{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:28:02Z","timestamp":1788449282157,"version":"build-2803163510"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In the original SPRINT article, age was categorized at 75 years, which was contrary to many previous clinical trials which is at 60 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The SPRINT trial randomized 9,361 hypertensive patients to a target blood pressure of &amp;lt;120 vs. &amp;lt;140 mm Hg (intensive vs. standard treatment, respectively). Age was re-categorized as &amp;lt;60 and \u226560 years and hazard ratios (HRs) were calculated with 95% confidence intervals (CIs) for outcomes and adverse events.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Intensive treatment reduced primary outcome significantly in both &amp;lt;60 and \u226560 years of age subgroups with a relative risk reduction (RRR) of 36% and 22%, respectively, and HR of 0.58 [95% CI, 0.36\u20130.94] and 0.78 [95% CI, 0.65\u20130.93], respectively. Although the intensive treatment rendered no effect on myocardial infarction (MI) in the overall comparison, it significantly reduced MI in patients &amp;lt;60 years of age with an RRR of 58% and HR of 0.39 [95% CI, 0.17\u20130.91]. In the \u226560-year age subgroup, reduced heart failure incidence was noted after intensive treatment, including death from other cardiovascular causes; however, these were not observed in the &amp;lt;60-year age subgroup. Intensive treatment resulted in significant hypotension, syncope, acute renal failure, or acute kidney injury in the \u226560-year age group; conversely, the risk of these adverse effects in patients &amp;lt;60 years of age did not increase.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Intensive blood pressure control is beneficial for elderly patients (age \u226560 years), albeit with increased risk of adverse events.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpad039","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T01:10:09Z","timestamp":1682644209000},"page":"491-497","source":"Crossref","is-referenced-by-count":6,"title":["Intensive Blood Pressure Control and Cardiovascular Outcomes in Elderly Patients: A Secondary Analysis of SPRINT Study Based on a 60-Year Age Cutoff"],"prefix":"10.1093","volume":"36","author":[{"given":"Manal F","family":"Cheema","sequence":"first","affiliation":[{"name":"Department of Medicine, CMH Lahore Medical College & IOD , Lahore , Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9739-3506","authenticated-orcid":false,"given":"Zeeshan","family":"Butt","sequence":"additional","affiliation":[{"name":"Department of Medicine, Integrated Medical Care Hospital , Lahore , Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samreen","family":"Gilani","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Jinnah Hospital , Lahore , Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidra","family":"Shafiq","sequence":"additional","affiliation":[{"name":"Department of Pathology, CMH Lahore Medical College , Lahore , 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