISSN":["0895-7061","1941-7225"],"issn-type":[{"value":"0895-7061","type":"print"},{"value":"1941-7225","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,4,1]]},"published":{"date-parts":[[2021,12,22]]}}}