{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:55:25Z","timestamp":1791809725356,"version":"4.3.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare, Japan","doi-asserted-by":"publisher","award":["21AA2007"],"award-info":[{"award-number":["21AA2007"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["20H03907"],"award-info":[{"award-number":["20H03907"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["21H03159"],"award-info":[{"award-number":["21H03159"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["21K08123"],"award-info":[{"award-number":["21K08123"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Results of preceding studies on the relationship between blood pressure (BP) and cancers have been confounded due to individuals taking antihypertensive medications or shared risk factors. We assessed whether medication-na\u00efve high BP is a risk factor for incident cancers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>This retrospective observational study included 1,388,331 individuals without a prior history of cancer and not taking antihypertensive medications enrolled in the JMDC Claims Database between 2005 and 2018. The primary outcome was 16 cancers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The median [interquartile range] age was 45 [40\u201352] years and 56.2% were men. Mean systolic BP (SBP) and diastolic BP (DBP) were 117.7 \u00b1 15.8 and 72.8 \u00b1 11.6 mm Hg. Multivariate Cox regression analysis demonstrated that SBP per 1-SD was associated with a higher incidence of thyroid (hazard ratio [HR]: 1.09, 95% confidence interval [CI]: 1.03\u20131.16), esophageal (HR: 1.15, 95% CI: 1.07\u20131.24), colorectal (HR: 1.04, 95% CI: 1.01\u20131.07), liver (HR: 1.11, 95% CI: 1.03\u20131.20), and kidney (HR: 1.22, 95% CI: 1.14\u20131.31) cancers, but with a lower incidence of stomach cancer (HR: 0.94, 95% CI: 0.91\u20130.98). These associations remained significant after adjustment for multiple testing. DBP was associated with higher incidences of thyroid, esophageal, colorectal, kidney, and corpus uteri cancers, but with a lower incidence of stomach cancer. The associations between SBP and incidences of thyroid, esophageal, colorectal, liver, and kidney cancers were confirmed in the Korean National Health Insurance Service database.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Medication-na\u00efve BP was associated with higher incidences of thyroid, esophageal, colorectal, liver, and kidney cancers. Uncovering the underlying mechanisms for our results may help identify novel therapeutic approach for hypertension and cancer.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpac054","type":"journal-article","created":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T11:06:51Z","timestamp":1651403211000},"page":"731-739","source":"Crossref","is-referenced-by-count":22,"title":["Medication-Na\u00efve Blood Pressure and Incident Cancers: Analysis of 2 Nationwide Population-Based Databases"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2553-6170","authenticated-orcid":false,"given":"Hidehiro","family":"Kaneko","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan"},{"name":"Department of Advanced Cardiology, The University of Tokyo , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Yano","sequence":"additional","affiliation":[{"name":"YCU Center for Novel and Exploratory Clinical Trials, Yokohama City University Hospital , Yokohama , Japan"},{"name":"Department of Family Medicine and Community Health, Duke University , Durham, North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeok-Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Yonsei University College of Medicine , Seoul , Korea"},{"name":"Department of Internal Medicine, Yonsei University College of Medicine , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hokyou","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Yonsei University College of Medicine , Seoul , Korea"},{"name":"Department of Internal Medicine, Yonsei University College of Medicine , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate School of Medicine, The University of Tokyo , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kojiro","family":"Morita","sequence":"additional","affiliation":[{"name":"Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Fukui","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhito","family":"Fujiu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan"},{"name":"Department of Advanced Cardiology, The University of Tokyo , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan"},{"name":"Department of Cardiology, New Tokyo Hospital , Matsudo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunao","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Cardiology, New Tokyo Hospital , Matsudo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Michihata","sequence":"additional","affiliation":[{"name":"Department of Health Services Research, The University of Tokyo , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisuke","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Health Services Research, The University of Tokyo , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norifumi","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yokoo","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Kagawa University , Kagawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Node","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Saga University , Saga , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J","family":"Viera","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Community Health, Duke University , Durham, North Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Muntner","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama at Birmingham , Birmingham, Alabama , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Oparil","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon Chang","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Yonsei University College of Medicine , Seoul , Korea"},{"name":"Department of Internal Medicine, Yonsei University College of Medicine , Seoul , Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Yasunaga","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issei","family":"Komuro","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,4]]},"reference":[{"key":"2022080108594326100_CIT0001","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1161\/CIRCULATIONAHA.115.020406","article-title":"Shared risk factors in cardiovascular disease and cancer","volume":"133","author":"Koene","year":"2016","journal-title":"Circulation"},{"key":"2022080108594326100_CIT0002","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/s41440-019-0284-9","article-title":"The Japanese Society of Hypertension guidelines for the management of hypertension (JSH 2019)","volume":"42","author":"Umemura","year":"2019","journal-title":"Hypertens Res"},{"key":"2022080108594326100_CIT0003","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1161\/HYPERTENSIONAHA.111.189258","article-title":"Blood pressure and risk of cancer incidence and mortality in the Metabolic Syndrome and Cancer Project","volume":"59","author":"Stocks","year":"2012","journal-title":"Hypertension"},{"key":"2022080108594326100_CIT0004","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1002\/ijc.32576","article-title":"Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition","volume":"146","author":"Christakoudi","year":"2020","journal-title":"Int J Cancer"},{"key":"2022080108594326100_CIT0005","doi-asserted-by":"crossref","first-page":"8565","DOI":"10.1038\/s41598-019-45014-4","article-title":"Association between blood pressure and risk of cancer development: a systematic review and meta-analysis of observational studies","volume":"9","author":"Seretis","year":"2019","journal-title":"Sci Rep"},{"key":"2022080108594326100_CIT0006","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.18632\/aging.102699","article-title":"Antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis","volume":"12","author":"Xie","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"2022080108594326100_CIT0007","doi-asserted-by":"crossref","first-page":"247","DOI":"10.14740\/jocmr3744","article-title":"Association between the use of thiazide diuretics and the risk of skin cancers: a meta-analysis of observational studies","volume":"11","author":"Shin","year":"2019","journal-title":"J Clin Med Res"},{"key":"2022080108594326100_CIT0008","doi-asserted-by":"crossref","first-page":"e3600","DOI":"10.1097\/MD.0000000000003600","article-title":"Angiotensin II receptor blockers and cancer risk: a meta-analysis of randomized controlled trials","volume":"95","author":"Zhao","year":"2016","journal-title":"Medicine (Baltim)"},{"key":"2022080108594326100_CIT0009","doi-asserted-by":"crossref","first-page":"k4209","DOI":"10.1136\/bmj.k4209","article-title":"Angiotensin converting enzyme inhibitors and risk of lung cancer: population based cohort study","volume":"363","author":"Hicks","year":"2018","journal-title":"BMJ"},{"key":"2022080108594326100_CIT0010","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1111\/cas.14870","article-title":"Long-term antihypertensive drug use and risk of cancer: the Japan Public Health Center-based prospective study","volume":"112","author":"Matsui","year":"2021","journal-title":"Cancer Sci"},{"key":"2022080108594326100_CIT0011","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1161\/CIRCULATIONAHA.120.052624","article-title":"Association of blood pressure classification using the 2017 American college of Cardiology\/American Heart Association blood pressure guideline with risk of heart failure and atrial fibrillation","volume":"143","author":"Kaneko","year":"2021","journal-title":"Circulation"},{"key":"2022080108594326100_CIT0012","doi-asserted-by":"crossref","first-page":"e017963","DOI":"10.1161\/JAHA.120.017963","article-title":"Association of isolated diastolic hypertension based on the cutoff value in the 2017 American College of Cardiology\/American Heart Association blood pressure guidelines with subsequent cardiovascular events in the general population","volume":"9","author":"Kaneko","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"2022080108594326100_CIT0013","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1016\/j.jacc.2020.09.545","article-title":"Association of cardiovascular health metrics with subsequent cardiovascular disease in young adults","volume":"76","author":"Kaneko","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2022080108594326100_CIT0014","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/105294199277860","article-title":"The International Conference on Harmonization Good Clinical Practice guideline","volume":"6","author":"Dixon","year":"1998","journal-title":"Qual Assur"},{"key":"2022080108594326100_CIT0015","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1007\/s00125-020-05253-x","article-title":"An atlas on risk factors for type 2 diabetes: a wide-angled Mendelian randomisation study","volume":"63","author":"Yuan","year":"2020","journal-title":"Diabetologia"},{"key":"2022080108594326100_CIT0016","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.2337\/dc18-2217","article-title":"Plasma amino acids and incident type 2 diabetes in patients with coronary artery disease","volume":"42","author":"McCann","year":"2019","journal-title":"Diabetes Care"},{"key":"2022080108594326100_CIT0017","first-page":"799","article-title":"Data resource profile: the National Health Information Database of the National Health Insurance Service in South Korea","volume":"46","author":"Cheol Seong","year":"2017","journal-title":"Int J Epidemiol"},{"key":"2022080108594326100_CIT0018","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1161\/CIRCULATIONAHA.119.044838","article-title":"Cardiovascular risk of isolated systolic or diastolic hypertension in young adults","volume":"141","author":"Lee","year":"2020","journal-title":"Circulation"},{"key":"2022080108594326100_CIT0019","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1097\/HJH.0000000000001286","article-title":"Blood pressure and kidney cancer risk: meta-analysis of prospective studies","volume":"35","author":"Hidayat","year":"2017","journal-title":"J Hypertens"},{"key":"2022080108594326100_CIT0020","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/CEJ.0000000000000578","article-title":"The association between hypertension and colorectal cancer: a meta-analysis of observational studies","volume":"30","author":"Xuan","year":"2021","journal-title":"Eur J Cancer Prev"},{"key":"2022080108594326100_CIT0021","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1161\/HYPERTENSIONAHA.120.15317","article-title":"ACE (angiotensin-converting enzyme) inhibitors\/angiotensin receptor blockers are associated with lower colorectal cancer risk: a territory-wide study with propensity score analysis","volume":"76","author":"Cheung","year":"2020","journal-title":"Hypertension"},{"key":"2022080108594326100_CIT0022","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nrurol.2010.46","article-title":"Epidemiology and risk factors for kidney cancer","volume":"7","author":"Chow","year":"2010","journal-title":"Nat Rev Urol"},{"key":"2022080108594326100_CIT0023","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1080\/01635581.2015.1040517","article-title":"Dietary factors affecting thyroid cancer risk: a meta-analysis","volume":"67","author":"Cho","year":"2015","journal-title":"Nutr Cancer"},{"key":"2022080108594326100_CIT0024","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s12011-019-01668-9","article-title":"Effects of excessive iodine intake on blood glucose, blood pressure, and blood lipids in adults","volume":"192","author":"Liu","year":"2019","journal-title":"Biol Trace Elem Res"},{"key":"2022080108594326100_CIT0025","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/ajg.2014.71","article-title":"The synergistic effects of alcohol and tobacco consumption on the risk of esophageal squamous cell carcinoma: a meta-analysis","volume":"109","author":"Prabhu","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"2022080108594326100_CIT0026","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/HJH.0b013e32833310e0","article-title":"The association between smoking and hypertension in a population-based sample of Vietnamese men","volume":"28","author":"Thuy","year":"2010","journal-title":"J Hypertens"},{"key":"2022080108594326100_CIT0027","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1093\/eurheartj\/eht081","article-title":"Exploring causal associations between alcohol and coronary heart disease risk factors: findings from a Mendelian randomization study in the Copenhagen General Population Study","volume":"34","author":"Lawlor","year":"2013","journal-title":"Eur Heart J"},{"key":"2022080108594326100_CIT0028","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1002\/hep.23527","article-title":"The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis","volume":"51","author":"Ascha","year":"2010","journal-title":"Hepatology"},{"key":"2022080108594326100_CIT0029","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cgh.2011.01.023","article-title":"Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma","volume":"9","author":"Yasui","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2022080108594326100_CIT0030","doi-asserted-by":"crossref","first-page":"9512707","DOI":"10.1155\/2020\/9512707","article-title":"Gastric cancer in young adults: a different clinical entity from carcinogenesis to prognosis","volume":"2020","author":"Li","year":"2020","journal-title":"Gastroenterol Res Pract"},{"key":"2022080108594326100_CIT0031","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.7150\/jca.27490","article-title":"Lung cancer in young adults aged 35 years or younger: a full-scale analysis and review","volume":"10","author":"Liu","year":"2019","journal-title":"J Cancer"},{"key":"2022080108594326100_CIT0032","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/jjco\/hyi054","article-title":"Trends in lung cancer mortality among young adults in Japan","volume":"35","author":"Marugame","year":"2005","journal-title":"Jpn J Clin Oncol"},{"key":"2022080108594326100_CIT0033","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.je.2016.09.009","article-title":"Validity of diagnoses, procedures, and laboratory data in Japanese administrative data","volume":"27","author":"Yamana","year":"2017","journal-title":"J Epidemiol"},{"key":"2022080108594326100_CIT0034","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1677\/joe.0.0670143","article-title":"The biosynthesis of hormones by non-endocrine tumours\u2014a review","volume":"67","author":"Rees","year":"1975","journal-title":"J Endocrinol"}],"container-title":["American Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajh\/advance-article-pdf\/doi\/10.1093\/ajh\/hpac054\/44397204\/hpac054.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/35\/8\/731\/45042129\/hpac054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/35\/8\/731\/45042129\/hpac054.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T09:00:44Z","timestamp":1659344444000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajh\/article\/35\/8\/731\/6580567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,4]]},"references-count":34,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,5,4]]},"published-print":{"date-parts":[[2022,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ajh\/hpac054","relation":{},"ISSN":["0895-7061","1941-7225"],"issn-type":[{"value":"0895-7061","type":"print"},{"value":"1941-7225","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8,1]]},"published":{"date-parts":[[2022,5,4]]}}}