{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:56:11Z","timestamp":1789242971069,"version":"build-2803163510"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Uncertainty remains over the relationship between blood pressure (BP) variability (BPV), measured in hospital settings, and clinical outcomes following acute ischemic stroke (AIS). We examined the association between within-person systolic blood pressure (SBP) variability (SBPV) during hospitalization and readmission-free survival, all-cause readmission, or all-cause mortality 1 year after AIS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>In a cohort of 862 consecutive patients (age [mean \u00b1 SD] 75 \u00b1 15 years, 55% women) with AIS (2005\u20132018, follow-up through 2019), we measured SBPV as quartiles of standard deviations (SD) and coefficient of variation (CV) from a median of 16 SBP readings obtained throughout hospitalization.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>In the cumulative cohort, the measured SD and CV of SBP in mmHg were 16 \u00b1 6 and 10 \u00b1 5, respectively. The hazard ratios (HR) for readmission-free survival between the highest vs. lowest quartiles were 1.44 (95% confidence interval [CI] 1.04\u20131.81) for SD and 1.29 (95% CI 0.94\u20131.78) for CV after adjustment for demographics and comorbidities. Similarly, incident readmission or mortality remained consistent between the highest vs. lowest quartiles of SD and CV (readmission: HR 1.29 [95% CI 0.90\u20131.78] for SD, HR 1.29 [95% CI 0.94\u20131.78] for CV; mortality: HR 1.15 [95% CI 0.71\u20131.87] for SD, HR 0.86 [95% CI 0.55\u20131.36] for CV).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCULSIONS<\/jats:title>\n                  <jats:p>In patients with first AIS, SBPV measured as quartiles of SD or CV based on multiple readings throughout hospitalization has no independent prognostic implications for the readmission-free survival, readmission, or mortality. This underscores the importance of overall patient care rather than a specific focus on BP parameters during hospitalization for AIS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpac106","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T19:19:23Z","timestamp":1663787963000},"page":"23-32","source":"Crossref","is-referenced-by-count":5,"title":["Within-Person Blood Pressure Variability During Hospitalization and Clinical Outcomes Following First-Ever Acute Ischemic Stroke"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7496-9856","authenticated-orcid":false,"given":"Mohammed","family":"Yousufuddin","sequence":"first","affiliation":[{"name":"Department of Hospital Internal Medicine, Mayo Clinic Health System , Austin, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M H","family":"Murad","sequence":"additional","affiliation":[{"name":"Robert D. and Patricia E. Kern Center for the Science of Healthcare Delivery, Mayo Clinic , Rochester, Minnesota , USA"},{"name":"Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic , Rochester, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Hospital Internal Medicine, Mayo Clinic Health System , Austin, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor J","family":"Ambriz","sequence":"additional","affiliation":[{"name":"Department of Hospital Internal Medicine, Mayo Clinic Health System , Austin, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine R","family":"Blocker","sequence":"additional","affiliation":[{"name":"Department of Hospital Internal Medicine, Mayo Clinic Health System , Austin, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanika","family":"Khandelwal","sequence":"additional","affiliation":[{"name":"Department of Hospital Internal Medicine, Mayo Clinic Health System , Austin, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep R","family":"Pagali","sequence":"additional","affiliation":[{"name":"Division of Hospital Internal Medicine, Mayo Clinic , Rochester, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Nanda","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Mayo Clinic , Rochester, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abdalrhim","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Mayo Clinic , Rochester, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urvish","family":"Patel","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine , Mount Sinai , New York , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar","family":"Dugani","sequence":"additional","affiliation":[{"name":"Division of Hospital Internal Medicine, Mayo Clinic , Rochester, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kogulavadanan","family":"Arumaithurai","sequence":"additional","affiliation":[{"name":"Department of Hospital Internal Medicine, Mayo Clinic Health System , Austin, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Y","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Community Internal Medicine, Mayo Clinic , Rochester, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kianoush B","family":"Kashani","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic , Rochester, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"2023042815501910300_CIT0001","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0140-6736(16)30506-2","article-title":"Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study","volume":"388","author":"O\u2019Donnell","year":"2016","journal-title":"Lancet"},{"key":"2023042815501910300_CIT0002","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1161\/CIR.0000000000001052","article-title":"Heart disease and stroke statistics-2022 update: a report from the American Heart Association","volume":"145","author":"Tsao","year":"2022","journal-title":"Circulation"},{"key":"2023042815501910300_CIT0003","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/01.HYP.0000107251.49515.c2","article-title":"Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure","volume":"42","author":"Chobanian","year":"2003","journal-title":"Hypertension"},{"key":"2023042815501910300_CIT0004","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1001\/archinte.1993.00410050036006","article-title":"Blood pressure, systolic and diastolic, and cardiovascular risks. 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