{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:03:32Z","timestamp":1768543412105,"version":"3.49.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["1-16-1CTS-015"],"award-info":[{"award-number":["1-16-1CTS-015"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA086862"],"award-info":[{"award-number":["P30 CA086862"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Patients with type 2 diabetes mellitus (T2DM) have increased cardiovascular risk due to elevated blood pressure (BP). As low levels of nitric oxide (NO) may contribute to increased BP, we determined if increasing NO bioavailability via eight weeks of supplementation with beetroot juice containing inorganic nitrate\/nitrite (4.03 mmol nitrate, 0.29 mmol nitrite) improves peripheral and central BP relative to nitrate\/nitrite-depleted beetroot juice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Peripheral and central BP were assessed at heart-level in supine subjects using a brachial artery catheter and applanation tonometry, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Nitrate\/nitrite supplementation reduced peripheral systolic BP (148 \u00b1 16 to 142 \u00b1 18 mm Hg, P &amp;lt; 0.05) but not placebo (150 \u00b1 19 to 149 \u00b1 17 mm Hg, P = 0.93); however, diastolic BP was unaffected (supplement-by-time P = 0.08). Central systolic BP (131 \u00b1 16 to 127 \u00b1 17 mm Hg) and augmented pressure (13.3 \u00b1 6.6 to 11.6 \u00b1 6.9 mm Hg, both P &amp;lt; 0.05) were reduced after nitrate\/nitrite, but not placebo (134 \u00b1 17 to 135 \u00b1 16 mm Hg, P = 0.62; 14.1 \u00b1 6.6 to 15.2 \u00b1 7.4 mm Hg, P = 0.20); central diastolic BP was unchanged by the interventions (supplement-by-time P = 0.16). Inorganic nitrate\/nitrite also reduced AIx (24.3 \u00b1 9.9% to 21.0 \u00b1 9.6%) whereas no changes were observed following placebo (24.6 \u00b1 9.3% to 25.6 \u00b1 9.9%, P = 0.46).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Inorganic nitrate\/nitrite supplementation improves peripheral and central BP as well as AIx in T2DM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CLINICAL TRIALS REGISTRATION<\/jats:title>\n                  <jats:p>Trial Number NCT02804932.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpac068","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T19:13:34Z","timestamp":1654024414000},"page":"803-809","source":"Crossref","is-referenced-by-count":11,"title":["Dietary Inorganic Nitrate\/Nitrite Supplementation Reduces Central and Peripheral Blood Pressure in 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J","family":"Feider","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Carver College of Medicine, University of Iowa , Iowa City, Iowa , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Hanada","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Carver College of Medicine, University of Iowa , Iowa City, Iowa , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4564-8604","authenticated-orcid":false,"given":"Darren P","family":"Casey","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy & Rehabilitation Science, Carver College of Medicine, University of Iowa , Iowa City, Iowa , USA"},{"name":"Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa , Iowa City, Iowa , USA"},{"name":"Fraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa , Iowa City, Iowa , 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