{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:36:29Z","timestamp":1787171789193,"version":"build-2736575974"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"vor","delay-in-days":47,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG064228"],"award-info":[{"award-number":["R01AG064228"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG060049"],"award-info":[{"award-number":["R01AG060049"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG066519"],"award-info":[{"award-number":["P30AG066519"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01AG052350"],"award-info":[{"award-number":["P01AG052350"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE1418060"],"award-info":[{"award-number":["DGE1418060"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer\u2019s Association","doi-asserted-by":"publisher","award":["AARG-17-532905"],"award-info":[{"award-number":["AARG-17-532905"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Elevated blood pressure (BP) variability is predictive of increased risk for stroke, cerebrovascular disease, and other vascular brain injuries, independent of traditionally studied average BP levels. However, no studies to date have evaluated whether BP variability is related to diminished cerebrovascular reactivity, which may represent an early marker of cerebrovascular dysfunction presaging vascular brain injury.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>The present study investigated BP variability and cerebrovascular reactivity in a sample of 41 community-dwelling older adults (mean age 69.6 [SD 8.7] years) without a history of dementia or stroke. Short-term BP variability was determined from BP measurements collected continuously during a 5-minute resting period followed by cerebrovascular reactivity during 5-minute hypocapnia and hypercapnia challenge induced by visually guided breathing conditions. Cerebrovascular reactivity was quantified as percent change in cerebral perfusion by pseudo-continuous arterial spin labeling (pCASL)-MRI per unit change in end-tidal CO2.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Elevated systolic BP variability was related to lower whole brain cerebrovascular reactivity during hypocapnia (\u00df = \u22120.43 [95% CI \u22120.73, \u22120.12]; P = 0.008; adjusted R2 =.11) and hypercapnia (\u00df = \u22120.42 [95% CI \u22120.77, \u22120.06]; P = 0.02; adjusted R2 = 0.19).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Findings add to prior work linking BP variability and cerebrovascular disease burden and suggest BP variability may also be related to prodromal markers of cerebrovascular dysfunction and disease, with potential therapeutic implications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpac108","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T19:34:20Z","timestamp":1663961660000},"page":"63-68","source":"Crossref","is-referenced-by-count":20,"title":["Older Adults With Higher Blood Pressure Variability Exhibit Cerebrovascular Reactivity Deficits"],"prefix":"10.1093","volume":"36","author":[{"given":"Isabel J","family":"Sible","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Southern California , Los Angeles, CA 90089 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Yun","family":"Jang","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine , Irvine, CA 92697 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubir","family":"Dutt","sequence":"additional","affiliation":[{"name":"Department 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University of California, Irvine , Irvine, CA 92697 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E","family":"Blanken","sequence":"additional","affiliation":[{"name":"San Francisco Veterans Affairs Health Care System , San Francisco, CA, 94121 , USA"},{"name":"Department of Psychiatry and Behavioral Sciences, University of California, San Francisco , San Francisco, CA, 94158 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean K","family":"Ho","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine , Irvine, CA 92697 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisa J","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Southern California , Los Angeles, CA 90089 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunima","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Psychological Science, University of California Irvine , Irvine, CA 92697 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemah","family":"Shenasa","sequence":"additional","affiliation":[{"name":"Department of Psychological Science, University of California Irvine , Irvine, CA 92697 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aim\u00e9e","family":"Gaubert","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine , Irvine, CA 92697 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine , Irvine, CA 92697 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia E","family":"Sturm","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, University of California, San Francisco , San Francisco, CA, 94158 , USA"},{"name":"Department of Neurology, University of California, San Francisco , San Francisco, CA, 94158 , USA"},{"name":"Global Brain Health Institute, University of California, San Francisco , San Francisco, CA, 94158 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Mather","sequence":"additional","affiliation":[{"name":"Davis School of Gerontology, University of Southern California , Los Angeles, CA 90089 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen E","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Center for Innovation in Brain Science, Department of Pharmacology, The University of Arizona , Tucson, AZ, 85721 , 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