{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:21:46Z","timestamp":1780410106966,"version":"3.54.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T00:00:00Z","timestamp":1675468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070439"],"award-info":[{"award-number":["82070439"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070440"],"award-info":[{"award-number":["82070440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Research Program of Shaanxi Province","award":["2020GCZX-13"],"award-info":[{"award-number":["2020GCZX-13"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["xzy012022045"],"award-info":[{"award-number":["xzy012022045"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Xi\u2019an Children\u2019s Hospital Research Grant","award":["2020A02"],"award-info":[{"award-number":["2020A02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hydrogen sulfide (H2S) is widely distributed throughout the nervous system with various antioxidant and anti-inflammatory properties. Hypertension involves an increase in reactive oxygen species (ROS) and inflammation in the hypothalamic paraventricular nucleus (PVN). However, it is unclear how H2S in PVN affects hypertension.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Our study used spontaneously hypertensive rats (SHR) and control Wistar Kyoto (WKY) rats, microinjected with adenovirus-associated virus (AAV)-CBS (cystathionine beta-synthase overexpression) or AAV-ZsGreen in bilateral PVN, or simultaneously injected with virus-carrying nuclear factor erythroid 2-related factor 2 (Nrf2)-shRNA for 4 weeks. Blood pressure (BP) and plasma noradrenaline level were detected, and the PVN was collected. Finally, levels of CBS, H2S, Nrf2, Fra-LI, ROS, gp91phox, p47phox, superoxide dismutase 1, interleukin (IL)-1\u03b2, IL-6, IL-10, tumor necrosis factor-\u03b1, tyrosine hydroxylase, and glutamate decarboxylase 67 were measured.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found that AAV-CBS increased H2S in the PVN, and BP, neuronal activation, oxidative stress, and inflammation of PVN were substantially reduced. Furthermore, endogenous H2S in the PVN activated Nrf2 and corrected the PVN\u2019s imbalance of excitatory and inhibitory neurotransmitters. However, Nrf2 knockdown in the PVN was similarly observed to abolish the beneficial effect of H2S on hypertension.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The findings imply that endogenous H2S in SHR PVN is reduced, and PVN endogenous H2S can alleviate hypertension via Nrf2-mediated antioxidant and anti-inflammatory effects.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpad012","type":"journal-article","created":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T14:50:40Z","timestamp":1675522240000},"page":"306-315","source":"Crossref","is-referenced-by-count":15,"title":["Hypothalamic Paraventricular Nucleus Hydrogen Sulfide Exerts Antihypertensive Effects in Spontaneously Hypertensive Rats via the Nrf2 Pathway"],"prefix":"10.1093","volume":"36","author":[{"given":"Wen-Jie","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Physiology and Pathophysiology, Xi\u2019an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China , Xi\u2019an , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, Xi\u2019an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China , Xi\u2019an , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, Xi\u2019an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China , Xi\u2019an , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, Xi\u2019an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China , Xi\u2019an , China"},{"name":"Department of Pharmacology, School of Basic Medical Sciences, Jiamusi University , Jiamusi , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, Xi\u2019an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China , Xi\u2019an , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-An","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, Xi\u2019an Jiaotong University School of Basic Medical Sciences, Shaanxi Engineering and Research Center of Vaccine, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China , Xi\u2019an , China"},{"name":"Institute of Pediatric Diseases, Xi\u2019an Children\u2019s Hospital , Xi\u2019an , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Shanxi Datong University School of Medicine , Datong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Jun","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, and the Department 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