{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:38:09Z","timestamp":1780479489265,"version":"3.54.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1G1A1099753"],"award-info":[{"award-number":["2019R1G1A1099753"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The relationship between orthostatic blood pressure (BP) changes and incident chronic kidney disease (CKD) has not been explored in Asian populations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We reviewed the data of 7,039 participants from the Ansung-Ansan cohort study. BP was measured in the supine position and 2 minutes after standing. The change in BP from the supine to upright position was defined as orthostatic BP change. Orthostatic systolic BP (SBP) decline was defined as an orthostatic SBP change of &amp;lt;\u22122 mm Hg. The primary outcome was the development of CKD, defined as the first event of an estimated glomerular filtration rate &amp;lt;60 ml\/min\/1.73 m2 at least twice during the follow-up period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 7,039 participants, 949 (13.5 %) developed incident CKD over a mean of 11.9 years. Although orthostatic diastolic BP change was not associated with incident CKD, every 1 mm Hg increase in orthostatic SBP change was associated with a decreased risk of incident CKD (HR, 0.989; 95% CI, 0.982\u20130.995; P = 0.001). Orthostatic SBP decline was associated with an increased risk of incident CKD (HR, 1.337; 95% CI, 1.163\u20131.537; P &amp;lt; 0.001). Older age and diabetes were associated with increased odds of orthostatic SBP decline, whereas male sex and high body mass index were associated with decreased odds of orthostatic SBP decline. Subgroup analysis revealed that orthostatic SBP decline was associated with incident CKD only in non-diabetic participants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Orthostatic SBP decline was independently associated with an increased risk of future incident CKD, whereas orthostatic DBP decline was not.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpac041","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T04:17:09Z","timestamp":1648181829000},"page":"656-663","source":"Crossref","is-referenced-by-count":3,"title":["Risk of Chronic Kidney Disease Associated With Orthostatic Hypotensive Stress: A Community-Based Korean Study"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9654-8879","authenticated-orcid":false,"given":"Hyun-Lee","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Uijeongbu Eulji Medical Center, Eulji University , Gyeonggi-do , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyang-Ki","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nowon Eulji Medical Center, Eulji University , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Uijeongbu Eulji Medical Center, Eulji University , Gyeonggi-do , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"2022070115161079000_CIT0001","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.autneu.2011.02.004","article-title":"Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome","volume":"161","author":"Freeman","year":"2011","journal-title":"Auton Neurosci: Basic Clin"},{"key":"2022070115161079000_CIT0002","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ajh.2010.146","article-title":"Morbidity and mortality of orthostatic hypotension: implications for management of cardiovascular disease","volume":"24","author":"Benvenuto","year":"2011","journal-title":"Am J Hypertens"},{"key":"2022070115161079000_CIT0003","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/gerona\/gly188","article-title":"The prevalence of orthostatic hypotension: a systematic review and meta-analysis","volume":"75","author":"Saedon","year":"2020","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2022070115161079000_CIT0004","doi-asserted-by":"crossref","first-page":"e8004","DOI":"10.1097\/MD.0000000000008004","article-title":"Prevalence, risk factors, and prognosis of orthostatic hypotension in diabetic patients: a systematic review and meta-analysis","volume":"96","author":"Zhou","year":"2017","journal-title":"Medicine"},{"key":"2022070115161079000_CIT0005","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/eurheartj\/ehp329","article-title":"Orthostatic hypotension predicts all-cause mortality and coronary events in middle-aged individuals (The Malmo Preventive Project)","volume":"31","author":"Fedorowski","year":"2010","journal-title":"Eur Heart J"},{"key":"2022070115161079000_CIT0006","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.jacc.2018.05.079","article-title":"Orthostatic hypotension: JACC state-of-the-art review","volume":"72","author":"Freeman","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2022070115161079000_CIT0007","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/jch.13521","article-title":"Orthostatic hypotension: from pathophysiology to clinical applications and therapeutic considerations","volume":"21","author":"Magkas","year":"2019","journal-title":"J Clin Hypertens"},{"key":"2022070115161079000_CIT0008","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1161\/HYPERTENSIONAHA.110.156380","article-title":"Orthostatic hypotension and incident chronic kidney disease: the atherosclerosis risk in communities study","volume":"56","author":"Franceschini","year":"2010","journal-title":"Hypertension"},{"key":"2022070115161079000_CIT0009","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1093\/ije\/dyv316","article-title":"Cohort profile: The Korean Genome and Epidemiology Study (KoGES) Consortium","volume":"46","author":"Kim","year":"2017","journal-title":"Int J Epidemiol"},{"key":"2022070115161079000_CIT0010","first-page":"151","article-title":"World Health Organization International Society of Hypertension Guidelines for the Management of Hypertension. 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