{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:56:19Z","timestamp":1787914579007,"version":"build-2784847793"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"8","funder":[{"name":"National Institute on Disability, Independent Living, and Rehabilitation Research Model Systems","award":["90SI5017-02-00"],"award-info":[{"award-number":["90SI5017-02-00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>To compare the pharmacological treatment of hypotension and orthostatic hypotension (OH) initiated based upon a blood pressure (BP) threshold, regardless of symptoms (TXT), to usual care pharmacological treatment of symptomatic hypotension (UC), during acute inpatient rehabilitation (AIR) following spinal cord injury (SCI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Block randomization, based on the neurological level of injury as: cervical lesions (C1\u2013C8); high thoracic lesions (T1\u2013T5), and low thoracic lesions (T6\u2013T12), was used to determine responses to the primary question \u201cwas the therapy session affected by low BP or concern for low BP development?\u201d Study participants and therapists were unaware of the group assignment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 66 participants enrolled; 25 (38%) in the TXT group, 29 (44%) in the UC group, and 12 (18%) withdrew. Responses to the primary question were recorded for 32 participants, 15 in the TXT, and 17 in the UC group. There was an average of 81\u2005\u00b1\u200551 therapy sessions\/participant in the TXT and 60\u2005\u00b1\u200527 sessions\/participant in the UC group. Of those therapy sessions, low BP or concerns for low BP affected an average of 9\u2005\u00b1\u20058 sessions\/participant in the TXT group and 10\u2005\u00b1\u200512 sessions\/participant in the UC group. Neither the total number of therapy sessions (P\u2005=\u20050.16) nor group assignment (P\u2005=\u20050.83) significantly predicted the number of sessions affected by low BP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>These data are not conclusive but indicate that the treatment of asymptomatic hypotension and OH does not increase time spent in therapy compared to UC treatment of symptomatic hypotension and OH in newly injured patients with SCI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CLINICAL TRIALS REGISTRATION<\/jats:title>\n                  <jats:p>#NCT02919917.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpae057","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T09:02:51Z","timestamp":1715072571000},"page":"554-560","source":"Crossref","is-referenced-by-count":1,"title":["Treatment of Orthostatic Hypotension During Acute Inpatient Rehabilitation After Spinal Cord Injury: Usual Care vs. Anti-hypotensive Therapy"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3032-743X","authenticated-orcid":false,"given":"Jill M","family":"Wecht","sequence":"first","affiliation":[{"name":"Spinal Cord Damage Research Center, James J. Peters VA Medical Center , Bronx, New York , USA"},{"name":"the Icahn School of Medicine at Mount Sinai Department of Rehabilitation and Human Performance, , New York, New York, USA"},{"name":"Department of Medicine, the Icahn School of Medicine at Mount Sinai , New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P","family":"Weir","sequence":"additional","affiliation":[{"name":"University of Kansas Department of Health, Sport, and Exercise Sciences, , Lawrence, Kansas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Huang","sequence":"additional","affiliation":[{"name":"the Icahn School of Medicine at Mount Sinai Department of Rehabilitation and Human Performance, , New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel X","family":"Escalon","sequence":"additional","affiliation":[{"name":"the Icahn School of Medicine at Mount Sinai Department of Rehabilitation and Human Performance, , New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas N","family":"Bryce","sequence":"additional","affiliation":[{"name":"the Icahn School of Medicine at Mount Sinai Department of Rehabilitation and Human Performance, , New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,7]]},"reference":[{"key":"2024071505503672300_CIT0001","year":"2023"},{"key":"2024071505503672300_CIT0002","doi-asserted-by":"crossref","first-page":"S106","DOI":"10.1016\/j.apmr.2012.12.023","article-title":"Missed therapy time during inpatient rehabilitation for spinal cord injury","volume":"94","author":"Hammond","year":"2013","journal-title":"Arch Phys Med Rehabil"},{"key":"2024071505503672300_CIT0003","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/sj.sc.3101089","article-title":"The prevalence of orthostatic hypotension during physiotherapy 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