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CMV establishes lifelong, latent infections in their host. Spontaneous reactivation of CMV is usually asymptomatic, but reactivation events in immunocompromised or immunosuppressed individuals can lead to severe morbidity and mortality. Moreover, herpesvirus infections have been associated with several cardiovascular and post-transplant diseases (stroke, atherosclerosis, post-transplant vasculopathy, and hypertension). Herpesviruses, including CMV, encode viral G-protein-coupled receptors (vGPCRs) that alter the host cell by hijacking signaling pathways that play important roles in the viral life cycle and these cardiovascular diseases. In this brief review, we discuss the pharmacology and signaling properties of these vGPCRs, and their contribution to hypertension. Overall, these vGPCRs can be considered attractive targets moving forward in the development of novel hypertensive therapies.<\/jats:p>","DOI":"10.1093\/ajh\/hpad045","type":"journal-article","created":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T07:29:55Z","timestamp":1683358195000},"page":"471-480","source":"Crossref","is-referenced-by-count":9,"title":["Cytomegalovirus and Cardiovascular Disease: A Hypothetical Role for Viral G-Protein-Coupled Receptors in Hypertension"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5528-0028","authenticated-orcid":false,"given":"Gisele F","family":"Bomfim","sequence":"first","affiliation":[{"name":"Institute of Health Sciences, Federal University of Mato Grosso, campus Sinop (UFMT) , Sinop, MT , Brazil"},{"name":"Cardiovascular Translational Research Center, University of South Carolina , Columbia, South Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Priviero","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Research Center, University of South Carolina , Columbia, South Carolina , USA"},{"name":"Biomedical Engineering Program, University of South Carolina , Columbia, South Carolina , USA"},{"name":"Department of Cell Biology and Anatomy, University of South Carolina , Columbia, South Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Poole","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge , Cambridge , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita C","family":"Tostes","sequence":"additional","affiliation":[{"name":"Ribeirao Preto Medical School, University of Sao Paulo (FMRP-USP) , Ribeirao Preto, SP , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge , Cambridge , UK"},{"name":"Department of Medicine, University of Cambridge , Cambridge , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Stamou","sequence":"additional","affiliation":[{"name":"University of Copenhagen , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Uline","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Research Center, University of South Carolina , Columbia, South Carolina , USA"},{"name":"Biomedical Engineering Program, University of South Carolina , Columbia, South Carolina , USA"},{"name":"Department of Chemical Engineering, University of South Carolina , Columbia, South Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R","family":"Wills","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge , Cambridge , UK"},{"name":"Cambridge Institute of Therapeutic Immunology and Infectious Disease, School of Clinical Medicine, University of Cambridge , Cambridge , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Clinton","family":"Webb","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Research Center, University of South Carolina , Columbia, South Carolina , USA"},{"name":"Biomedical Engineering Program, University of South Carolina , Columbia, South Carolina , USA"},{"name":"Department of Cell Biology and Anatomy, University of South Carolina , Columbia, South Carolina , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,6]]},"reference":[{"key":"2023081409264312500_CIT0001","first-page":"417","article-title":"Manifestations of human cytomegalovirus 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