{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T13:13:15Z","timestamp":1766754795370,"version":"3.37.3"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["5R01MD005849","P50 MD017351"],"award-info":[{"award-number":["5R01MD005849","P50 MD017351"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Robert Wood Johnson Foundation Physician Faculty Scholars Program"},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R01 HL153607","R01 HL163377","R01 HL146059","R01 HL127215","K23LH125670","R21HL140381","T32 HL120822"],"award-info":[{"award-number":["R01 HL153607","R01 HL163377","R01 HL146059","R01 HL127215","K23LH125670","R21HL140381","T32 HL120822"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"American Heart Association Health Equity Research Network"},{"DOI":"10.13039\/100009931","name":"MDHHS","doi-asserted-by":"publisher","award":["CDC\u00a01815","1816","1817"],"award-info":[{"award-number":["CDC\u00a01815","1816","1817"]}],"id":[{"id":"10.13039\/100009931","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MHEF","award":["R-1907-144972"],"award-info":[{"award-number":["R-1907-144972"]}]},{"DOI":"10.13039\/100019294","name":"VA Office of Rural Health","doi-asserted-by":"crossref","award":["ORH-10808"],"award-info":[{"award-number":["ORH-10808"]}],"id":[{"id":"10.13039\/100019294","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Left ventricular hypertrophy (LVH) and vitamin D deficiency have been linked to hypertension (HTN) and cardiovascular disease, particularly in African Americans (AAs). Our objective was to determine if the addition of vitamin D to antihypertensive therapy would lead to greater regression of LV mass index (LVMI) as determined by cardiac magnetic resonance (CMR) after 1 year in vitamin D deficient AA patients with uncontrolled HTN and LVH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>This study was a randomized, double-blind, placebo-controlled, single-center study. AA patients with HTN (systolic blood pressure [BP] &amp;gt;160 mm Hg), increased LVMI, and vitamin D deficiency (&amp;lt;20 ng\/ml) were randomized. All patients received antihypertensive therapy combined with biweekly 50,000 IU vitamin D3 (vitamin D group, n = 55) or placebo (placebo group, n = 58).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>At 1 year, there were no statistical differences between the vitamin D and placebo groups in LVMI (\u221214.1 \u00b1 14.6 vs. \u221216.9 \u00b1 13.1 g\/m2; P = 0.34) or systolic BP (\u221225.6 \u00b1 32.1 vs. \u221225.7 \u00b1 25.6 mm Hg; P = 0.99) reduction, respectively. Serum vitamin D levels increased significantly in the vitamin D group compared with placebo (12.7 \u00b1 2.0 vs. 1.8 \u00b1 8.2 ng\/ml; P &amp;lt; 0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>In this high-risk cohort of AAs we did not find an association between vitamin D supplementation and differential regression of LVMI or reduction in systolic BP. However, our study suffered from a small sample size with low statistical power precluding a definitive conclusion on the therapeutic benefit of vitamin D in such patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CLINICAL TRIALS REGISTRATION<\/jats:title>\n                  <jats:p>Trial Number NCT01360476. Full trial protocol is available from corresponding author.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpac096","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T12:45:06Z","timestamp":1661431506000},"page":"50-62","source":"Crossref","is-referenced-by-count":8,"title":["Does Vitamin D Provide Added Benefit to Antihypertensive Therapy in Reducing Left Ventricular Hypertrophy Determined by Cardiac Magnetic Resonance?"],"prefix":"10.1093","volume":"36","author":[{"given":"Phillip D","family":"Levy","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Wayne State University , Detroit, Michigan , USA"},{"name":"Emergency Medicine, Integrative Biosciences Center, Wayne State University , Detroit, Michigan , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9267-267X","authenticated-orcid":false,"given":"Michael J","family":"Twiner","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Wayne State University , Detroit, Michigan , USA"},{"name":"Emergency Medicine, Integrative Biosciences Center, Wayne State University , Detroit, Michigan , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron M","family":"Brody","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Wayne State University , Detroit, Michigan , USA"},{"name":"Emergency Medicine, Integrative Biosciences Center, Wayne State University , Detroit, Michigan , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachelle","family":"Dawood","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Wayne State University , Detroit, Michigan , USA"},{"name":"Emergency Medicine, Integrative Biosciences Center, Wayne State University , Detroit, Michigan , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Wayne State University , Detroit, Michigan , USA"},{"name":"Emergency Medicine, Integrative Biosciences Center, Wayne State University , Detroit, Michigan , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LynnMarie","family":"Mango","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Wayne State University , Detroit, Michigan , USA"},{"name":"Emergency Medicine, Integrative Biosciences Center, Wayne State University , Detroit, Michigan , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gowland","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Wayne State University , Detroit, Michigan , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Grandits","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, School of Public Health, University of Minnesota , Minneapolis, Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Svendsen","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, School of Public Health, University of Minnesota , Minneapolis, Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewart Mark","family":"Haacke","sequence":"additional","affiliation":[{"name":"Department of Radiology and College of Engineering, Wayne State University , Detroit, Michigan , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine, University of Washington , Seattle, Washington , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Emergency Medicine, Integrative Biosciences Center, Wayne State University , Detroit, Michigan , USA"},{"name":"Department of Family Medicine and Public Health Sciences, Wayne State University , Detroit, Michigan , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candace D","family":"McNaughton","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Vanderbilt University Medical Center and the Geriatric Research Education Clinical Center, Tennessee Valley Healthcare System VA Medical Center , Nashville, Tennessee , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M","family":"Flack","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Southern Illinois University , Springfield, Illinois , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,8,26]]},"reference":[{"key":"2022122716421868900_CIT0001","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1056\/NEJMsa012979","article-title":"Contribution of major diseases to disparities in mortality","volume":"347","author":"Wong","year":"2002","journal-title":"N Engl J Med"},{"key":"2022122716421868900_CIT0002","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1161\/01.HYP.0000252676.46043.18","article-title":"Prevalence, awareness, treatment, and control of hypertension among United States adults 1999\u20132004","volume":"49","author":"Ong","year":"2007","journal-title":"Hypertension"},{"key":"2022122716421868900_CIT0003","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.amjhyper.2004.06.001","article-title":"Racial\/ethnic differences in hypertension and hypertension treatment and control in the multi-ethnic study of atherosclerosis (MESA)","volume":"17","author":"Kramer","year":"2004","journal-title":"Am J Hypertens"},{"key":"2022122716421868900_CIT0004","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1161\/01.HYP.0000169972.96201.8e","article-title":"Left ventricular hypertrophy is more prevalent in blacks than whites in the general population: the Dallas Heart Study","volume":"46","author":"Drazner","year":"2005","journal-title":"Hypertension"},{"key":"2022122716421868900_CIT0005","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jash.2014.02.010","article-title":"Blood pressure control and perceived health status in African Americans with subclinical hypertensive heart disease","author":"Burla","year":"2014","journal-title":"J Am Soc Hypertens"},{"key":"2022122716421868900_CIT0006","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1524-6175.2003.01246.x","article-title":"High prevalence of target organ damage in young, African American inner-city men with hypertension","volume":"5","author":"Post","year":"2003","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"2022122716421868900_CIT0007","first-page":"S117","article-title":"Prevalence and predictors of preclinical cardiac dysfunction in asymptomatic hypertensive patients in an urban emergency department","volume":"16","author":"Levy","year":"2009","journal-title":"Acad Emerg Med"},{"key":"2022122716421868900_CIT0008","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1161\/HYPERTENSIONAHA.109.136655","article-title":"Regression of left ventricular mass by antihypertensive treatment: a meta-analysis of randomized comparative studies","volume":"54","author":"Fagard","year":"2009","journal-title":"Hypertension"},{"key":"2022122716421868900_CIT0009","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1001\/jama.292.19.2350","article-title":"Prognostic significance of left ventricular mass change during treatment of hypertension","volume":"292","author":"Devereux","year":"2004","journal-title":"JAMA"},{"key":"2022122716421868900_CIT0010","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1001\/jama.292.19.2343","article-title":"Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatment and the prediction of major cardiovascular events","volume":"292","author":"Okin","year":"2004","journal-title":"JAMA"},{"key":"2022122716421868900_CIT0011","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1681\/ASN.2005121336","article-title":"Evaluation of subclinical target organ damage for risk assessment and treatment in the hypertensive patients: left ventricular hypertrophy","volume":"17","author":"Agabiti-Rosei","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"2022122716421868900_CIT0012","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0167-5273(00)00249-7","article-title":"Effects of enalapril and isradipine alone and in combination on blood pressure, renal function and echocardiographic parameters in mild hypertension","volume":"74","author":"De Rosa","year":"2000","journal-title":"Int J Cardiol"},{"key":"2022122716421868900_CIT0013","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/CIRCULATIONAHA.107.706127","article-title":"Vitamin D deficiency and risk of cardiovascular disease","volume":"117","author":"Wang","year":"2008","journal-title":"Circulation"},{"key":"2022122716421868900_CIT0014","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(05)60827-6","article-title":"Ultraviolet B and blood pressure","volume":"352","author":"Krause","year":"1998","journal-title":"Lancet"},{"key":"2022122716421868900_CIT0015","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.amjhyper.2007.01.017","article-title":"Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey","volume":"20","author":"Scragg","year":"2007","journal-title":"Am J Hypertens"},{"key":"2022122716421868900_CIT0016","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1001\/archinte.167.11.1159","article-title":"Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey","volume":"167","author":"Martins","year":"2007","journal-title":"Arch Intern Med"},{"key":"2022122716421868900_CIT0017","doi-asserted-by":"crossref","first-page":"V34","DOI":"10.1359\/jbmr.07s220","article-title":"Vitamin D economy in blacks","volume":"22","author":"Cosman","year":"2007","journal-title":"J Bone Miner Res"},{"key":"2022122716421868900_CIT0018","doi-asserted-by":"crossref","first-page":"E03","DOI":"10.5888\/pcd17.190307","article-title":"Effect of vitamin D on blood pressure and hypertension in the general population: an update meta-analysis of cohort studies and randomized controlled trials","volume":"17","author":"Zhang","year":"2020","journal-title":"Prev Chronic Dis"},{"key":"2022122716421868900_CIT0019","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/HYPERTENSIONAHA.111.00659","article-title":"Effect of vitamin D supplementation on blood pressure in blacks","volume":"61","author":"Forman","year":"2013","journal-title":"Hypertension"},{"key":"2022122716421868900_CIT0020","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1161\/hy0302.104674","article-title":"Assessment of left ventricular mass by cardiovascular magnetic resonance","volume":"39","author":"Myerson","year":"2002","journal-title":"Hypertension"},{"key":"2022122716421868900_CIT0021","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1161\/01.CIR.64.6.1227","article-title":"Comparative reproducibility and validity of systems for assessing cardiovascular functional class: advantages of a new specific activity scale","volume":"64","author":"Goldman","year":"1981","journal-title":"Circulation"},{"key":"2022122716421868900_CIT0022","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1161\/HYPERTENSIONAHA.109.130641","article-title":"Magnetic resonance imaging left ventricular mass reduction with fixed-dose angiotensin-converting enzyme inhibitor-based regimens in patients with high-risk hypertension","volume":"54","author":"Reichek","year":"2009","journal-title":"Hypertension"},{"key":"2022122716421868900_CIT0023","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1161\/HYPERTENSIONAHA.110.152892","article-title":"Management of high blood pressure in Blacks: an update of the International Society on Hypertension in Blacks consensus statement","volume":"56","author":"Flack","year":"2010","journal-title":"Hypertension"},{"key":"2022122716421868900_CIT0024","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.jash.2016.10.005","article-title":"Total antihypertensive therapeutic intensity score and its relationship to blood pressure reduction","volume":"10","author":"Levy","year":"2016","journal-title":"J Am Soc Hypertens"},{"key":"2022122716421868900_CIT0025","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N Engl J Med"},{"key":"2022122716421868900_CIT0026","doi-asserted-by":"crossref","first-page":"905","DOI":"10.2215\/CJN.06510909","article-title":"Cholecalciferol supplementation in hemodialysis patients: effects on mineral metabolism, inflammation, and cardiac dimension parameters","volume":"5","author":"Matias","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"2022122716421868900_CIT0027","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1001\/jama.2010.650","article-title":"US trends in prevalence, awareness, treatment, and control of hypertension, 1988\u20132008","volume":"303","author":"Egan","year":"2010","journal-title":"JAMA"},{"key":"2022122716421868900_CIT0028","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa1809944","article-title":"Vitamin D supplements and prevention of cancer and cardiovascular disease","volume":"380","author":"Manson","year":"2019","journal-title":"N Engl J Med"},{"key":"2022122716421868900_CIT0029","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1001\/jama.2012.120","article-title":"Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial","volume":"307","author":"Thadhani","year":"2012","journal-title":"JAMA"},{"key":"2022122716421868900_CIT0030","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.annemergmed.2012.03.030","article-title":"Subclinical hypertensive heart disease in black patients with elevated blood pressure in an inner-city emergency department","volume":"60","author":"Levy","year":"2012","journal-title":"Ann Emerg Med"},{"key":"2022122716421868900_CIT0031","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/acem.13122","article-title":"Screening and treatment for subclinical hypertensive heart disease in emergency department patients with uncontrolled blood pressure: a cost-effectiveness analysis","volume":"24","author":"Twiner","year":"2017","journal-title":"Acad Emerg Med"},{"key":"2022122716421868900_CIT0032","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1017\/S0007114518000491","article-title":"Vitamin D deficiency and insufficiency among US adults: prevalence, predictors and clinical implications","volume":"119","author":"Xuefeng","year":"2018","journal-title":"Br J Nutr"},{"key":"2022122716421868900_CIT0033","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1164\/rccm.201110-1868OC","article-title":"Vitamin D deficiency, smoking, and lung function in the Normative Aging Study","volume":"186","author":"Lange","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"2022122716421868900_CIT0034","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s41110-016-0012-z","article-title":"Vitamin D role in smoking women and cardiac remodeling","volume":"41","author":"Fidelix","year":"2016","journal-title":"Nutrire"},{"key":"2022122716421868900_CIT0035","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.859793","article-title":"Insulin resistance and vitamin D deficiency: a link beyond the appearances","volume":"9","author":"Trimarco","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"2022122716421868900_CIT0036","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.nutres.2010.12.001","article-title":"Prevalence and correlates of vitamin D deficiency in US adults","volume":"31","author":"Forrest","year":"2011","journal-title":"Nutr Res"},{"key":"2022122716421868900_CIT0037","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev-med-051214-025146","article-title":"Vitamin D and cardiovascular disease","volume":"67","author":"Wang","year":"2016","journal-title":"Annu Rev Med"},{"key":"2022122716421868900_CIT0038","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1097\/HJH.0b013e32834320f9","article-title":"Blood 25-hydroxyvitamin D concentration and hypertension: a meta-analysis","volume":"29","author":"Burgaz","year":"2011","journal-title":"J Hypertens"},{"key":"2022122716421868900_CIT0039","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/ki.2010.22","article-title":"Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes","volume":"77","author":"Deb","year":"2010","journal-title":"Kidney Int"},{"key":"2022122716421868900_CIT0040","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1161\/CIRCULATIONAHA.114.011732","article-title":"Vitamin D therapy in individuals with prehypertension or hypertension: the DAYLIGHT trial","volume":"131","author":"Arora","year":"2015","journal-title":"Circulation"}],"container-title":["American Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajh\/advance-article-pdf\/doi\/10.1093\/ajh\/hpac096\/47162615\/hpac096.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/36\/1\/50\/48423433\/hpac096.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/36\/1\/50\/48423433\/hpac096.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T16:45:59Z","timestamp":1672159559000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajh\/article\/36\/1\/50\/6675838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,26]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,8,26]]},"published-print":{"date-parts":[[2023,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ajh\/hpac096","relation":{},"ISSN":["0895-7061","1941-7225"],"issn-type":[{"type":"print","value":"0895-7061"},{"type":"electronic","value":"1941-7225"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,8,26]]}}}