{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:35:47Z","timestamp":1762090547317,"version":"build-2065373602"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL153191"],"award-info":[{"award-number":["R01 HL153191"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24 HL152440","K24 HL159246"],"award-info":[{"award-number":["K24 HL152440","K24 HL159246"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"Department of Health and Human Services","doi-asserted-by":"publisher","award":["75N92022D00001","75N92022D00002","75N92022D00003","75N92022D00004","75N92022D00005"],"award-info":[{"award-number":["75N92022D00001","75N92022D00002","75N92022D00003","75N92022D00004","75N92022D00005"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008536","name":"Amazon Web Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008536","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cloud Credit for Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>ACC\/AHA guidelines caution against the use of antihypertensive therapy in the setting of low standing systolic BP (SBP)\u2005&amp;lt;\u2005110 mm Hg due to unclear benefits.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>The Atherosclerosis Risk in Communities (ARIC) Study measured supine and standing SBP in adults aged 45\u201364 years between 1987 and 1989. We used Cox regression to evaluate the associations of low standing SBP (&amp;lt;110 mm Hg) with risk of falls, syncope, coronary heart disease (CHD), and mortality through December 31, 2019. Falls and syncope were ascertained by hospitalization and outpatient claims; CHD events were adjudicated. Associations were examined overall and in strata of hypertension stage, 10-year atherosclerotic cardiovascular disease (ASCVD) risk, age, and sex.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Among 12,467 adults followed a median of 24 years (mean age at enrollment 54.1\u2005\u00b1\u20055.8 years, 55% women, 26% Black adults), 3,000 (24%) had a standing SBP\u2005&amp;lt;\u2005110 mm Hg. A standing SBP\u2005&amp;lt;\u2005110 mm Hg compared to standing SBP\u2005\u2265\u2005110 mm Hg was not significantly associated with falls or syncope, and was associated with a lower risk of CHD events and mortality with HRs of 1.02 (95% CI 0.94, 1.11), 1.02 (0.93, 1.11), 0.88 (0.80, 0.97), and 0.91 (0.86, 0.97), respectively. There were no clinically meaningful differences when stratified by hypertension stage, 10-year ASCVD risk, age, and sex.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>In this community-based population, low standing SBP was common and not significantly associated with falls or syncope, but was associated with a lower risk of CHD and mortality. These findings do not support screening for low standing BP as a risk factor for adverse events.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpad064","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T14:30:58Z","timestamp":1689604258000},"page":"593-601","source":"Crossref","is-referenced-by-count":3,"title":["Standing Blood Pressure and Risk of Falls, Syncope, Coronary Heart Disease, and Mortality"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8661-5174","authenticated-orcid":false,"given":"Jordan K","family":"Kondo","sequence":"first","affiliation":[{"name":"Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William B","family":"Earle","sequence":"additional","affiliation":[{"name":"Department of Medicine, Beth Israel Deaconess Medical Center , Boston, Massachusetts , 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Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela L","family":"Lutsey","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health, School of Public Health, University of Minnesota , Minneapolis, Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Coresh","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland , USA"},{"name":"Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverly Gwen","family":"Windham","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Geriatric Medicine, University of 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