{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:22:34Z","timestamp":1773008554297,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T00:00:00Z","timestamp":1714780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002977","name":"Dalhousie University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000194","name":"Nova Scotia Health Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>More habitual time spent engaging in prolonged sedentary behaviors increases the risk of developing hypertension. Beat-by-beat systolic (SBPV) and diastolic blood pressure variability (DBPV) are more pronounced in persons with hypertension and may be an early manifestation of blood pressure dysregulation. We tested the hypothesis that a single bout of prolonged sitting augments very short-term SBPV and DBPV. The secondary aim was to explore sex differences in prolonged sitting-induced increases in SBPV and DBPV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Thirty-three adults (22.9\u2005\u00b1\u20051.9 years; 17 females) completed a single, 3-hour bout of prolonged sitting with beat-by-beat arterial pressure determined at baseline, 1.5-hour, and 3-hour via finger photoplethysmography.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>There were no sex differences observed for baseline brachial SBP (males: 122\u2005\u00b1\u200510 mm Hg; females: 111\u2005\u00b1\u20059 mm Hg), SBPV (males: 1.87\u2005\u00b1\u20050.63 mm Hg; females: 1.51\u2005\u00b1\u20050.38 mm Hg), DBP (males: 68\u2005\u00b1\u20056 mm Hg; females: 66\u2005\u00b1\u20058 mm Hg), or DBPV (males: 1.40\u2005\u00b1\u20050.41 mm Hg; females: 1.27\u2005\u00b1\u20050.32 mm Hg) (all, P\u2005&amp;gt;\u20050.41). In the pooled sample, baseline SBPV (1.68\u2005\u00b1\u20050.54 mm Hg) remained unchanged after 1.5 hours (1.80\u2005\u00b1\u20050.60 mm Hg; P\u2005=\u20050.59) but increased after 3.0 hours (1.84\u2005\u00b1\u20050.52 mm Hg; P\u2005=\u20050.01). This post-sitting increase was driven by males (P\u2005=\u20050.009), with no difference observed in females (P\u2005=\u20051.00). Similarly, baseline DBPV (1.33\u2005\u00b1\u20050.36 mm Hg) was similar after 1.5 hours (1.42\u2005\u00b1\u20050.41 mm Hg; P\u2005=\u20050.72) but was increased at 3 hours (1.50\u2005\u00b1\u20050.34 mm Hg; P\u2005=\u20050.02). However, no sex differences in DBPV (all, P\u2005&amp;gt;\u20050.07) were observed across the time points.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>In young, normotensive adults, a single bout of prolonged sitting augmented beat-by-beat blood pressure variability, which may provide a link between uninterrupted sitting and the development of blood pressure dysregulation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpae055","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T11:31:41Z","timestamp":1714822301000},"page":"700-707","source":"Crossref","is-referenced-by-count":4,"title":["A Single Bout of Prolonged Sitting Augments Very Short-Term Blood Pressure Variability"],"prefix":"10.1093","volume":"37","author":[{"given":"Jocelyn","family":"Waghorn","sequence":"first","affiliation":[{"name":"Division of Kinesiology, Faculty of Health, School of Health and Human Performance, Dalhousie University , Halifax, Nova Scotia , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoxuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Kinesiology, Faculty of Health, School of Health and Human Performance, Dalhousie University , Halifax, Nova Scotia , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanlin","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Kinesiology, Faculty of Health, School of Health and Human Performance, Dalhousie University , Halifax, Nova Scotia , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie E","family":"Rayner","sequence":"additional","affiliation":[{"name":"Division of Kinesiology, Faculty of Health, School of Health and Human Performance, Dalhousie University , Halifax, Nova Scotia , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek S","family":"Kimmerly","sequence":"additional","affiliation":[{"name":"Division of Kinesiology, Faculty of Health, School of Health and Human Performance, Dalhousie University , Halifax, Nova Scotia , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0665-5062","authenticated-orcid":false,"given":"Myles W","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine (Faculty of Medicine), School of Physiotherapy (Faculty of Health), Dalhousie University , Halifax, Nova Scotia , Canada"},{"name":"Department of Medicine,\u00a0Geriatric Medicine Research, Dalhousie University and Nova Scotia Health , Halifax, Nova Scotia , Canada"},{"name":"Department of Medicine, Universit\u00e9 de Sherbrooke , Sherbrooke, Quebec , Canada"},{"name":"Department of Medicine,\u00a0Centre de Formation M\u00e9dicale Du Nouveau-Brunswick, Universit\u00e9 de Sherbrooke , Moncton, New Brunswick , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,5,4]]},"reference":[{"key":"2024081405521674400_CIT0001","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4082\/kjfm.20.0165","article-title":"Sedentary lifestyle: overview of updated evidence of potential health risks","volume":"41","author":"Park","year":"2020","journal-title":"Korean J Fam Med"},{"key":"2024081405521674400_CIT0002","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12966-017-0525-8","article-title":"Sedentary Behavior Research Network (SBRN)\u2014Terminology Consensus Project process and outcome","volume":"14","author":"Tremblay","year":"2017","journal-title":"Int J Behav Nutr Phys Act"},{"key":"2024081405521674400_CIT0003","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s40279-023-01915-z","article-title":"The effect of sitting duration on peripheral blood pressure responses to prolonged sitting, with and without interruption: a systematic review and meta-analysis","volume":"54","author":"Adams","year":"2024","journal-title":"Sports Med (Auckland, N.Z.)"},{"key":"2024081405521674400_CIT0004","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/00325481.2016.1147927","article-title":"Hypertension in young adults","volume":"128","author":"De Venecia","year":"2016","journal-title":"Postgrad Med"},{"key":"2024081405521674400_CIT0005","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0091-7435(87)90087-9","article-title":"Incidence and precursors of hypertension in young adults: The Framingham offspring study","volume":"16","author":"Garrison","year":"1987","journal-title":"Prev Med"},{"key":"2024081405521674400_CIT0006","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.jacc.2007.03.009","article-title":"Early adult risk factor levels and subsequent coronary artery calcification. 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