{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T11:10:23Z","timestamp":1731669023801,"version":"3.28.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>We aim to investigate the potential causal link between blood pressure (BP) levels and cerebral artery dissection (CAD) risk by employing a 2-sample Mendelian randomization (TSMR) framework.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Utilizing large-scale genome-wide association studies-retrieved data, we employed various Mendelian randomization (MR) techniques, including inverse variance weighted (IVW), MR-Egger regression, weighted median, and weighted mode, to ascertain BP\u2019s causal impact on CAD. The MR-Egger intercept was calculated to assess pleiotropy presence, determining heterogeneity by Cochran\u2019s Q statistic.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The findings highlighted a significant association between elevated systolic BP (SBP; IVW: OR\u2005=\u20053.09, 95% CI: 1.11\u20138.61, P\u2005=\u20050.031) and increased diastolic BP (DBP; IVW: OR\u2005=\u20052.17, 95% CI: 1.14\u20136.21, P\u2005=\u20050.023) with CAD risk. Sensitivity analyses reinforced the robustness and reliability of these results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The results from this TSMR study suggest a causal link between high SBP and DBP and the increased likelihood of CAD, which provides genetic evidence for a reduced risk of CAD under BP control.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpae102","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T23:00:20Z","timestamp":1722553220000},"page":"970-977","source":"Crossref","is-referenced-by-count":1,"title":["Elevated Blood Pressure: A Genetically Determined Risk Factor for Cerebral Artery Dissection"],"prefix":"10.1093","volume":"37","author":[{"given":"Xinchun","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Zhangjiagang Hospital Affiliated to Soochow University , Suzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First People\u2019s Hospital of Chenzhou , Chenzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhangjiagang Hospital Affiliated to Soochow University , Suzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhangjiagang Hospital Affiliated to Soochow University , Suzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuchu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhangjiagang Hospital Affiliated to Soochow University , Suzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Obstetrics and Gynecology Hospital of Fudan University , Shanghai ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Huadong Hospital, Fudan University , Shanghai ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoyan","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Obstetrics and Gynecology Hospital of Fudan University , Shanghai 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