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In humans, there appears to be a particularly strong genetic effect in those aged\u2005\u2265\u200590 years. An important contribution is nutrient sensing genes which confer cell resilience.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Our research has been investigating the genetic factors by longitudinal studies of American men of Japanese descent living on the island of Oahu in Hawaii. This cohort began as the Honolulu Heart Program in the mid-1960s and most subjects are now deceased.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>We previously discovered various genes containing polymorphisms associated with longevity. In recent investigations of the mechanism involved we found that the longevity genotypes ameliorated the risk of mortality posed by having a cardiometabolic disease (CMD)\u2014most prominently hypertension. For the gene FOXO3 the protective alleles mitigated the risk of hypertension, coronary heart disease (CHD) and diabetes. For the kinase MAP3K5 it was hypertension, CHD and diabetes, for the kinase receptor PIK3R1 hypertension, CHD and stroke, and for the growth hormone receptor gene (GHR) and vascular endothelial growth factor receptor 1 gene (FLT1), it was nullifying the higher mortality risk posed by hypertension. Subjects with a CMD who had a longevity genotype had similar survival as men without CMD. No variant protected against risk of death from cancer. We have postulated that the longevity-associated genotypes reduced mortality risk by effects on intracellular resilience mechanisms. In a proteomics study, 43 \u201cstress\u201d proteins and associated biological pathways were found to influence the association of FOXO3 genotype with reduced mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Our landmark findings indicate how heritable genetic components affect longevity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpad070","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T20:24:29Z","timestamp":1691612669000},"page":"631-640","source":"Crossref","is-referenced-by-count":2,"title":["Genes That Extend Lifespan May Do So by Mitigating the Increased Risk of Death Posed by Having Hypertension"],"prefix":"10.1093","volume":"36","author":[{"given":"Brian J","family":"Morris","sequence":"first","affiliation":[{"name":"Department of Research, NIH Center of Biomedical Research Excellence on Aging, Kuakini Medical Center , Honolulu, Hawaii 96817 , USA"},{"name":"Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii , Honolulu, Hawaii 96813 , USA"},{"name":"School of Medical Sciences, University of Sydney , Sydney, New South Wales 2006 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A","family":"Donlon","sequence":"additional","affiliation":[{"name":"Department of Research, NIH Center of Biomedical Research Excellence on Aging, Kuakini Medical Center , Honolulu, Hawaii 96817 , USA"},{"name":"Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii , Honolulu, Hawaii 96813 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"2023111511582079800_CIT0001","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/s41591-023-02296-6","article-title":"Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality","volume":"29","author":"Tian","year":"2023","journal-title":"Nat Med"},{"key":"2023111511582079800_CIT0002","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.bbadis.2018.08.039","article-title":"Genetic and epigenetic regulation of human aging and longevity","volume":"1865","author":"Morris","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2023111511582079800_CIT0003","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/ng0194-29","article-title":"Genetic associations with human longevity at 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