{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T20:12:59Z","timestamp":1785787979036,"version":"3.56.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Chinese Cardiovascular Association","award":["2021-CCA-HTN-30"],"award-info":[{"award-number":["2021-CCA-HTN-30"]}]},{"name":"Natural Science Foundation of Guangdong, China","award":["2021A1515011745"],"award-info":[{"award-number":["2021A1515011745"]}]},{"name":"Natural Science Foundation of Guangdong, China","award":["2020XXG005"],"award-info":[{"award-number":["2020XXG005"]}]},{"name":"China Heart House-Chinese Cardiovascular Association","award":["2023-CCA-TCM-033"],"award-info":[{"award-number":["2023-CCA-TCM-033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Optimal antihypertensive medication for chronic type B aortic dissection (AD) remains undecided. This study compared the efficacy and safety of sacubitril\/valsartan with valsartan to determine suitable antihypertensive drug combinations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>In this single-center, open-label, randomized, controlled trial, patients with chronic Stanford type B AD and mild hypertension were randomized to receive sacubitril\/valsartan 100\/200 mg or valsartan 80\/160 mg. The primary endpoint was the reduction in mean sitting systolic blood pressure (msSBP) at week 8 in patients with sacubitril\/valsartan vs. valsartan. Key secondary endpoints included changes in (i) mean sitting diastolic blood pressure (msDBP); (ii) pulse pressure (PP); and (iii) mean ambulatory blood pressure (BP) for 24-hour, daytime, and nighttime. Safety assessments included adverse events (AEs) and serious AEs. This trial was registered with the Chinese Clinical Trial Registry, identifier: ChiCTR2300073399.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 315 patients completed the study. Sacubitril\/valsartan provided a significantly greater reduction in msSBP than valsartan at week 8 (between-treatment difference: \u22125.1 mm Hg [95% confidence interval \u22125.8 to \u22124.5], P\u2005&amp;lt;\u20050.001). Reductions in msSBP, msDBP, and PP as well as the mean ambulatory BP for 24-hour, daytime, and nighttime, were significantly greater in sacubitril\/valsartan compared with valsartan (all P\u2005&amp;lt;\u20050.001). No excessive episodes of AEs occurred in the sacubitril\/valsartan group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Sacubitril\/valsartan and valsartan reduced BP compared with baseline values. However, sacubitril\/valsartan improved BP control to a greater extent than valsartan. It may offer a new treatment option for patients with mild hypertension and chronic type B AD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpae038","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T22:59:18Z","timestamp":1712098758000},"page":"612-620","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and Safety of Sacubitril\/Valsartan in Chronic Type B Aortic Dissection Combined With Mild Hypertension"],"prefix":"10.1093","volume":"37","author":[{"given":"Xuelin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , Guangzhou, Guangdong , China"},{"name":"Shantou University Medical College , Shantou, Guangdong , 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziling","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , Guangzhou, Guangdong , China"},{"name":"School of Medicine, South China University of Technology , Guangzhou, Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University , Guangzhou, Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, 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