{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:41:30Z","timestamp":1781660490540,"version":"3.54.5"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1-TR-000040"],"award-info":[{"award-number":["UL1-TR-000040"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1-TR-001079"],"award-info":[{"award-number":["UL1-TR-001079"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1-TR-001420"],"award-info":[{"award-number":["UL1-TR-001420"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The effects of the renin\u2013angiotensin\u2013aldosterone system in cardiovascular system have been described based on small studies. The aim of this study was to evaluate the relationship between aldosterone and plasma renin activity (PRA) and cardiovascular structure and function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We studied a random sample of Multi-Ethnic Study of Atherosclerosis participants who had aldosterone and PRA blood assays at 2003\u20132005 and underwent cardiac magnetic resonance at 2010. Participants taking angiotensin-converting enzyme inhibitors or angiotensin receptor blockers were excluded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The aldosterone group was composed by 615 participants, mean age 61.6 \u00b1 8.9 years, while the renin group was 580 participants, mean age 61.5 \u00b1 8.8 years and both groups had roughly 50% females. In multivariable analysis, 1 SD increment of log-transformed aldosterone level was associated with 0.07 g\/m2 higher left ventricle (LV) mass index (P = 0.04) and 0.11 ml\/m2 higher left atrium (LA) minimal volume index (P &amp;lt; 0.01). Additionally, higher log-transformed aldosterone was associated with lower LA maximum strain and LA emptying fraction (P &amp;lt; 0.01). Aldosterone levels were not significantly associated with aortic measures. Log-transformed PRA was associated with lower LV end diastolic volume index (\u03b2 standardized = 0.08, P = 0.05). PRA levels were not significantly associated with LA and aortic structural or functional differences.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Higher levels of aldosterone and PRA are associated with concentric LV remodeling changes. Moreover, aldosterone was related to deleterious LA remodeling changes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpad050","type":"journal-article","created":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T00:36:01Z","timestamp":1684542961000},"page":"517-523","source":"Crossref","is-referenced-by-count":6,"title":["Cardiovascular Interactions of Renin\u2013Angiotensin\u2013Aldosterone System Assessed by Cardiac Magnetic Resonance: The Multi-Ethnic Study of Atherosclerosis"],"prefix":"10.1093","volume":"36","author":[{"given":"Vinithra","family":"Varadarajan","sequence":"first","affiliation":[{"name":"Department of Cardiology, Johns Hopkins University , Baltimore, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateus D","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Johns Hopkins University , Baltimore, Maryland , USA"},{"name":"Department of Medicine, Federal University of Santa Maria , Santa Maria , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharath Ambale","family":"Venkatesh","sequence":"additional","affiliation":[{"name":"Department of Radiology, Johns Hopkins University , Baltimore, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Allison","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Public Health, University of California San Diego , La Jolla, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad R","family":"Ostovaneh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Johns Hopkins University , Baltimore, Maryland , USA"},{"name":"Department of Medicine, Pennsylvania State Milton S. 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University of Michigan Cardiovascular Center , Ann Arbor, Michigan , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin O","family":"Wu","sequence":"additional","affiliation":[{"name":"Office of Biostatistics Research, NHLBI, NIH , Bethesda, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell P","family":"Tracy","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Vermont , Colchester, Vermont , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Johns Hopkins Medical Institutes , Baltimore, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E","family":"Rochitte","sequence":"additional","affiliation":[{"name":"Heart Institute, University of Sao Paulo Medical School , S\u00e3o Paulo , 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