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But how they are involved in hypertension remains unclear. TSPYL2 may interact with JAK2\/STAT3 in PVN to sustain high blood pressure during hypertension.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Knockdown of TSPYL2 via adeno-associated virus (AAV) carrying shRNA was conducted through bilateral microinjection into the PVN of SHR and WKY rats. JAK2\/STAT3 inhibition was achieved by intraperitoneally or PVN injection of AG490 into the SHRs. Blood pressure (BP), plasma norepinephrine (NE), PVN inflammatory response, and PVN oxidative stress were measured.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>TSPYL2 knock-down in the PVN of SHRs but not WKYs led to reduced BP and plasma NE, deactivation of JAK2\/STAT3, decreased expression of pro-inflammatory cytokine IL-1\u03b2, and increased expression of anti-inflammatory cytokine IL-10 in the PVN. Meanwhile, AG490 administrated in both ways reduced the BP in the SHRs and deactivated JAK2\/STAT3 but failed to change the expression of TSPYL2 in PVN. AG490 also downregulated expression of IL-1\u03b2 and upregulated expression of IL-10. Both knockdown of TSPYL2 and inhibition of JAK2\/STAT3 can reduce the oxidative stress in the PVN of SHRs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>JAK2\/STAT3 is regulated by TSPYL2 in the PVN of SHRs, and PVN TSPYL2\/JAK2\/STAT3 is essential for maintaining high BP in hypertensive rats, making it a potential therapeutic target for hypertension.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpae067","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T01:19:35Z","timestamp":1716513575000},"page":"682-691","source":"Crossref","is-referenced-by-count":5,"title":["Testis-Specific Protein, Y-Encoded-Like 2 Activates JAK2\/STAT3 Pathway in Hypothalamic Paraventricular Nucleus to Sustain Hypertension"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9042-4768","authenticated-orcid":false,"given":"Ying","family":"Li","sequence":"first","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center , Xi\u2019an, Shaanxi , P.R. 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