{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:08:01Z","timestamp":1785150481297,"version":"3.55.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070432"],"award-info":[{"award-number":["82070432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070435"],"award-info":[{"award-number":["82070435"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270469"],"award-info":[{"award-number":["82270469"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370426"],"award-info":[{"award-number":["82370426"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["2018YFC1704902"],"award-info":[{"award-number":["2018YFC1704902"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["2022YFC3601302"],"award-info":[{"award-number":["2022YFC3601302"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["2016YFC0900902"],"award-info":[{"award-number":["2016YFC0900902"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Commissions of Science and Technology","award":["19DZ2340200"],"award-info":[{"award-number":["19DZ2340200"]}]},{"name":"Shanghai Municipality for Strengthening the Construction of Public Health System","award":["GWV-10.1-XK05"],"award-info":[{"award-number":["GWV-10.1-XK05"]}]},{"name":"Shanghai Municipality for Strengthening the Construction of Public Health System","award":["2022LJ022"],"award-info":[{"award-number":["2022LJ022"]}]},{"DOI":"10.13039\/501100008233","name":"Shanghai Jiao Tong University School of Medicine","doi-asserted-by":"publisher","award":["2018CR010"],"award-info":[{"award-number":["2018CR010"]}],"id":[{"id":"10.13039\/501100008233","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Alcohol consumption is a proven risk factor of hypertension. In the present analysis, we investigated the use of antihypertensive medications and blood pressure control in male alcohol drinkers and non-drinkers with hypertension (systolic\/diastolic blood pressure 160\u2013199\/100\u2013119 mm Hg).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>The study participants were patients enrolled in a 12-week therapeutic study and treated with the irbesartan\/hydrochlorothiazide combination 150\/12.5 mg once daily, with the possible up-titration to 300\/12.5 mg\/day and 300\/25 mg\/day at 4 and 8 weeks of follow-up, respectively, for blood pressure control of &amp;lt;140\/90 mm Hg or &amp;lt;130\/80 mm Hg in patients with diabetes mellitus. Alcohol consumption was classified as non-drinkers and drinkers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The 68 alcohol drinkers and 168 non-drinkers had similar systolic\/diastolic blood pressure at baseline (160.8\u2005\u00b1\u200512.1\/99.8\u2005\u00b1\u20058.6 vs. 161.8\u2005\u00b1\u200511.0\/99.2\u2005\u00b1\u20058.6, P\u2005\u2265\u20050.55) and other characteristics except for current smoking (80.9% vs. 47.6%, P\u2005&amp;lt;\u20050.0001). In patients who completed the 12-week follow-up (n\u2005=\u2005215), the use of higher dosages of antihypertensive drugs was similar at 4 weeks of follow-up in drinkers and non-drinkers (10.6% vs. 12.4%, P\u2005=\u20050.70), but increased to a significantly higher proportion in drinkers than non-drinkers at 12 weeks of follow-up (54.7% vs. 36.6%, P\u2005=\u20050.01). The control rate of hypertension tended to be lower in alcohol drinkers, compared with non-drinkers, at 4 weeks of follow-up (45.6% vs. 58.9%, P\u2005=\u20050.06), but became similar at 12 weeks of follow-up (51.5% vs. 54.8%, P\u2005=\u20050.65).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>Alcohol drinkers compared with non-drinkers required a higher dosage of antihypertensive drug treatment to achieve similar blood pressure control.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CLINICAL TRIAL REGISTRY NUMBER<\/jats:title>\n                  <jats:p>NCT00670566 at www.clinicaltrials.gov.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpad091","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T19:28:25Z","timestamp":1695929305000},"page":"112-119","source":"Crossref","is-referenced-by-count":3,"title":["Alcohol Consumption and Antihypertensive Treatment Effect in Male Patients With Hypertension"],"prefix":"10.1093","volume":"37","author":[{"given":"Xiao-Fei","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Statistics, School of Public Health, Shanghai Jiao Tong University School of Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Yuan-Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics, School of Public Health, Shanghai Jiao Tong University School of Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics, School of Public Health, Shanghai Jiao Tong University School of Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Fang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-1524","authenticated-orcid":false,"given":"Ji-Guang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics, School of Public Health, Shanghai Jiao Tong University School of Medicine , Shanghai , China"},{"name":"Department of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"2024011610200520000_CIT0001","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1161\/CIRCULATIONAHA.117.032380","article-title":"Status of hypertension in China: results from the China Hypertension Survey, 2012\u20132015","volume":"137","author":"Wang","year":"2018","journal-title":"Circulation"},{"key":"2024011610200520000_CIT0002","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s12889-019-6502-1","article-title":"Patterns and trends of alcohol consumption in rural and urban areas of China: findings from the China Kadoorie Biobank","volume":"19","author":"Im","year":"2019","journal-title":"BMC Public Health"},{"key":"2024011610200520000_CIT0003","first-page":"803","article-title":"Prevalence, awareness, treatment and control rates of hypertension in Chinese adults: trend and associated factors from 1991 to 2015","volume":"25","author":"Yao","year":"2022","journal-title":"Chin Gen Pract"},{"key":"2024011610200520000_CIT0004","doi-asserted-by":"crossref","first-page":"e023995","DOI":"10.1136\/bmjopen-2018-023995","article-title":"Association of lifestyle modification and pharmacological adherence on blood pressure control among patients with hypertension at Kenyatta National Hospital, Kenya: a cross-sectional study","volume":"9","author":"Kimani","year":"2019","journal-title":"BMJ Open"},{"key":"2024011610200520000_CIT0005","doi-asserted-by":"crossref","first-page":"16","DOI":"10.7895\/ijadr.244","article-title":"Alcohol and hypertension: an analysis using The Health Survey for England, 2014","volume":"7","author":"Grovu","year":"2018","journal-title":"Int J Alcohol Drug Res"},{"key":"2024011610200520000_CIT0006","first-page":"26","article-title":"Relationship between alcohol consumption and control of hypertension among elderly Greeks. The Nemea primary care study","volume":"53","author":"Skliros","year":"2012","journal-title":"Hellenic J Cardiol"},{"key":"2024011610200520000_CIT0007","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0021-9681(87)90108-1","article-title":"Relationship between alcohol consumption and hypertension prevalence and control in a French population","volume":"40","author":"Lang","year":"1987","journal-title":"J Chronic Dis"},{"key":"2024011610200520000_CIT0008","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1177\/17423953221102626","article-title":"Association between excessive alcohol consumption and hypertension control in hypertensive patients","volume":"19","author":"Hwang","year":"2022","journal-title":"Chronic Illn"},{"key":"2024011610200520000_CIT0009","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1016\/S2468-2667(17)30003-8","article-title":"The effect of a reduction in alcohol consumption on blood pressure: a systematic review and meta-analysis","volume":"2","author":"Roerecke","year":"2017","journal-title":"Lancet Public Health"},{"key":"2024011610200520000_CIT0010","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1093\/ajh\/hpab082","article-title":"A randomized trial of home blood-pressure reduction by alcohol guidance during outpatient visits: OSAKE study","volume":"34","author":"Kabayama","year":"2021","journal-title":"Am J Hypertens"},{"key":"2024011610200520000_CIT0011","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJMoa1817591","article-title":"Alcohol abstinence in drinkers with atrial fibrillation","volume":"382","author":"Voskoboinik","year":"2020","journal-title":"N Engl J Med"},{"key":"2024011610200520000_CIT0012","first-page":"CD010022","article-title":"Alcohol intake reduction for controlling hypertension","volume":"9","author":"Acin","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"2024011610200520000_CIT0013","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s40268-013-0013-9","article-title":"Efficacy and safety of a fixed combination of irbesartan\/hydrochlorothiazide in Chinese patients with moderate to severe hypertension","volume":"13","author":"Huang","year":"2013","journal-title":"Drugs R D"},{"key":"2024011610200520000_CIT0014","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41440-020-00602-0","article-title":"A randomized controlled trial on home blood pressure monitoring and quality of care in stage 2 and 3 hypertension","volume":"44","author":"Zhang","year":"2021","journal-title":"Hypertens Res"},{"key":"2024011610200520000_CIT0015","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/MBP.0000000000000554","article-title":"Incident hyperuricemia in relation to antihypertensive therapy with the irbesartan\/hydrochlorothiazide combination","volume":"26","author":"Zhang","year":"2021","journal-title":"Blood Press Monit"},{"key":"2024011610200520000_CIT0016","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/ki.2010.462","article-title":"Evaluation of the chronic kidney disease epidemiology collaboration equation for estimating the glomerular filtration rate in multiple ethnicities","volume":"79","author":"Stevens","year":"2011","journal-title":"Kidney Int"},{"key":"2024011610200520000_CIT0017","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/ndt\/gfs491","article-title":"Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating glomerular filtration rate in the Chinese population","volume":"28","author":"Kong","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"2024011610200520000_CIT0018","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/jch.13203","article-title":"Use of physician-recommended non-pharmacological strategies for hypertension control among hypertensive patients","volume":"20","author":"Liu","year":"2018","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"2024011610200520000_CIT0019","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/jch.13761","article-title":"Utilization of antihypertensive drugs among chronic kidney disease patients: results from the Chinese cohort study of chronic kidney disease (C-STRIDE)","volume":"22","author":"Liu","year":"2020","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"2024011610200520000_CIT0020","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.kint.2019.04.032","article-title":"Considerable international variation exists in blood pressure control and antihypertensive prescription patterns in chronic kidney disease","volume":"96","author":"Alencar de Pinho","year":"2019","journal-title":"Kidney Int"},{"key":"2024011610200520000_CIT0021","first-page":"1","article-title":"Control status of ambulatory blood pressure and its relationship with arterial stiffness in the China nationwide registry of treated hypertensive patients: the REACTION-ABP study","volume":"12","author":"Li","year":"2023","journal-title":"Hypertens Res"},{"key":"2024011610200520000_CIT0022","first-page":"182","article-title":"2018 Chinese guidelines for prevention and treatment of hypertension\u2014a report of the Revision Committee of Chinese Guidelines for Prevention and Treatment of Hypertension","volume":"16","author":"Joint Committee for Guideline Revision","year":"2019","journal-title":"J Geriatr Cardiol"},{"key":"2024011610200520000_CIT0023","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nrneph.2011.175","article-title":"Diuretic use in renal disease","volume":"8","author":"Sica","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"2024011610200520000_CIT0024","first-page":"e13","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"71","author":"Whelton","year":"2018","journal-title":"Hypertension"},{"key":"2024011610200520000_CIT0025","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/MNH.0000000000000814","article-title":"Revisiting diuretic choice in chronic kidney disease","volume":"31","author":"Ali","year":"2022","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"2024011610200520000_CIT0026","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/sj.jhh.1002293","article-title":"A comparison of the efficacy and safety of irbesartan\/HCTZ combination therapy with irbesartan and HCTZ monotherapy in the treatment of moderate hypertension","volume":"22","author":"Neutel","year":"2008","journal-title":"J Hum Hypertens"}],"container-title":["American Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajh\/advance-article-pdf\/doi\/10.1093\/ajh\/hpad091\/52147498\/hpad091.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/37\/2\/112\/55253706\/hpad091.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/37\/2\/112\/55253706\/hpad091.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T10:20:57Z","timestamp":1705400457000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajh\/article\/37\/2\/112\/7285510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,28]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,9,28]]},"published-print":{"date-parts":[[2024,1,16]]}},"URL":"https:\/\/doi.org\/10.1093\/ajh\/hpad091","relation":{},"ISSN":["0895-7061","1941-7225"],"issn-type":[{"value":"0895-7061","type":"print"},{"value":"1941-7225","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2,1]]},"published":{"date-parts":[[2023,9,28]]}}}