{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:02:14Z","timestamp":1777618934970,"version":"3.51.4"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"State Funding for University-Level Health Research, Tampere University Hospital, Wellbeing Services County of Pirkanmaa","award":["9AC076"],"award-info":[{"award-number":["9AC076"]}]},{"name":"State Funding for University-Level Health Research, Tampere University Hospital, Wellbeing Services County of Pirkanmaa","award":["T63624"],"award-info":[{"award-number":["T63624"]}]},{"DOI":"10.13039\/501100005633","name":"Finnish Foundation for Cardiovascular Research","doi-asserted-by":"publisher","award":["SAT162"],"award-info":[{"award-number":["SAT162"]}],"id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9lius Foundation","doi-asserted-by":"publisher","award":["SAT124"],"award-info":[{"award-number":["SAT124"]}],"id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pirkanmaa Regional Fund of the Finnish Cultural Foundation","award":["MS885"],"award-info":[{"award-number":["MS885"]}]},{"name":"Finnish Kidney Foundation"},{"name":"Helsinki University Hospital","award":["TYH2022311"],"award-info":[{"award-number":["TYH2022311"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>The incidence of cardiovascular complications may be higher in unilateral than bilateral primary aldosteronism (PA). We compared noninvasive hemodynamics after targeted therapy of bilateral vs. unilateral PA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Adrenal vein sampling was performed, and hemodynamics recorded using radial artery pulse wave analysis and whole-body impedance cardiography (n\u2005=\u2005114). In 40 patients (adrenalectomy n\u2005=\u200520, spironolactone-based treatment n\u2005=\u200520), hemodynamic recordings were performed after 33 months of PA treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>In initial cross-sectional analysis, 51 patients had bilateral and 63 unilateral PA. The mean ages were 50.6 and 54.3 years (P\u2005=\u20050.081), and body mass indexes 30.3 and 30.6 kg\/m2 (P\u2005=\u20050.724), respectively. Aortic blood pressure (BP) and cardiac output did not differ between the groups, but left cardiac work was ~10% higher in unilateral PA (P\u2005=\u20050.022). In the follow-up study, initial and final BPs in the aorta were not significantly different, while initial cardiac output (+13%, P\u2005=\u20050.015) and left cardiac work (+17%, P\u2005=\u20050.009) were higher in unilateral than bilateral PA. After median treatment of 33 months, the differences in cardiac load were abolished, and extracellular water volume was reduced by 1.3 and 1.4 l in bilateral vs. unilateral PA, respectively (P\u2005=\u20050.814).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>These results suggest that unilateral PA burdens the heart more than bilateral PA, providing a possible explanation for the higher incidence of cardiac complications in unilateral disease. A similar reduction in aldosterone-induced volume excess was obtained with targeted surgical and medical treatment of PA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpae087","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T15:33:36Z","timestamp":1720625616000},"page":"884-892","source":"Crossref","is-referenced-by-count":1,"title":["Targeted Treatment Reverses Increased Left Cardiac Work in Unilateral vs. Bilateral Primary Aldosteronism"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7806-8190","authenticated-orcid":false,"given":"Eeva","family":"Kokko","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University , Tampere ,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Viukari","sequence":"additional","affiliation":[{"name":"Endocrinology, Helsinki University Hospital and Research Programs Unit, Clinical and Molecular Medicine, University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenni K","family":"Koskela","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University , Tampere ,","place":["Finland"]},{"name":"Department of Internal Medicine, Tampere University Hospital , Tampere ,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj Kumar","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University , Tampere ,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niina","family":"Matikainen","sequence":"additional","affiliation":[{"name":"Endocrinology, Helsinki University Hospital and Research Programs Unit, Clinical and Molecular Medicine, University of Helsinki , Helsinki 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