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The Cox model was used to assess the hazard ratios (HRs) for home hypertension (home BP\u2005\u2265\u2005135\/\u226585 mmHg or the initiation of antihypertensive treatment) and model improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a mean 14.2-year follow-up, 225 home hypertension incidences occurred. The HR (95% confidence interval) for home hypertension incidence per 1-SD higher (=6.76 mmHg) 24-hour systolic BP (SBP) was 1.59 (1.33 to 1.90), after adjustments for possible confounding factors, including baseline home SBP. Harrell\u2019s C-statistics increased from 0.72 to 0.73 (P\u2005=\u20050.11) when 24-hour SBP was added to the basic 10-year home hypertension prediction model, which includes sex, age, body mass index, smoking status, office SBP, and baseline home SBP. Continuous net reclassification improvement (0.53, P\u2005&amp;lt;\u20050.0001) and integrated discrimination improvement (0.028, P\u2005=\u20050.0014) revealed improvement in the model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A total of 24-hour SBP could be an independent predictor of future home hypertension. Home BP and 24-hour BP can longitudinally influence each other in the long term.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ajh\/hpac121","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T15:04:12Z","timestamp":1666969452000},"page":"151-158","source":"Crossref","is-referenced-by-count":2,"title":["Association Between Ambulatory Blood Pressure and Risk of Home Hypertension in a Normotensive Population: The Ohasama Study"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-9860","authenticated-orcid":false,"given":"Shingo","family":"Nakayama","sequence":"first","affiliation":[{"name":"Division of Nephrology and Endocrinology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University , Sendai , Japan"},{"name":"Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University , Sendai , 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