{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:13:47Z","timestamp":1790835227856,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T00:00:00Z","timestamp":1701475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970340"],"award-info":[{"award-number":["81970340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000372"],"award-info":[{"award-number":["82000372"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170384"],"award-info":[{"award-number":["82170384"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270399"],"award-info":[{"award-number":["82270399"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515012161"],"award-info":[{"award-number":["2022A1515012161"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>It remains unclear whether systolic (SBP) and diastolic (DBP) pressure and BP response after six-minute walk test (6MWT) are associated with adverse outcomes in patients with acute heart failure (AHF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We investigated these associations in 98 AHF patients (24.5% women; mean age, 70.5 years) enrolled in the ROSE trial (The Low-dose Dopamine or Low-dose Nesiritide in Acute Heart Failure with Renal Dysfunction). The primary endpoint consisted of any death or rehospitalization within 6 months after randomization. We computed hazard ratios (HRs) of the risks associated with 1-SD increase in post-exercise BP levels and BP ratios, calculated as BP immediately after 6MWT divided by BP before 6MWT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The BP before and after 6MWT averaged 110.6\/117.5 mm Hg for SBP and 61.9\/64.7 mm Hg for DBP. In multivariable-adjusted analyses including clinic BP measured at the same day of 6MWT, higher DBP after 6MWT was associated with lower risk of the primary endpoint (HR, 0.49; 95% confidence interval [CI], 0.26\u20130.95; P\u2005=\u20050.034). Both higher SBP and DBP immediately after 6MWT were associated with lower risk of 6-month mortality (HRs, 0.39\/0.16; 95% CI, 0.17\u20130.90\/0.065\u20130.40; P\u2005\u2264\u20050.026). The post-exercise SBP ratio was associated with the risk of 6-month mortality in multivariable-adjusted analyses (HR, 0.44; P\u2005=\u20050.023).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Higher BP levels and BP ratios immediately after 6MWT conferred lower risk of adverse health outcomes. Our observations highlight that 6MWT-related BP level and response may refine risk estimates in patients hospitalized AHF and may help further investigation for the development of HF preventive strategies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpad115","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T22:45:06Z","timestamp":1701384306000},"page":"199-206","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic Significance of Blood Pressure at Rest and After Performing the Six-Minute Walk Test in Patients With Acute Heart Failure"],"prefix":"10.1093","volume":"37","author":[{"given":"Jiale","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong , China"},{"name":"NHC Key Laboratory of Assisted Circulation, Sun Yat-Sen University , Guangzhou , Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongping","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong , China"},{"name":"NHC Key Laboratory of Assisted Circulation, Sun Yat-Sen University , Guangzhou , Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong , China"},{"name":"NHC Key Laboratory of Assisted Circulation, Sun Yat-Sen University , Guangzhou , Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong , China"},{"name":"NHC Key Laboratory of Assisted Circulation, Sun Yat-Sen University , Guangzhou , Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong , China"},{"name":"NHC Key Laboratory of Assisted Circulation, Sun Yat-Sen University , Guangzhou , Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangui","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong , China"},{"name":"NHC Key Laboratory of Assisted Circulation, Sun Yat-Sen University , Guangzhou , Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan A","family":"Staessen","sequence":"additional","affiliation":[{"name":"Non-Profit Research Association Alliance for the Promotion of Preventive Medicine , Mechelen , Belgium"},{"name":"Biomedical Research Group, Faculty of Medicine, University of Leuven , Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong , China"},{"name":"NHC Key Laboratory of Assisted Circulation, Sun Yat-Sen University , Guangzhou , Guangdong , China"},{"name":"National Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Disease , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong , China"},{"name":"NHC Key Laboratory of Assisted Circulation, Sun Yat-Sen University , Guangzhou , Guangdong , China"},{"name":"National Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Disease , Guangzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Fei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong , China"},{"name":"NHC Key Laboratory of Assisted Circulation, Sun Yat-Sen University , Guangzhou , Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,12,2]]},"reference":[{"key":"2024030122145251500_CIT0001","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(17)32520-5","article-title":"Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals","volume":"391","author":"Conrad","year":"2018","journal-title":"Lancet"},{"key":"2024030122145251500_CIT0002","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"GBD 2017 Disease and Injury Incidence and Prevalence Collaborators","year":"2018","journal-title":"Lancet"},{"key":"2024030122145251500_CIT0003","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1161\/CIRCULATIONAHA.106.184461","article-title":"Assessment of functional capacity in clinical and research settings: a scientific statement from the American Heart Association Committee on Exercise, Rehabilitation, and Prevention of the Council on Clinical Cardiology and the Council on Cardiovascular Nursing","volume":"116","author":"Arena","year":"2007","journal-title":"Circulation"},{"key":"2024030122145251500_CIT0004","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ijcard.2022.01.040","article-title":"Association of improvement in functional capacity after rehabilitation with long-term survival in heart failure","volume":"352","author":"Scrutinio","year":"2022","journal-title":"Int J Cardiol"},{"key":"2024030122145251500_CIT0005","doi-asserted-by":"crossref","first-page":"e004750","DOI":"10.1161\/CIRCHEARTFAILURE.117.004750","article-title":"Pulmonary capillary wedge pressure patterns during exercise predict exercise capacity and incident heart failure","volume":"11","author":"Eisman","year":"2018","journal-title":"Circ Heart Fail"},{"key":"2024030122145251500_CIT0006","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12931-021-01895-6","article-title":"Practical guide to cardiopulmonary exercise testing in adults","volume":"23","author":"Glaab","year":"2022","journal-title":"Respir Res"},{"key":"2024030122145251500_CIT0007","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/1474515119876784","article-title":"Confirming a beneficial effect of the six-minute walk test on exercise confidence in patients with heart failure","volume":"19","author":"Toukhsati","year":"2020","journal-title":"Eur J Cardiovasc Nurs"},{"key":"2024030122145251500_CIT0008","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ijcard.2017.02.109","article-title":"Reliability, construct validity and determinants of 6-minute walk test performance in patients with chronic heart failure","volume":"240","author":"Uszko-Lencer","year":"2017","journal-title":"Int J Cardiol"},{"key":"2024030122145251500_CIT0009","doi-asserted-by":"crossref","first-page":"505969","DOI":"10.1155\/2014\/505969","article-title":"The long-term prognostic significance of 6-minute walk test distance in patients with chronic heart failure","volume":"2014","author":"Ingle","year":"2014","journal-title":"Biomed Res Int"},{"key":"2024030122145251500_CIT0010","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/ejhf.1380","article-title":"Clinical correlates and outcome associated with changes in 6-minute walking distance in patients with heart failure: findings from the BIOSTAT-CHF study","volume":"21","author":"Ferreira","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"2024030122145251500_CIT0011","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0735-1097(97)00533-0","article-title":"Cardiopulmonary exercise testing identifies low risk patients with heart failure and severely impaired exercise capacity considered for heart transplantation","volume":"31","author":"Osada","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"2024030122145251500_CIT0012","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1097\/00004872-199917121-00030","article-title":"Prognostic significance of exercise versus resting blood pressure in patients with chronic heart failure","volume":"17","author":"Fagard","year":"1999","journal-title":"J Hypertens"},{"key":"2024030122145251500_CIT0013","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1253\/circj.CJ-18-1111","article-title":"Combination of peak exercise systolic blood pressure and left atrial diameter as a novel non-spirometry prognostic predictor comparable to peak oxygen uptake for heart failure with reduced ejection fraction","volume":"83","author":"Nakanishi","year":"2019","journal-title":"Circ J"},{"key":"2024030122145251500_CIT0014","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jchf.2022.01.012","article-title":"Exercise blood pressure in heart failure with preserved and reduced ejection fraction","volume":"10","author":"Namasivayam","year":"2022","journal-title":"JACC Heart Fail"},{"key":"2024030122145251500_CIT0015","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000088257","article-title":"Exercise duration and peak systolic blood pressure are predictive of mortality in ambulatory patients with mild-moderate chronic heart failure","volume":"104","author":"Williams","year":"2005","journal-title":"Cardiology"},{"key":"2024030122145251500_CIT0016","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1536\/ihj.51.111","article-title":"Systolic blood pressure response to exercise as a predictor of mortality in patients with chronic heart failure","volume":"51","author":"Nishiyama","year":"2010","journal-title":"Int Heart J"},{"key":"2024030122145251500_CIT0017","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s00380-010-0115-z","article-title":"Prognostic significance of blood pressure response to exercise in patients with systolic heart failure","volume":"27","author":"Kallistratos","year":"2012","journal-title":"Heart Vessels"},{"key":"2024030122145251500_CIT0018","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1177\/1741826710393994","article-title":"Cardiopulmonary exercise testing and prognosis in heart failure due to systolic left ventricular dysfunction: a validation study of the European Society of Cardiology guidelines and recommendations (2008) and further developments","volume":"19","author":"Corra","year":"2012","journal-title":"Eur J Prev Cardiol"},{"key":"2024030122145251500_CIT0019","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3390\/jcm6090084","article-title":"Feasibility of serial 6-min walk tests in patients with acute heart failure","volume":"6","author":"Collins","year":"2017","journal-title":"J Clin Med"},{"key":"2024030122145251500_CIT0020","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1001\/jama.2013.282190","article-title":"Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial","volume":"310","author":"Chen","year":"2013","journal-title":"JAMA"},{"key":"2024030122145251500_CIT0021","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1161\/CIRCULATIONAHA.117.030112","article-title":"Worsening renal function in patients with acute heart failure undergoing aggressive diuresis is not associated with tubular injury","volume":"137","author":"Ahmad","year":"2018","journal-title":"Circulation"},{"key":"2024030122145251500_CIT0022","first-page":"1126","article-title":"Postexercise systolic blood pressure response: clinical application to the assessment of ischemic heart disease","volume":"58","author":"Taylor","year":"1998","journal-title":"Am Fam Physician"},{"key":"2024030122145251500_CIT0023","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.atherosclerosis.2014.08.029","article-title":"Low exercise blood pressure and risk of cardiovascular events and all-cause mortality: systematic review and meta-analysis","volume":"237","author":"Barlow","year":"2014","journal-title":"Atherosclerosis"},{"key":"2024030122145251500_CIT0024","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/CIRCHEARTFAILURE.109.881326","article-title":"Six-minute walk test and cardiopulmonary exercise testing in patients with chronic heart failure: a comparative analysis on clinical and prognostic insights","volume":"2","author":"Guazzi","year":"2009","journal-title":"Circ Heart Fail"},{"key":"2024030122145251500_CIT0025","doi-asserted-by":"crossref","first-page":"394183","DOI":"10.1155\/2015\/394183","article-title":"Cardiovascular reflexes activity and their interaction during exercise","volume":"2015","author":"Crisafulli","year":"2015","journal-title":"Biomed Res Int"},{"key":"2024030122145251500_CIT0026","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fphys.2012.00284","article-title":"Sympathetic regulation of vascular function in health and disease","volume":"3","author":"Bruno","year":"2012","journal-title":"Front Physiol"},{"key":"2024030122145251500_CIT0027","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1161\/01.HYP.0000184225.05629.51","article-title":"Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors","volume":"46","author":"Cornelissen","year":"2005","journal-title":"Hypertension"},{"key":"2024030122145251500_CIT0028","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1038\/s41440-022-01058-0","article-title":"Pathophysiology of the exaggerated blood pressure response to exercise","volume":"45","author":"Tokushige","year":"2022","journal-title":"Hypertens Res"},{"key":"2024030122145251500_CIT0029","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41392-022-01153-1","article-title":"Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics","volume":"7","author":"Chen","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"2024030122145251500_CIT0030","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41392-023-01430-7","article-title":"Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions","volume":"8","author":"Ma","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"2024030122145251500_CIT0031","doi-asserted-by":"crossref","first-page":"e13159","DOI":"10.1111\/acel.13159","article-title":"Exercise training reverses cardiac aging phenotypes associated with heart failure with preserved ejection fraction in male mice","volume":"19","author":"Roh","year":"2020","journal-title":"Aging Cell"},{"key":"2024030122145251500_CIT0032","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.yjmcc.2021.12.004","article-title":"Hallmarks of exercised heart","volume":"164","author":"Qiu","year":"2022","journal-title":"J Mol Cell Cardiol"},{"key":"2024030122145251500_CIT0033","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1161\/HYPERTENSIONAHA.121.17574","article-title":"Percutaneous intracoronary delivery of plasma extracellular vesicles protects the myocardium against ischemia-reperfusion injury in Canis","volume":"78","author":"Wang","year":"2021","journal-title":"Hypertension"}],"container-title":["American Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajh\/advance-article-pdf\/doi\/10.1093\/ajh\/hpad115\/54531980\/hpad115.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/37\/3\/199\/56724152\/hpad115.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/37\/3\/199\/56724152\/hpad115.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T22:17:57Z","timestamp":1709331477000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajh\/article\/37\/3\/199\/7457921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,2]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,12,2]]},"published-print":{"date-parts":[[2024,2,15]]}},"URL":"https:\/\/doi.org\/10.1093\/ajh\/hpad115","relation":{},"ISSN":["0895-7061","1941-7225"],"issn-type":[{"value":"0895-7061","type":"print"},{"value":"1941-7225","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3,1]]},"published":{"date-parts":[[2023,12,2]]}}}