{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T07:29:18Z","timestamp":1776065358948,"version":"3.50.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>The saline infusion test (SIT) to confirm primary aldosteronism requires infusing 2 L of normal saline over 240 minutes. Previous studies raised concerns regarding increased blood pressure and worsening hypokalemia during SIT. We aimed to evaluate the diagnostic applicability of a SIT that requires 1 L of saline infusion over 120 minutes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>A cross-sectional study, including all patients in a large medical center who underwent SIT from 1 January 2015 to 30 April 2023. Blood samples were drawn for baseline renin and aldosterone (t\u2005=\u20050) after 2 hours (t\u2005=\u2005120 min) and after 4 hours (t\u2005=\u2005240 min) of saline infusion. We used ROC analysis to evaluate the sensitivity and specificity of various aldosterone cut-off values at t\u2005=\u2005120 to confirm primary aldosteronism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The final analysis included 62 patients. A ROC analysis yielded 97% specificity and 90% sensitivity for a plasma aldosterone concentration (PAC) of 397 pmol\/L (14 ng\/dL) at t\u2005=\u2005120 to confirm primary aldosteronism, and an area under the curve of 0.97 (95% CI [0.93, 1.00], P\u2005&amp;lt;\u20050.001). Almost half (44%) of the patients did not suppress PAC below 397 pmol\/L (14 ng\/dL) at t\u2005=\u2005120. Of them, only one (4%) patient suppressed PAC below 276 pmol\/L (10 ng\/dL) at t\u2005=\u2005240. Mean systolic blood pressure increased from 140.1\u2005\u00b1\u200521.3 mm Hg at t\u2005=\u20050 to 147.6\u2005\u00b1\u200514.5 mm Hg at t\u2005=\u2005240 (P\u2005=\u20050.011).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>A PAC of 397 pmol\/L (14 ng\/dL) at t\u2005=\u2005120 has high sensitivity and specificity for primary aldosteronism confirmation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpae017","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T07:26:11Z","timestamp":1708413971000},"page":"415-420","source":"Crossref","is-referenced-by-count":1,"title":["A 120-Minute Saline Infusion Test for the Confirmation of Primary Aldosteronism: A Pilot Study"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1637-886X","authenticated-orcid":false,"given":"Tiran","family":"Golani","sequence":"first","affiliation":[{"name":"Department of Internal Medicine D and Hypertension Unit, the Chaim Sheba Medical Center , Tel-Hashomer , Israel"},{"name":"Department of Medicine, Faculty of Medicine, Tel-Aviv University , Tel-Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Bleier","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine D and Hypertension Unit, the Chaim Sheba Medical Center , Tel-Hashomer , Israel"},{"name":"Department of Medicine, Faculty of Medicine, Tel-Aviv University , Tel-Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alon","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine D and Hypertension Unit, the Chaim Sheba Medical Center , Tel-Hashomer , Israel"},{"name":"Department of Medicine, Faculty of Medicine, Tel-Aviv University , Tel-Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammy","family":"Hod","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Tel-Aviv University , Tel-Aviv , Israel"},{"name":"Department of Medicine, Renal Transplant Center, the Chaim Sheba Medical Center , Tel-Hashomer , Israel"},{"name":"Nephrology Department, the Chaim Sheba Medical Center , Tel-Hashomer , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehonatan","family":"Sharabi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine D and Hypertension Unit, the Chaim Sheba Medical Center , Tel-Hashomer , Israel"},{"name":"Department of Medicine, Faculty of Medicine, Tel-Aviv University , Tel-Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avshalom","family":"Leibowitz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine D and Hypertension Unit, the Chaim Sheba Medical Center , Tel-Hashomer , Israel"},{"name":"Department of Medicine, Faculty of Medicine, Tel-Aviv University , Tel-Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8353-0661","authenticated-orcid":false,"given":"Ehud","family":"Grossman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Adelson School of Medicine, Ariel University , Ariel , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gadi","family":"Shlomai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine D and Hypertension Unit, the Chaim Sheba Medical Center , Tel-Hashomer , Israel"},{"name":"Department of Medicine, Faculty of Medicine, Tel-Aviv University , Tel-Aviv 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