{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:36:31Z","timestamp":1788838591755,"version":"build-2803163510"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K01 DK126972"],"award-info":[{"award-number":["K01 DK126972"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"American Heart Association Second Century Early Faculty Independence Award","award":["23SCEFIA1148464"],"award-info":[{"award-number":["23SCEFIA1148464"]}]},{"name":"University of Rochester Environmental Health Science Center","award":["NIEHS P30ES001247"],"award-info":[{"award-number":["NIEHS P30ES001247"]}]},{"name":"University of Rochester Program for Advanced Immune Bioimaging","award":["NIAID P01AI102851"],"award-info":[{"award-number":["NIAID P01AI102851"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Fifty years ago, Dr. John Laragh brought forward the \u201cvasoconstriction-volume hypothesis\u201d of hypertension. This is Ohm\u2019s Law in blood pressure regulation, explicating hypertension as a consequence of increased peripheral vascular resistance, cardiac output, or both. Resistance vessels, those of a diameter less than 200 \u03bcm, determines mean arterial pressure by controlling peripheral vascular resistance. In comparison, large capacitance arteries, particularly the aorta, confines the systolic and diastolic blood pressure in physiological range through the \u201cwindkessel effect.\u201d Loss of this cushioning function results in aortic stiffening and isolated systolic hypertension, both of which are independently associated with increased risk for coronary, cerebral, and renal diseases. Aortic stiffening is both a cause and a consequence of hypertension. On one hand, aortic stiffness precedes the onset of hypertension in populations and experimental models, and hemodynamic derangements related to aortic stiffening contributes to the development of hypertension by promoting renal dysfunction. On the other hand, the vasculature itself is a hypertensive target organ and hypertensive mechanical stretch directly induces the pathogenesis of aortic adventitial remodeling. Various cell types, including bone marrow-derived circulating fibrocytes, vascular stem cell antigen-1 positive progenitors, and endothelial to mesenchymal transition, and to a lesser extent resident fibroblasts, contribute to adventitial matrix deposition and aortic stiffening in hypertension. Vascular smooth muscle stiffness is another important contributor of aortic stiffening. Understanding the roles of immune components and specific signal pathways in the pathogenesis aortic stiffening paves the path to novel antihypertensive and anti-fibrosis therapies.<\/jats:p>","DOI":"10.1093\/ajh\/hpae006","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T12:35:45Z","timestamp":1705062945000},"page":"241-247","source":"Crossref","is-referenced-by-count":15,"title":["The Pathogenesis and Impact of Arterial Stiffening in Hypertension: The 2023 John H. Laragh Research Award"],"prefix":"10.1093","volume":"37","author":[{"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, School of Medicine & Dentistry, University of Rochester , Rochester, NY 14642 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2013-2863","authenticated-orcid":false,"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, School of Medicine & Dentistry, University of Rochester , Rochester, NY 14642 ,","place":["USA"]},{"name":"Department of Pharmacology & Physiology, School of Medicine & Dentistry, University of Rochester , Rochester, NY 14642 ,","place":["USA"]},{"name":"Environmental Health Science Center, Institute of Human Health and the Environment, University of Rochester Medical Center , Rochester, NY 14642 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"2024101708420056700_CIT0001","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1056\/NEJM197203022860901","article-title":"Essential hypertension: renin and aldosterone, heart attack and stroke","volume":"286","author":"Brunner","year":"1972","journal-title":"N Engl J Med"},{"key":"2024101708420056700_CIT0002","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1056\/NEJM197212142872401","article-title":"Propranolol inhibition of renin secretion. 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