{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T20:02:26Z","timestamp":1767211346024,"version":"3.37.3"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"erencia Regional de Salud de Castilla y Le\u00f3n through research projects","award":["GRS 1193\/B\/15","GRS2303\/B\/21"],"award-info":[{"award-number":["GRS 1193\/B\/15","GRS2303\/B\/21"]}]},{"name":"Instituto de Salud Carlos"},{"name":"Ministry of Science","award":["RD21\/0016\/0010","INT22\/00007"],"award-info":[{"award-number":["RD21\/0016\/0010","INT22\/00007"]}]},{"name":"Facility for Recovery and Resilience","award":["PI21\/00454"],"award-info":[{"award-number":["PI21\/00454"]}]},{"DOI":"10.13039\/501100014180","name":"Junta de Castilla y Le\u00f3n","doi-asserted-by":"publisher","award":["INT\/M\/02\/17","INT\/M\/04\/15"],"award-info":[{"award-number":["INT\/M\/02\/17","INT\/M\/04\/15"]}],"id":[{"id":"10.13039\/501100014180","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituto de Investigaci\u00f3n Biomedico de Salamanca","award":["IBI21\/00001"],"award-info":[{"award-number":["IBI21\/00001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>The progression of central blood pressure (CBP) values and central hemodynamic parameters and its relationship with cardiovascular risk factors is quite unknown. We sought to investigate this association in a Spanish adult population without cardiovascular diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Prospective observational research with a 5-year follow-up. Randomly sampled 501 individuals (mean age 56\u2005\u00b1\u200514 years, 50.3% women). After 5 years, 480 individuals had a follow-up. Measurements taken using the SphygmoCor (AtCor Medical Pty Ltd., Head Office, West Ryde, Australia), following all the recommendations established in the \u201cInternational task force\u201d (Sharman JE, Avolio AP, Baulmann J, Benetos A, Blacher J, Blizzard CL, Boutouyrie P, Chen CH, Chowienczyk P, Cockcroft JR, Cruickshank JK, Ferreira I, Ghiadoni L, Hughes A, Jankowski P, Laurent S, McDonnell BJ, McEniery C, Millasseau SC, Papaioannou TG, Vlachopoulos C. Validation of non-invasive central blood pressure devices: ARTERY Society task force consensus statement on protocol standardization. Eur Heart J 2017; 38:2805\u20132812), giving an estimate of CBP relative to measured brachial blood pressure (type 1 device).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Progressions during follow-up: central systolic blood pressure (cSBP): 4.16\u2005\u00b1\u200513.71 mm Hg; central diastolic blood pressure: 2.45\u2005\u00b1\u200511.37 mm Hg; central pulse pressure: 1.72\u2005\u00b1\u200512.43 mm Hg; pulse pressure amplification (PPA): 2.85\u2005\u00b1\u200512.20 mm Hg; ejection duration: 7.00\u2005\u00b1\u200547.87 ms; subendocardial viability ratio (SEVR): \u22128.04\u2005\u00b1\u200536.24%. In multiple regression analysis: cSBP positively associated with: body mass index (BMI) (\u03b2\u2005=\u20050.476); waist size (\u03b2\u2005=\u20050.159); number of cigarettes per day (\u03b2\u2005=\u20050.192). Inversely associated with peripheral systolic blood pressure (\u03b2\u2005=\u2005\u22120.282). Central diastolic blood pressure increase positively associated with number of cigarettes per day (\u03b2\u2005=\u20050.174). Inversely associated with peripheral diastolic blood pressure (\u03b2\u2005=\u2005\u22120.292). Central pulse pressure increase positively associated with BMI (\u03b2\u2005=\u20050.330). Inversely associated with peripheral pulse pressure (\u03b2\u2005=\u2005\u22120.262). Pulse pressure amplification increase positively associated with: BMI (\u03b2\u2005=\u20050.276); number of cigarettes per day (\u03b2\u2005=\u20050.281). Ejection duration progress inversely associated with basal plasma glucose (\u03b2\u2005=\u2005\u22120.286).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>All measures increased except for SEVR. Progressions in CBP and PPA were positively associated with anthropometric parameters and number of cigarettes and CBP inversely associated with peripheral blood pressure, although this association was different according to sex.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajh\/hpae121","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T15:59:06Z","timestamp":1726675146000},"page":"27-37","source":"Crossref","is-referenced-by-count":2,"title":["Progression in Central Blood Pressure and Hemodynamic Parameters and Relationship With Cardiovascular Risk Factors in a Spanish Population: EVA Follow-Up Study"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5964-8950","authenticated-orcid":false,"given":"David","family":"Gonz\u00e1lez-Falc\u00f3n","sequence":"first","affiliation":[{"name":"Department of Primary Care Research Unit of Salamanca (APISAL), Salamanca Primary Healthcare Management, Castilla y Le\u00f3n Regional Health Authority (SACyL), Institute of Biomedical Research of Salamanca (IBSAL) , Salamanca ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"G\u00f3mez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Primary Care Research Unit of Salamanca (APISAL), Salamanca Primary Healthcare Management, Castilla y Le\u00f3n Regional Health Authority (SACyL), Institute of Biomedical Research of Salamanca (IBSAL) , Salamanca ,","place":["Spain"]},{"name":"Department of Emergency, University Hospital de La Paz , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"G\u00f3mez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Primary Care Research Unit of Salamanca (APISAL), Salamanca Primary Healthcare Management, Castilla y Le\u00f3n Regional Health Authority (SACyL), Institute of Biomedical Research of Salamanca (IBSAL) , Salamanca ,","place":["Spain"]},{"name":"Department of Home Hospitalization, Marqu\u00e9s de Valdecilla University Hospital , Santander ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiliano","family":"Rodriguez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Primary Care Research Unit of Salamanca (APISAL), Salamanca Primary Healthcare Management, Castilla y Le\u00f3n Regional Health Authority (SACyL), Institute of Biomedical Research of Salamanca (IBSAL) , Salamanca ,","place":["Spain"]},{"name":"Department of Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS) ,","place":["Spain"]},{"name":"Department of Medicine, University of Salamanca , Salamanca ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaya","family":"Tamayo-Morales","sequence":"additional","affiliation":[{"name":"Department of Primary Care Research Unit of Salamanca (APISAL), Salamanca Primary Healthcare Management, Castilla y Le\u00f3n Regional Health Authority (SACyL), Institute of Biomedical Research of Salamanca (IBSAL) , Salamanca ,","place":["Spain"]},{"name":"Department of Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS) ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6571-9556","authenticated-orcid":false,"given":"Cristina","family":"Lugones-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Primary Care Research Unit of Salamanca (APISAL), Salamanca Primary Healthcare Management, Castilla y Le\u00f3n Regional Health Authority (SACyL), Institute of Biomedical Research of Salamanca (IBSAL) , Salamanca ,","place":["Spain"]},{"name":"Department of Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS) ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Gonzalez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Primary Care Research Unit of Salamanca (APISAL), Salamanca Primary Healthcare Management, Castilla y Le\u00f3n Regional Health Authority (SACyL), Institute of Biomedical Research of Salamanca (IBSAL) , Salamanca ,","place":["Spain"]},{"name":"Department of Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS) ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Garc\u00eda-Ortiz","sequence":"additional","affiliation":[{"name":"Department of Primary Care Research Unit of Salamanca (APISAL), Salamanca Primary Healthcare Management, Castilla y Le\u00f3n Regional Health Authority (SACyL), Institute of Biomedical Research of Salamanca (IBSAL) , Salamanca ,","place":["Spain"]},{"name":"Department of Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS) ,","place":["Spain"]},{"name":"Department of Biomedical and Diagnostic Sciences, University of Salamanca , Salamanca ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moises","family":"Diaz","sequence":"additional","affiliation":[{"name":"Institute for Technological Development and Innovation in Communications (IdeTIC), University of Las Palmas de Gran Canaria , Las Palmas de Gran Canaria ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel A","family":"G\u00f3mez-Marcos","sequence":"additional","affiliation":[{"name":"Department of Primary Care Research Unit of Salamanca (APISAL), Salamanca Primary Healthcare Management, Castilla y Le\u00f3n Regional Health Authority (SACyL), Institute of Biomedical Research of Salamanca (IBSAL) , Salamanca ,","place":["Spain"]},{"name":"Department of Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS) ,","place":["Spain"]},{"name":"Department of Medicine, University of Salamanca , Salamanca ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"EVA investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"2024121605520815100_CIT0001","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.atherosclerosis.2012.06.055","article-title":"Pulse pressure amplification, pressure waveform calibration and clinical applications","volume":"224","author":"Agnoletti","year":"2012","journal-title":"Atherosclerosis"},{"key":"2024121605520815100_CIT0002","doi-asserted-by":"crossref","first-page":"1256221","DOI":"10.3389\/fcvm.2023.1256221","article-title":"Central-to-peripheral blood pressure amplification: role of the recording site, technology, analysis approach, and calibration scheme in invasive and non-invasive data agreement","volume":"10","author":"Z\u00f3calo","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"2024121605520815100_CIT0003","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1093\/eurheartj\/ehw632","article-title":"Validation of non-invasive central blood pressure devices: ARTERY Society task force consensus statement on protocol standardization","volume":"38","author":"Sharman","year":"2017","journal-title":"Eur Heart J"},{"key":"2024121605520815100_CIT0004","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1097\/HJH.0000000000003480","article-title":"2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension: endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA)","volume":"41","author":"Mancia","year":"2023","journal-title":"J Hypertens"},{"key":"2024121605520815100_CIT0005","first-page":"234","article-title":"2019 Consensus of the Taiwan Hypertension Society and Taiwan Society of Cardiology on the clinical application of central blood pressure in the management of hypertension","volume":"35","author":"Cheng","year":"2019","journal-title":"Acta Cardiol Sin"},{"key":"2024121605520815100_CIT0006","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/jch.14853","article-title":"Association of cardiovascular events with central systolic blood pressure: a systemic review and meta-analysis","volume":"26","author":"Li","year":"2024","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"2024121605520815100_CIT0007","doi-asserted-by":"crossref","first-page":"906021","DOI":"10.3389\/fcvm.2022.906021","article-title":"Clinical implications of central blood pressure measured by radial tonometry and automated office blood pressure measured using automatic devices in cardiovascular diseases","volume":"9","author":"Kwon","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"2024121605520815100_CIT0008","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/s41440-020-0493-2","article-title":"Central blood pressure predicts the development of hypertension in the general population","volume":"43","author":"Sugiura","year":"2020","journal-title":"Hypertens Res"},{"key":"2024121605520815100_CIT0009","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1161\/HYPERTENSIONAHA.119.13478","article-title":"Association between central blood pressure and subclinical cerebrovascular disease in older adults","volume":"75","author":"Matsumoto","year":"2020","journal-title":"Hypertension"},{"key":"2024121605520815100_CIT0010","doi-asserted-by":"crossref","first-page":"e026603","DOI":"10.1161\/JAHA.122.026603","article-title":"Prediction of cardiovascular events by pulse waveform parameters: analysis of CARTaGENE","volume":"11","author":"Desbiens","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"2024121605520815100_CIT0011","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1093\/eurheartj\/ehu293","article-title":"Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors","volume":"35","author":"Herbert","year":"2014","journal-title":"Eur Heart J"},{"key":"2024121605520815100_CIT0012","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/s41440-020-0490-5","article-title":"Reference values of office central blood pressure, pulse wave velocity, and augmentation index recorded by means of the Mobil-O-Graph PWA monitor","volume":"43","author":"Paiva","year":"2020","journal-title":"Hypertens Res"},{"key":"2024121605520815100_CIT0013","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1097\/HJH.0000000000002178","article-title":"Cross-sectional analysis of pulsatile hemodynamics across the adult life span: reference values, healthy and early vascular aging: the Heinz Nixdorf Recall and the MultiGeneration Study","volume":"37","author":"Weber","year":"2019","journal-title":"J Hypertens"},{"key":"2024121605520815100_CIT0014","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1097\/HJH.0000000000002916","article-title":"Reference values of central blood pressure and central haemodynamic parameters and their relationship with cardiovascular risk factors in a Spanish population: early vascular ageing study","volume":"39","author":"G\u00f3mez-S\u00e1nchez","year":"2021","journal-title":"J Hypertens"},{"key":"2024121605520815100_CIT0015","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1161\/HYPERTENSIONAHA.121.17765","article-title":"Twenty-Four-Hour Central (Aortic) systolic blood pressure: reference values and dipping patterns in untreated individuals","volume":"79","author":"Weber","year":"2022","journal-title":"Hypertension"},{"key":"2024121605520815100_CIT0016","doi-asserted-by":"crossref","first-page":"e011031","DOI":"10.1136\/bmjopen-2016-011031","article-title":"Association between different risk factors and vascular accelerated ageing (EVA study): study protocol for a cross-sectional, descriptive observational study","volume":"6","author":"Gomez-Marcos","year":"2016","journal-title":"BMJ Open"},{"key":"2024121605520815100_CIT0017","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1161\/01.CIR.95.7.1827","article-title":"Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure. Validation of generalized transfer function","volume":"95","author":"Chen","year":"1997","journal-title":"Circulation"},{"key":"2024121605520815100_CIT0018","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1097\/HJH.0000000000001961","article-title":"2018 Practice Guidelines for the management of arterial hypertension of the European Society of Hypertension and the European Society of Cardiology: ESH\/ESC Task Force for the Management of Arterial Hypertension","volume":"36","author":"Williams","year":"2018","journal-title":"J Hypertens"},{"key":"2024121605520815100_CIT0019","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/sim.7956","article-title":"Combining multiple imputation and bootstrap in the analysis of cost-effectiveness trial data","volume":"38","author":"Brand","year":"2019","journal-title":"Stat Med"},{"key":"2024121605520815100_CIT0020","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1161\/HYPERTENSIONAHA.118.11642","article-title":"Different effects of vascular aging on ischemic predisposition in healthy men and women","volume":"72","author":"Namasivayam","year":"2018","journal-title":"Hypertension"},{"key":"2024121605520815100_CIT0021","doi-asserted-by":"crossref","first-page":"e2215513","DOI":"10.1001\/jamanetworkopen.2022.15513","article-title":"Accuracy difference of noninvasive blood pressure measurements by sex and height","volume":"5","author":"Abbaoui","year":"2022","journal-title":"JAMA Netw Open"},{"key":"2024121605520815100_CIT0022","doi-asserted-by":"crossref","first-page":"e0170218","DOI":"10.1371\/journal.pone.0170218","article-title":"Assessing sex differences in the risk of cardiovascular disease and mortality per increment in systolic blood pressure: a systematic review and meta-analysis of follow-up studies in the United States","volume":"12","author":"Wei","year":"2017","journal-title":"PLoS One"},{"key":"2024121605520815100_CIT0023","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1097\/HJH.0b013e328344da5e","article-title":"Gender differences in artery wall biomechanical properties throughout life","volume":"29","author":"Rossi","year":"2011","journal-title":"J Hypertens"},{"key":"2024121605520815100_CIT0024","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41440-018-0161-y","article-title":"Determinants of pulse pressure amplification in hypertensive and diabetic patients","volume":"42","author":"Vall\u00e9e","year":"2019","journal-title":"Hypertens Res"},{"key":"2024121605520815100_CIT0025","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1093\/eurheartj\/ehq024","article-title":"Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis","volume":"31","author":"Vlachopoulos","year":"2010","journal-title":"Eur Heart J"},{"key":"2024121605520815100_CIT0026","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1097\/HJH.0000000000000898","article-title":"Hemodynamic parameters in hypertensive diabetic patients","volume":"34","author":"Yannoutsos","year":"2016","journal-title":"J Hypertens"},{"key":"2024121605520815100_CIT0027","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1161\/HYPERTENSIONAHA.121.18773","article-title":"Risk stratification by cross-classification of central and brachial systolic blood pressure","volume":"79","author":"Cheng","year":"2022","journal-title":"Hypertension"}],"container-title":["American Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajh\/advance-article-pdf\/doi\/10.1093\/ajh\/hpae121\/59892231\/hpae121.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/38\/1\/27\/60828065\/hpae121.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajh\/article-pdf\/38\/1\/27\/60828065\/hpae121.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T05:52:29Z","timestamp":1734328349000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajh\/article\/38\/1\/27\/7760188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,18]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,9,18]]},"published-print":{"date-parts":[[2024,12,16]]}},"URL":"https:\/\/doi.org\/10.1093\/ajh\/hpae121","relation":{},"ISSN":["0895-7061","1941-7225"],"issn-type":[{"type":"print","value":"0895-7061"},{"type":"electronic","value":"1941-7225"}],"subject":[],"published-other":{"date-parts":[[2025,1]]},"published":{"date-parts":[[2024,9,18]]}}}